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Nancy Frasure-Smith, PhD

Dr Nancy Frasure-Smith is a Professor of Psychiatry at McGill, a Senior Research Associate at the Montreal Heart Institute and Invited Researcher at the CHUM Notre Dame. She has a cross-appointment in Nursing at McGill and in Psychiatry at the Université de Montréal. She completed her PhD in sociology at the Johns Hopkins University and postdoctoral training in psychology at McGill. Her current research program, carried out in conjunction with psychiatrists and cardiologists at McGill, the Université de Montréal and the Montreal Heart Institute, is concerned with:

  1. assessing the importance of psychological and social variables in the development and prognosis of cardiovascular disease;
  2. exploring physiological and behavioural mechanisms linking psychological and social variables with cardiovascular disease;
  3. developing and evaluating interventions to change the impact of psychological and social variables in cardiovascular disease.

nancy [dot] frasure-smith [at] mcgill [dot] ca (email) publications

Selected Articles

Frasure-Smith, N., Lespérance, F., Irwin, M. R., Sauvé, C., Lespérance, J., & Théroux, P. (2007). Depression, C-reactive protein and two-year major adverse cardiac events in men after acute coronary syndromes. Biological Psychiatry, 62, 302-308.

Lespérance, F., Frasure-Smith, N., Koszycki, D., Laliberté, M. A., van Zyl, L. T., Baker, B., Swenson, J. R., Ghatavi, K., Abramson, B.L., Dorion, P., & Guertin, M. C. (2007). Effects of citalopram and interpersonal psychotherapy on depression in coronary artery disease patients: The Canadian Cardiac Randomized Evaluation of Antidepressant and Psychotherapy Efficacy Trial (CREATE). JAMA, 297(4), 367-379.

Duan, Q. L., Dubé, M. P., Frasure-Smith, N., Barhdadi, A., Lespérance, F., Théroux, P., St-Onge, J., Rouleau, G. A., & McCaffery, J. M. (2007). Additive effects of obesity and TCF7L2 variants on risk for type 2 diabetes among cardiac patients.  Diabetes Care, 30, 1621-1623.

Atar, D., Malanin, A., Pokov, A., van Zyl, L., Frasure-Smith, N., Lespérance, F., & Serebruany, V. (2007). Antiplatelet properties of escitalopram in patients with the metabolic syndrome: A dose-ranging in vitro study. Neuropsychopharmacology, 32(11), 2369-74.

Frasure-Smith, N., & Lespérance F. (2008). Depression and anxiety as predictors of two-year cardiac events in patients with stable coronary artery disease. Archives of General Psychiatry, 65(1), 62-71.

Nigam, A., Frasure-Smith, N., Lespérance, F., & Juliene, P. (2009). Relationship between n-3 and n-6 plasma fatty acid levels and insulin resistance in coronary patients with and without metabolic syndrome. Nutrition, Metabolism & Cardiovascular Diseases, 19(4), 264-270.

Lichtman, J. H., Bigger, J. T., Blumenthal, J. A., Frasure-Smith, N., Kaufmann, P. G., Lespérance, F., Mark, D. B., Sheps, D. S., Taylor, C. B., & Froelicher, E. S. (2008). Depression and coronary heart disease. Recommendations for screening, referral, and treatment. A science advisory from the American Heart Association Prevention Committee of the Council on Cardiovascular Nursing, Council on Clinical Cardiology, Council on Epidemiology and Prevention, and Interdisciplinary Council on Quality of Care and Outcomes Research. Circulation 118(17), 1768-75.

Thombs, B., de Jonge, P., Coyne, J. C., Whooley, M. A., Frasure-Smith, N., Mitchell, A. J., Zuidersma, M., Eze-Nliam, C., Lima, B. B., Smith, C. G., Sodurlund, K., & Ziegelstein, R. (2008). Depression screening and patient outcomes in cardiovascular care: A systematic review. JAMA, 300(18), 2161-2171.

vanZyl, L., Lespérance, F., Frasure-Smith, N., Malinin, A. I., Atar, D., LaLiberté, M. A., & Serebruany, V. L. (2009). Platelet and endothelial activity in comorbid major depression and coronary artery disease patients treated with citalopram: The Canadian Cardiac Randomized Evaluation of Antidepressant and Psychotherapy Efficacy Trial (CREATE) Biomarker Sub-study. Journal of Thrombsois and Thrombolysis 27(1), 48-56.

McCaffery, J., Duan, Q. L., Frasure-Smith, N., Barhdadi, A., Lespérance, F., Théroux, P., Rouleau, G. A., & Dubé, M. P. (2009). Genetic predictors of depressive symptoms in cardiac patients. American Journal of Medical Genetics Part B (Neuropsychiatric Genetics), 150B(3), 381-8.

Frasure-Smith, N., Lespérance, F., Habra, M., Talajic, M., Khairy, P., Dorian, P., & Roy, D. (2009). For the Atrial Fibrillation and Congestive Heart Failure Investigators. Elevated depression symptoms predict long-term cardiovascular mortality in patients with atrial fibrillation and heart failure. Circulation, 120, 134-140.

Frasure-Smith, N., Lespérance, F., Irwin, M. R., Talajic, M., & Pollock, B. G. (2009). The relationships among heart rate variability, inflammatory markers and depression in coronary heart disease patients. Brain, Behavior and Immunity, 23, 1140-1147.

Cossette, S., D’Aoust, L. X., Morin, M., Frasure-Smith, N. (2009). The systematic development of a nursing intervention aimed at increasing enrolment in cardiac rehabilitation for acute coronary syndrome patients. Progress in Cardiovascular Nursing, 24, 71-79.

Houle, J., Beaulieu, M. D., Lespérance, F., Frasure-Smith, N., & Lambert, J. (2010). Inequities in medical follow-up for depression: A population-based study in Montreal. Psychiatric Services 61, 258-263.

Paradis, V., Cossette, S., Frasure-Smith, N., Heppell, S., & Guertin, M. C. (2010). The efficacy of a motivational nursing intervention based on the stages of change on self-care in heart failure patients. Journal of Cardiovascular Nursing, 25(2), 130-141. 

Lespérance, F., Frasure-Smith, N., St-André, E., Turecki, G., Lespérance, P., & Wisniewski, S. R. (2010). The efficacy of omega-3 supplementation for major depression: a randomized controlled trial. Journal of Clinical Psychiatry.

Habra, M. E., Baker, B., Frasure-Smith, N., Swenson, J. R., Koszycki, D., Butler, G., van Zyl, L. T., & Lespérance, F. (2010). First episode of major depressive disorder and vascular factors in coronary artery disease patients: Baseline characteristics and response to antidepressant treatment in the CREATE trial. Journal of Psychosomatic Research, 69(2) 133-41.

Frasure-Smith, N., & Lespérance, F. (2010). Depression and cardiac risk: Present status and future directions. [Editorial]. Heart, 96, 173-176. Reprinted in Postgraduate Medical Journal, 86, 193-196, 2010.  

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