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Natalie Grizenko, MD, FRCPC

Natalie Grizenko, MD, FRCPC

Dr. Grizenko is Associate Professor of Psychiatry at McGill, Medical Chief of the Division of Child and Adolescent Psychiatry at the Douglas Hospital, and Director of the Lyall Disruptive Behaviour Disorders Program. She received her medical training at the University of Sherbrooke and at McGill University. Dr. Grizenko's research interests are:

  • ADHD
  • risk and protective factors for psychiatric disorders in children and immigrants
  • evaluation research of child day treatment programs

She can supervise trainees and graduate students from psychiatry, psychology, anthropology, and social services.

natalie [dot] grizenko [at] douglas [dot] mcgill [dot] ca (email) website


Selected Articles

Hébert, J., Polotskaia, A., Joober, R., Grizenko, N., (2013) Adherence to psychostimulant medication in children with ADHD : The role of attitudes. Canadian Journal of Child and Adolescent Psychiatry, 22(4):203-309.

Choudhry, Z., Sengupta, S.M., Grizenko, N., Thakur, G.A., Fortier, M.-E., Schmitz, N., Joober, R. (2013) Association between obesity-related gene FTO and ADHD. Obesity, March 20, doi:10-1002/oby.20444.

Grizenko, N., Pereira, R.M., Joober, R., (2013) Sensitivity of scales to evaluate change in symptomatology with psychostimulants in different ADHD subtypes. Canadian Journal of Child and Adolescent Psychiatry, 22(2):153-158.

Choudry, Z., Sengupta, S.M., Grizenko, N., Harvey, W.J., Fortier M.-E., Schmitz, N., Joober, R., (2013) Body Weight and ADHD: examining the role of self-regulation PLOS ONE, 8(1):e 55351.doi 10.1371/journal.pone.0055351 epub: Jan. 29.

Thakur, G., Sengupta, S., Grizenko, N., Schmitz, N., Page, V., Joober, R. (2013) Maternal smoking during pregnancy and ADHD: a comprehensive clinical and neurocognitive characterization. Nicotine and tobacco research, Jan. 15(1) 149-57, doi:10.1093/ntr/nts102, Epub 2012, Apr. 22. 

Harvey, W.J., Wilkinson, S., Pressé, C., Joober, R., Grizenko, N., (2012) Children say the darndest things: Physical activity and children with ADHD. Physical Education and Sport Pedagogy, doi.org/10.1080/17408989.2012.75400.

Wilkinson, S., Harvey, W.J., Bloom, G.A., Joober, R. & Grizenko, N., (2012) Student Teacher Experience Physical education in a service-learning project for children with Attention-Deficit Hyperactivity Disorder. Physical Education and Sports Pedagogy, DOI:10 1080/17408989.2012, 690385.


Harvey, W.J., Wilkinson, S., Pressé, C., Joober, R., Grizenko, N., (2012) Scrapbook interviewing and children with ADHD. Qualitative Research in Sport, Exercise and Health, 4(1): 62‑79.


Thakur, G., Sengupta, S.M., Grizenko, N., Choudry, Z., Joober, R., (2012) Comprehensive phenotype/genotype analysis of norepinephrine transporter gene (SL6A2) in ADHD: relationship to maternal smoking during pregnancy PLOS ONE:7(11):e49616, doi:10.1371/journal. pone.0049616. Epub, Nov. 20.

Grizenko, N., Zhang, D.D.Q., Polotskaia, A., Joober, R., (2012) Efficacy of methylphenidate in ADHD children within the normal and gifted intellectual spectrum. J Can Academy of Child and Adolescent Psychiatry, 21(4):282-288.

Thakur, G.A. Sengupta, S.M., Grizenko, N. Choudry, Z., Joober, R. (2012) Family-based association study of ADHD and genes increasing the risk for smoking behavior Arch Dis Child. Dec.:97(12):1027-33, doi:10.1136/archdischild2012-301882, Epub, Oct, 29.


Fortier, M.-E., Sengupta, S.M., Grizenko, N., Bellingham, J., Choudhry, Z., Joober, R. (2012) Genetic evidence for the association of the hypothalamic-pituatary-adrenal (HPA) axis with ADHD and methylphenidate treatment response Neuromolecular Medicine, Oct 10, doi:10.1007/s12017-012-8202-1.

Choudry, Z., Sengupta, S.M., Grizenko, N., Fortier, M.-E., Thakur, G., Bellingham, J., Joober, R., (2012) Association between LPHN3 and ADHD disorder: interaction with maternal stress during pregnancy. J Child Psychol Psychiatry, Aug 53(8):892-902 doi:10.1111/j1469-7610.2012.02551x, Epub, Apr. 7.

Choudry, Z., Sengupta, S., Thakur, G., Page, V., Schmitz, N., Grizenko, N., Joober, R. (2012) Catechol-o-methyltransferane (COMT) gene and executive function in children with ADHD. Journal of Attention Disorders, March 26, DOI:101177/10870547123815.

Grizenko, N., Fortier, M-E., Zadorozny, C., Thakur, G.A., Schmitz, N., Duval, R., Joober, R., (2012) Maternal stress during pregnancy, ADHD symptomatology in children and genotype: gene-environment interaction. J Can Academy.of Child and Adolescent Psychiatry 21(1):9-15. (Featured article).


Sengupta, S.M., Grizenko, N., Thakur, G.A., Bellingham, J., De Guzman, R., Robinson, S., Ter-Stepanian, M., Polotskaia, A., Shaheen, S.M., Fortier, M-E., Choudry, Z., Joober, R., (2012) Differential association between the norepinephrine transporter gene and ADHD-role of gender and subtype. J. Psychiatry Neurosciences, 37(2):129-137. 

Hantson, J., Wang, P.P., Grizenko-Vida, M., Ter-Stepanian, M., Harvey, W.J., Joober, R. & Grizenko, N. (2012) Effectiveness of a therapeutic summer camp for children with Attention-Deficit/Hyperactivity Disorder: Phase 1 Clinical Intervention Trial. Journal of Attention Disorders, 16(7): 610-617.

Lee, J., Grizenko, N., Bhat, V., Sengupta, S., Polotskaia, A., & Joober, R. (2011). Relationship between therapeutic response and side effects induced by methyphenidate as observed by parents and teachers of children with ADHD. BMC Psychiatry, 11, 70.

Grizenko, N., Paci, M., & Joober, R. (2010). Is the inattentive subtype of ADHD different from the combined/hyperactive subtype? Journal of Attention Disorders, 13(6), 649-657.

Ter-Stepanian, M., Grizenko, N., Zappitelli, M., & Joober, R. (2010). Clinical response to methylphenidate in children diagnosed with ADHD and comorbid psychiatric disorders. The Canadian Journal of Psychiatry 55(5), 127-134. 

Thakur, G., Grizenko, N., Sengupta, SM., Schmitz, N., & Joober, R. (2010). The 5-HTTLPR polymorphism of the serotonin transporter gene and short term behavioural response to methlphenidate in children with ADHD. BMC Psychiatry, 10, 55.

Karama, S., Ben Amor, L., Grizenko, N., Ciampi, A., Mbekou, V., Ter Stepanian, M., Lageix, P., Baron, C., Schwartz, G., & Joober, R. (2009). Factor structure of the Restricted Academic Situation Scale, implications for ADHD. Journal of Attention Disorders, 12(5), 442-448.

Harvey, W. J., Reid, G., Bloom, G. A., Staples, K., Grizenko, N., Mbekou, V., Ter Stepanian, M., & Joober, R. (2009). Physical activity experiences of boys with and without ADHD. Adapted Physical Activity Quaterly, 26, 131-150.

Gruber, R., Joober, R., Grizenko, N., Leventha, BL., Cook, EH., & Stein, MA (2009). Dopamine transporter genotype and stimulant side effect factors in ADHD youth. Journal of Child and Adolescent Psychopharmacology 19(3), 233-239.

Kebir, O., Grizenko, N., Sengupta, S., & Joober, R. (2009). Verbal but not performance IQ is highly correlated to externalizing behaviour in boys with ADHD carrying both DRD 4 and DAT 1 risk genotypes. Progress in Neuropsychopharmcology & Biological Psychiatry, 33(6), 939-944.

Grizenko, N., Rajabien Shayan, Y., Polotskaia, A., Ter-Stepanian, M., & Joober, R. (2008). Maternal Stress during pregnancy and how it relates to symptom severity and response to treatment in children with ADHD. Journal of Psychiatry and Neuroscience, 33(1), 10-16.

Karama, S., Grizenko, N., Sonuga-Barke, E., Doyle, A., Biederman J.,Mbekou, V., Polotskaia, A., Ter-Stepanian, M., De Guzman, R., Bellingham, J., Sengupta, S., & Joober, R. (2008). Dopamine transporter 3’UTR VNTR genotype is a marker of performance on executive function tasks in children with ADHD. BMC Psychiatry, 8, 45.

Sengupta, S., Grizenko, N., Schmitz, N., Schwartz, G., Bellingham, J., Polotskaia, A., Ter Stepanian, M., De Guzman, R., Goto, Y., Grace, A., & Joober, R. (2008). COMT Val 108/158 met polymorphism modulates task-oriented behaviour in children with ADHD. Neuropsychopharmacology, 33(13), 3069-77.

Bhat, V., Grizenko, N., Sanche, S., & Joober, R. (2008). No relationship between therapeutic response to methylphenidate and its cardiovascular side effects in children with ADHD. Clinical Medicine Insights: Pediatrics, 1, 37-42.

Joober, R., Grizenko, N., Sengupta, S., Ben Amor, L., Schmitz, N., Schwartz, G., Karama, S., Lageix, P., Fathalli, F., Torkamen-Zehi, A., & Ter-Stepanian, M. (2007). Dopamine transporter 3 – UTR VNTR genotype and ADHD: A pharmaco-behavioral genetic study with methylphenidate. Neuropsychopharmacology, 32, 1370-1376.

Grizenko, N., & Joober, R. (2007). Understanding the pharmacogenetics of ADHD. The ADHD Report, 15(1), 10-16.

Gruber, R., Grizenko, N., & Joober, R. (2007). Delayed Phase Sleep Syndrome, ADHD and Bright Light Therapy. Journal of Clinical Psychiatry 68(2), 337-338.

Gruber, R., Grizenko, N., Schwartz, G. Bellingham, J., Guzman, RM., & Joober, R. (2007). Performance on the continuous performance test in children with ADHD is associated with sleep efficiency. Sleep, 30(8), 1003-1009.

Harvey, W. J., Reid, G., Grizenko, N., Mbekou, V., Ter-Stepanian, M., & Joober, R. (2007). Fundamental movement skills and children with ADHD: Peer comparisons and stimulant effects. Journal of Abnormal Child Psychology, 35, 871-882

Grizenko, N., Ter-Stepanian, M., & Joober, R. (2007). Attention Deficit/Hyperactivity Disorder and learning disabilities: Pathophysiology and treatment. Advances in ADHD, 2, 42-47

Gruber, R., Grizenko, N., Schwartz, G., Ben Amor L., Gauthier, J., de Guzman, R., & Joober, R. (2006). Sleep and COMT polymorphism in ADHD: Preliminary actigraphic data. Journal of the American Academy of Child and Adolescent Psychiatry, 45(8), 982-990.

Sengupta, SM., Grizenko, N., Schmitz, N., Schwartz, G., Ben Amor, L., Bellingham, J., De Guzman, R., Polotskaia, A., Ter Stepanian, M., Thakur, G., & Joober, R. (2006). Comt Val 108/158 Met gene variant, birthweight and conduct disorder in children with ADHD. Journal of the American Academy of Child and Adolescent Psychiatry, 45(11), 363-1369.

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