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Mark Basik

Mark Basik

Assistant Professor, Departments of Surgery and Oncology, McGill University

Lady Davis Institute for Medical Research
Sir Mortimer B. Davis-Jewish General Hospital
3755 Cote-Ste-Catherine Road
Montreal, Quebec H3T 1E2

Tel.: 514-340-8222 ext. 8248
Fax: 514-340-8716
mark [dot] basik [at] mcgill [dot] ca (Email)
Dr. Basik's Website

Expertise: Genomics Of Breast And Colon Cancer

Summary of Research Activities
The laboratory’s area of interest is investigating gene expression and DNA changes in breast and colon cancer. Using modern microarray technology, we are investigating the relationship between changes in DNA copy number and gene expression across the genome, in both cell lines and primary tumors. The goal is to find genes that are both overexpressed and amplified in these cancers. These genes will then be candidate targets for novel anti-cancer therapies. They will be functionally validated using small interfering RNA approaches, and clinically validated using tissue microarrays constructed in our laboratory. We are also involved in the discovery of new diagnostic markers in breast and colon cancer, with a special focus on markers of breast cancer metastasis, specifically chemokines and their receptors. We are also investigating mechanisms of resistance to novel biologics such as herceptin, new blood-based breast tumor markers using proteomics technology and stromal-epithelial interactions in breast tumor biology. Finally, we are part of the FRSQ Réseau de la recherche sur le cancer, axe banque de tissus et de données, and as such are actively participating in a province-wide breast tumor banking as well as primary breast tumor culture.

Recent Publications
Aguilar-Mahecha A, Hassan S, Ferrario C, Basik M. Microarrays as validation strategies in clinical samples: tissue and protein microarrays. OMICS. 2006 Fall;10(3):311-26. Review