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François Lespérance, MD

François Lespérance, MD

Dr Lespérance is a consultation-liaison psychiatrist and researcher based at the Montreal Heart Institute. His major areas of interest are the interaction of depression with cardiovascular function and adaptation after heart attack, work on which he collaborates with Dr N. Frasure-Smith.

francois [dot] lesperance [at] umontreal [dot] ca (email) website


Selected Articles

Davidson, K. W., Burg, M. M., Kronish, I. M., Shimbo, D., Dettenborn, L., Mehan, R., Vorchheimer, D., Clemow, L., Schwartz, J. E., Lespérance, F., & Rieckmann, N. (2010). Association of anhedonia with recurrent major adverse events and mortality 1 year after acute coronary syndrome. Archives of General Psychiatry, 67, 480-488.

Habra, M. E., Baker, B., Frasure-Smith, N., Swenson, R., Koszycki, D., Butler, G., vanZyl, L., & Lespérance, F. (2010). First episode of major depressive disorder and vascular factors in coronary artery disease patients: Baseline characteristics and response to antidepressant treatment in CREATE trial. Journal of Psychosomatic Research, 69(2), 133-141, 2010.

Lespérance, F., Frasure-Smith, N., St-André, É., Turecki, G., Lespérance, P., Wisniewski, S. R. (2010). The efficacy of omega-3 supplementation for major depression: A randomized controlled trial. Journal of clinical Psychiatry. Advance online publication. doi:10.4088/JCP.10m05966blu

Groleau, D., Whitley, R., Lespérance, F., & Kirmayer, L. J. (2010). Spiritual reconfigurations of self after a myocardial infarction: Influence of culture and place. Health and Place, 16(5), 853-860.

vanZyl, L., Lespérance, F., Frasure-Smith, N., Malinin, A. I., Atar, D., LaLiberté, M.-A., & Serebruany, V. L. (2009). Platelet and endothelial activity in comorbid major depression and coronary artery disease patients treated with citalopram: The Canadian Cardiac Randomized Evaluation of Antidepressant and Psychotherapy Efficacy Trial (CREATE) Biomarker Sub-study. Journal of Thrombosis and Thrombolysis, 27, 48-56.

McCaffery, J. M., Duan, Q. L., Frasure-Smith, N., Barhdadi, A., Lespérance, F., Théroux, P., Rouleau G., & Dubé, M.-P. (2009). Genetic predictors of depressive symptoms in cardiac patients. American Journal of Medical Genetics Part B (Neuropsychiatric Genetics), 150B, 381-388.

Nigam, A., Frasure-Smith, N., Lespérance, F., & Julien, P. (2009) Relationship between n-3 and n-6 plasma fatty acid levels and insulin resistance in coronary patients with and without metabolic syndrome. Nutrition, Metabolism & Cardiovascular Diseases 19(4), 264-270.

Lichtman, J. H., Bigger, J. T., Blumenthal, J. A., Frasure-Smith, N., Kaufmann, P. G., Lespérance, F., Mark, D. B., Sheps, D. S., Taylor, C. B., & Froelicher, E. S. (2009). AHA science advisory. Depression and coronary heart disease. Recommendations for screening, referral and treatment. A science advisory from the American Heart Association Prevention Committee to the Council on Cardiovascular Nursing, Council on Clinical Cardiology, Council of Epidemiology and prevention, and interdisciplinary Council on Quality of Care Outcomes Research. Endorsed by the American Psychiatric Association. Progress in Cardiovascular Nursing, 24, 19-26.

Frasure-Smith, N., Lespérance, F., Habra, M., Dorian, P., Talajic, M., Guerra, P. G., Roy, D. for the AF-CHF Investigators. (2009). Equivalent improvements in quality of life associated with rhythm and rate control strategies for atrial fibrillation in congestive heart failure (Results of the AF-CHF Trial). Canadian Journal of Cardiology.

Frasure-Smith, N., Lespérance, F., Habra, M., Talajic, M., Khairy, P., Dorian, P., & Roy, D. for the Arterial Fibrillation and Congestive Heart Failure Investigators. (2009). Elevated depression symptoms predict long-term cardiovascular mortality in patients with atrial fibrillation and heart failure. Circulation, 120(2), 134-140.

Frasure-Smith, N., Lespérance, F., Irwin, M. R., Talajic, M., & Pollock, B. G. (2009). The relationships among heart rate variability, inflammatory markers and depression in coronary heart disease patients. Brain Behavior & Immunity, 23(8), 1140-7.

Ravindran, A. V., Lam, R. W., Filteau, M.-J., Lesperance, F., Kennedy, S. H., Parikh, S. V., Patten, S. B. (2009). Canadian Network for the mood and anxiety treatments (CANMAT) clinical guidelines for the management of major depressive disorder in adults. V. Complementary and alternative medicine treatments. Journal of Affective Disorders, 117(Suppl 1), S54-64, 2009.

Frasure-Smith, N., & Lespérance, F. (2008). Depression and anxiety as predictors of two-year cardiac events in men with stable coronary artery disease. Archives of General Psychiatry, 65(1), 62-71.

Burg, M. M., Lespérance, F., Rieckmann, N., Clemow, L., Skotzko, C., & Davidson, K. W. (2008). Treating persistent depressive symptoms in post-ACS patients: The project COPES phase-I randomized controlled trial. Contemporary Clinical Trials, 29, 231-240.

Lichtman, J. H., Bigger, J. T., Blumenthal, J. A., Frasure-Smith, N., Kaufmann, P. G., Lespérance, F., Mark, D. B., Sheps, D. S., Taylor, C. B., & Froelicher, E. S. (2008). Depression and coronary heart disease : Recommendations for screening, referral and treatment: A science advisory from the American Heart Association Prevention Committee of the Council on Cardiovascular Nursing, Council on clinical cardiology, Council of Epidemiology and prevention, and interdisciplinary Council on Quality of Care and Outcomes Research endorsed by the American Psychiatric Association. Circulation 118, 1768-75. 

Lespérance, F., Frasure-Smith, N., Koszycki, D., Laliberté, M. A., van Zyl, L. T., Baker, B., Swenson, J. R., Ghatavi, K., Abramson, B. L., Dorian, P., & Guertin, M. C. (2007). Effects of citalopram and interpersonal psychotherapy on depression in coronary artery disease patients : The Canadian Cardiac Randomized Evaluation of Antidepressant and Psychotherapy efficacy (CREATE) trial. JAMA, 297, 367-379.

Frasure-Smith, N., Lespérance, F., Irwin, M. R., Sauvé, C., Lespérance, J., & Théroux, P. (2007). Depression, C-reactive protein and two-year major adverse cardiac events in men after acute coronary syndromes. Biological Psychiatry, 62, 302-308.

Frasure-Smith, N., Koszycki, D., Swenson, J. R., Baker, B., Van Zyl, L. T., Laliberté, M.-A., Abramson, B. L., Lambert, J., Gravel, G., & Lespérance, F. (2006). Design and rationale for a randomized, controlled trial of interpersonal psychotherapy and citalopram for depression in coronary artery disease (CREATE). Psychosomatic Medicine, 68(1), 87-93.

McCaffery, J.-M., Frasure-Smith, N., Dubé, M.-P., Théroux, P., Rouleau, G.-A., Duan, Q.-L., & Lespérance, F. (2006). Common genetic vulnerability to depressive symptoms and coronary artery disease : A review and development of candidate genes related to inflammation and serotonin. Psychosomatic Medicine 68(2), 187-200.

Davidson, K. W., Kupfer, D. J., Bigger, J. T., Califf, R. M., Carney, R. M., Coyne, J. C., Czjakowski, S., Frasure-Smith, N., Frank, E., Freedland, K. E., Froelicher, E. S., Glassmann, A. H., Kauffman, P., Kayton, W. J., Kessler, R. C., Kraemer, H. C., Krishnan, K. R., Lespérance, F., Rieckmann, N., Sheps, D. S., & Suls, J. M. (2006). Assessment and treatment of depression in patients with cardiovascular disease: National Heart, Lung, and Blood Institute Working Group report. Annals of Behavioral Medicine, 32, 121-126.

Rieckmann, N., Gerin, W., Kronish, I. M., Burg, M. M., Chaplin, W. F., Kong, G., Lespérance, F., & Davidson, K. W. (2006). Course of depressive symptoms and medication adherence after acute coronary syndromes: An electronic medication monitoring study. JACC 48(11), 2223-4.