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Nancy Frasure-Smith, PhD

Nancy Frasure-Smith is Emeritus Professor of Psychiatry at McGill; Senior Research Associate at the Montreal Heart Institute; Professeure Associée, Département de psychiatrie, Université de Montréal; and associated Researcher at the Centre de Recherche du Centre hospitalier de l’Université de Montréal (CRCHUM). She completed her PhD in sociology at the Johns Hopkins University and postdoctoral training in psychology at McGill. She first came to the Division of Social and Transcultural Psychiatry in the early 1980’s as a researcher working with the late Dr Raymond Prince on the Ischemic Heart Disease Life Stress Monitoring Study. Since then, her research program, carried out in conjunction with psychiatrists, cardiologists and nurses at McGill, the Université de Montréal and the Montreal Heart Institute, has focused on:

  1. assessing the importance of psychological and social variables in the development and prognosis of cardiovascular disease;
  2. exploring physiological and behavioural mechanisms linking psychological and social variables with cardiovascular disease;
  3. developing and evaluating interventions to change the impact of psychological and social variables in cardiovascular disease.

nancy [dot] frasure-smith [at] mcgill [dot] ca (email)


Selected Articles

Cossette, S., Frasure-Smith, N., Vadeboncoeur, A., McCusker, J., & Guertin, M. C. The impact of an emergency department nursing intervention on continuity of care, self-care capacities and psychological symptoms: Secondary outcomes of a randomized controlled trial. International Journal of Nursing Studies 2015 52 (3): 666-676.

Malan, L., Hamer, M., Frasure-Smith, N., Steyn, H. S., & Malan, N.T. Cohort Profile: Sympathetic activity and Ambulatory Blood Pressure in Africans (SABPA) prospective cohort study. Intenational Journal of Epidemiology (published on line October 14, 2014).

Licthman, J., Froelicher, E. S., Blumenthal, J. A., Carney, R. M., Doering. L. V., Frasure-Smith, N., Freedland, K. E., Jaffe, A. S., Leifheit-Limson. E. C., Sheps, D. S., Vaccarino, V., & Wulsin, L. Depression as a risk factor for poor prognosis among patients with acute coronary syndrome: Systematic review and recommendations ( A scientific statement from the American Heart Association). Circulation March 25, 2014 129 (12):1350-69. 

Suman-Horduna, I., Roy, D., Frasure-Smith, N., Talajic, M., Lesppérance, F., Blondeau, L., Dorian, P., & Khairy, P; AF-CHF Trial Investigators. Quality of life and functional capacity in patients with atrial fibrillation and congestive heart failure. Journal of the American College of Cardiology 2013 61(4):455-60.

Thibault, B., Harel, F., Ducharme, A., White, M., Ellenbogen, K., Frasure-Smith, N., Roy, D., Phillipon, F., Dorian, P., Talajic, M., Dubuc, M., Guerra, P., Macle, L., Rivard, L., Andrade, J., Khairy, P., & EARTH Investigators. Cardiac Resynchronization Therapy in Patients with Heart Failure and a QRS Complex <120 ms: the LESSER-EARTH Trial. Circulation 2013 127 (8):873-881.

Malan, L., Hamer, M., Schlaich, M. P., Lambert, G., Ziemssen, T., Reimann, M., Frasure-Smith, N., Amirkhan, J. H., Schutte, R., van Rooyen, J. M., Mels, C. M., Fourie, C. M., Uys, A. S., & Malan, N.T. Defensive coping facilitates higher blood pressure and early sub-clinical structural vascular disease via alterations in heart rate variability: The SABPA study. Atherosclerosis 2013 227(2): 391-397. 

Keeping-Burke, L., Purden, M., Frasure-Smith, N., Cossette, S., McCarthy, F., & Amsel, R. Bridging the transition from hospital to home: Effects of the VITAL telehealth program on recovery for CABG surgery patients and their caregivers. Research in Nursing and Health 2013; 36:540–553.

Davidson, K. W., Bigger, J. T., Burg, M. M., Carney, R. M., Chaplin, W. F., Czajkowski, S., Dornelas, E., Duer-Hefele, J., Frasure-Smith, N., Freedland, K. E., Haas, D. C., Jaffe, A. S., Ladapo, J. A., Lespérance, F., Medina, V., Newman, J. D., Osorio, G. A., Parsons, F., Schwartz, J. E., Shaffer, J. A., Shapiro, P. A., Sheps, D. S., Vaccarino, V., Whang, W., & Ye, S. Centralized, stepped, patient preference-based treatment for patients with post-acute coronary syndrome depression: CODIACS vanguard randomized controlled trial. JAMA Internal Medicine 2013 173 (11):997-1004.

Cossette, S., Vadeboncoeur, A., Frasure-Smith, N., McCusker, J., Perreault, D., & Guertin, M. C. Randomized controlled trial of a nursing intervention to reduce emergency department revisits. Canadian Journal of Emergency Medicine 2013 15(0):1-8. 

Cossette, S., Frasure-Smith, N., Robert, M., Chouinard, M-C., Juneau, M., Guertin, M-C., Cournoyer, A., Mailhot, T., & Kayser, J. W. A pilot randomized trial of a smoking cessation nursing intervention in cardiac patients after hospital discharge. Canadian Journal of Cardiovascular Nursing 2012 Fall; 22(4):16-26. (published February 2013)

Thibault, B., Harel, F., Ducharme, A., White, M., Ellenbogen, K., Frasure-Smith, N., Roy, D., Phillipon, F., Dorian, P., Talajic, M., Dubuc, M., Guerra, P., Macle, L., Rivard, L., Andrade, J., Khairy, P.; LESSER EARTH Investigatots. Cardiac Resynchronization Therapy in Patients with Heart Failure and a QRS Complex <120 ms: the LESSER-EARTH Trial. Circulation (published on line February 6, 2013).

Malan, L., Hamer, M., Schlaich, M. P., Lambert, G., Ziemssen, T., Reimann, M., Frasure-Smith, N., Amirkhan, J. H., Schutte, R., van Rooyen, J. M., Mels, C. M., Fourie, C. M., Uys, A. S., & Malan, N. T. Defensive coping facilitates higher blood pressure and early sub-clinical structural vascular disease via alterations in heart rate variability: The SABPA study. Atherosclerosis (published on line January 17, 2013).

Suman-Horduna, I., Roy, D., Frasure-Smith, N., Talajic, M., Lesppérance, F., Blondeau, L., Dorian, P., Khairy, P; AF-CHF Trial Investigators. Quality of life and functional capacity in patients with atrial fibrillation and congestive heart failure. Journal of the American College of Cardiology published online ahead of print December 13, 2012.

Hamer, M., Frasure-Smith, N., Lespérance, F., Harvey, B. H., Malan, N. T., & Nalan, L. Depressive symptoms and 24-hour ambulatory blood pressure in Africans: The SABPA Study.  Int J Hypertens. 2012;2012:426803. [Epub 2011 Oct 19].

Whang, W., Burg, M. M., Carney, R. M., Freedland, K. E., Bigger, J. T., Catellier, D., Czajkowski, S., Frasure-Smith, N., Haas, D. C., Jaffe, A. S., Lespérance, F., Medina, V., Duer-Hefele, J., Osorio, G. A., Parsons, F., Shapiro, P. A., Sheps, D. S., Vaccarino, V., & Davidson, K. W. Design and baseline data from the vanguard of the Comparison of Depression Interventions after Acute Coronary Syndrome (CODIACS) randomized controlled trial. Contemporary Clinical Trials 2012 Sep;33(5):1003-10 published online ahead of print May 25, 2012.

Frasure-Smith, N., Lespérance, F., Talajic, M., Khairy, P., Dorian, P., O’Meara, E., & Roy, D. Anxiety sensitivity moderates prognostic importance of rhythm- versus rate-control strategies in patients with atrial fibrillation and congestive heart failure: Insights from the AF-CHF Trial. Circulation Heart Failure 2012, 5:322-330  published online ahead of print March 22,2012.

Cossette, S., Frasure-Smith, N., Dupuis, J., Juneau, M., Guertin, M-C. Randomized controlled trial of tailored nursing interventions to improve cardiac rehabilitation enrolment. Nursing Research, 2012 published online January 26, 2012.

Cossette, S., Frasure-Smith, N., Robert, M., Chouinard, M-C, Juneau, M., Guertin, M-C., Cournoyer, A., & Mailhot, T. Évaluation préliminaire d'une intervention infirmière de soutien à la cessation tabagique chez des patients hospitalisés pour un problème cardiaque : étude pilote (So-Live). Recherche en soins infirmiers, 105 (juin) 60-75, 2011.

Thibault, B., Harel, F., Ducharme, A., White, M., O’Meara, E., Guertin, M-C., Lavoie, J., Frasure-Smith, N., Dubuc, M., Guerra, P., Macle, L., Rivard, L., Roy, D., Talajic, M., Dubuc, M., Khairy, P.; Evaluation of Resynchronization Therapy for Heart Failure (GREATER-EARTH) Investiators. Left ventricular versus simultaneous biventricular pacing in patients with heart failure and a QRS complex ³120 milliseconds. Circulation 2011; 124, 25:2874-; published online November 21, 2011.

Houle, J., Beaulieu, M. D., Lespérance, F., Frasure-Smith, N., & Lambert, J. (2010). Inequities in medical follow-up for depression: A population-based study in Montreal. Psychiatric Services 61, 258-263.

Paradis, V., Cossette, S., Frasure-Smith, N., Heppell, S., & Guertin, M-C. (2010). The efficacy of a motivational nursing intervention based on the stages of change on self-care in heart failure patients. Journal of Cardiovascular Nursing, 25(2), 130-141. 

Lespérance, F., Frasure-Smith, N., St-André, E., Turecki, G., Lespérance, P., & Wisniewski, S. R. (2010). The efficacy of omega-3 supplementation for major depression: a randomized controlled trial. Journal of Clinical Psychiatry.

Habra, M. E., Baker, B., Frasure-Smith, N., Swenson, J. R., Koszycki, D., Butler, G., van Zyl, L. T., & Lespérance, F. (2010). First episode of major depressive disorder and vascular factors in coronary artery disease patients: Baseline characteristics and response to antidepressant treatment in the CREATE trial. Journal of Psychosomatic Research, 69(2) 133-41.

Frasure-Smith, N., & Lespérance, F. (2010). Depression and cardiac risk: Present status and future directions. [Editorial]. Heart, 96, 173-176. Reprinted in Postgraduate Medical Journal, 86, 193-196, 2010.  

vanZyl, L., Lespérance, F., Frasure-Smith, N., Malinin, A. I., Atar, D., LaLiberté, M. A., & Serebruany, V. L. (2009). Platelet and endothelial activity in comorbid major depression and coronary artery disease patients treated with citalopram: The Canadian Cardiac Randomized Evaluation of Antidepressant and Psychotherapy Efficacy Trial (CREATE) Biomarker Sub-study. Journal of Thrombsois and Thrombolysis 27(1), 48-56.

McCaffery, J., Duan, Q. L., Frasure-Smith, N., Barhdadi, A., Lespérance, F., Théroux, P., Rouleau, G. A., & Dubé, M. P. (2009). Genetic predictors of depressive symptoms in cardiac patients. American Journal of Medical Genetics Part B (Neuropsychiatric Genetics), 150B(3), 381-8.

Frasure-Smith, N., Lespérance, F., Habra, M., Talajic, M., Khairy, P., Dorian, P., & Roy, D. (2009). For the Atrial Fibrillation and Congestive Heart Failure Investigators. Elevated depression symptoms predict long-term cardiovascular mortality in patients with atrial fibrillation and heart failure. Circulation, 120, 134-140.

Frasure-Smith, N., Lespérance, F., Irwin, M. R., Talajic, M., & Pollock, B. G. (2009). The relationships among heart rate variability, inflammatory markers and depression in coronary heart disease patients. Brain, Behavior and Immunity, 23, 1140-1147.

Cossette, S., D’Aoust, L. X., Morin, M., & Frasure-Smith, N. (2009). The systematic development of a nursing intervention aimed at increasing enrolment in cardiac rehabilitation for acute coronary syndrome patients. Progress in Cardiovascular Nursing, 24, 71-79.

Nigam, A., Frasure-Smith, N., Lespérance, F., & Juliene, P. (2009). Relationship between n-3 and n-6 plasma fatty acid levels and insulin resistance in coronary patients with and without metabolic syndrome. Nutrition, Metabolism & Cardiovascular Diseases, 19(4), 264-270.

Thombs, B., de Jonge, P., Coyne, J. C., Whooley, M. A., Frasure-Smith, N., Mitchell, A. J., Zuidersma, M., Eze-Nliam, C., Lima, B. B., Smith, C. G., Sodurlund, K., & Ziegelstein, R. (2008). Depression screening and patient outcomes in cardiovascular care: A systematic review. JAMA, 300(18), 2161-2171.

Lichtman, J. H., Bigger, J. T., Blumenthal, J. A., Frasure-Smith, N., Kaufmann, P. G., Lespérance, F., Mark, D. B., Sheps, D. S., Taylor, C. B., & Froelicher, E. S. (2008). Depression and coronary heart disease. Recommendations for screening, referral, and treatment. A science advisory from the American Heart Association Prevention Committee of the Council on Cardiovascular Nursing, Council on Clinical Cardiology, Council on Epidemiology and Prevention, and Interdisciplinary Council on Quality of Care and Outcomes Research. Circulation 118(17), 1768-75.

Frasure-Smith, N., & Lespérance F. (2008). Depression and anxiety as predictors of two-year cardiac events in patients with stable coronary artery disease. Archives of General Psychiatry, 65(1), 62-71.

Frasure-Smith, N., Lespérance, F., Irwin, M. R., Sauvé, C., Lespérance, J., & Théroux, P. (2007). Depression, C-reactive protein and two-year major adverse cardiac events in men after acute coronary syndromes. Biological Psychiatry, 62, 302-308.

Lespérance, F., Frasure-Smith, N., Koszycki, D., Laliberté, M. A., van Zyl, L. T., Baker, B., Swenson, J. R., Ghatavi, K., Abramson, B.L., Dorion, P., & Guertin, M. C. (2007). Effects of citalopram and interpersonal psychotherapy on depression in coronary artery disease patients: The Canadian Cardiac Randomized Evaluation of Antidepressant and Psychotherapy Efficacy Trial (CREATE). JAMA, 297(4), 367-379.

Duan, Q. L., Dubé, M. P., Frasure-Smith, N., Barhdadi, A., Lespérance, F., Théroux, P., St-Onge, J., Rouleau, G. A., & McCaffery, J. M. (2007). Additive effects of obesity and TCF7L2 variants on risk for type 2 diabetes among cardiac patients.  Diabetes Care, 30, 1621-1623.

Atar, D., Malanin, A., Pokov, A., van Zyl, L., Frasure-Smith, N., Lespérance, F., & Serebruany, V. (2007). Antiplatelet properties of escitalopram in patients with the metabolic syndrome: A dose-ranging in vitro study. Neuropsychopharmacology, 32(11), 2369-74.