World TB Day at McGill
March 24, 2018
This year's theme: "Wanted: Leaders for a TB-Free world" reminds us that all can be leaders of efforts to end TB in their own work or terrain.
See how you can make a difference
March 24th marks World TB Day. Tuberculosis (TB) is curable and preventable but continues to kill worldwide. According to the World Health Organization (WHO), there are more than 10 million of TB cases and 1.8 million deaths every year. For many years in Montreal, top research leaders have been working together under the umbrella of the McGill International TB Centre to better understand, diagnose and treat TB and other mycobacterial diseases.
Tuberculosis is caused by the bacteria Mycobacterium tuberculosis that most often affects the lungs. The infection spreads from person to person through the air. When someone develops active TB, the symptoms (cough, fever, night sweats, weight loss etc.) may be mild or nonexistent for many weeks. This can lead to delays in seeking care, and that can result in transmission of the bacteria to others. Without proper treatment, up to two thirds of people with TB will die.
MORE ON THE GLOBAL FIGHT AGAINST TB
TB-oriented and other courses at the McGill Summer Institute in Infectious Diseases and Global Health
Registration now Open
Canadian researchers’ innovative work promises to make vaccines more effective against tuberculosis and other infectious diseases like the flu.
"We can harness the power of stem cells in vaccine against TB". Through a fantastic collaboration between Dr. Divangahi and Dr. Barreiro's Lab, they showed that BCG reprogramming of stem cells generates trained immunity against TB.
"BCG educates hematopoietic stem cells to generate protective innate immunity against tuberculosis," Jan. 11, 2018, in Cell. DOI: 10.1016/j.cell.2017.12.031 For more info
Congratulations to Dr. Madhukar Pai and his team, awarded support from Grand Challenges Canada for pioneering work to improve the diagnosis of TB in children under the age of 15. Grand Challenges Canada named the team as one of the top 20 Canadian ideas to improve maternal and child health.
Congratulations to TB Centre trainees Jean-Yves Dube (Behr group), Jeffrey Downey (Divangahi group) and Madlen Nash (Pai Group) who were awarded RI MUHC Studentships or Fellowships for 2018!
McGill Research influences WHO TB policies
WHO has just released new clinical guidelines for treatment of INH-resistant TB (based in part on the work of Dr Dick Menzies and others at McGill, Montreal). Isoniazid-resistant TB, without concurrent rifampicin resistance, is estimated to occur in about 8% of people with TB globally. A regimen of 6 months rifampicin, ethambutol, pyrazinamide and levofloxacin is now recommended in adults and children diagnosed with this type of drug-resistant TB. Resistance to rifampin and fluoroquinolones should be ruled out before using this regimen.
Introducing N-TB, an app for nutritional assessment & counselling of patients with tuberculosis
On World TB Day, the Center for Nutrition Studies, Yenepoya University, Mangalore in association with McGill International TB Centre, Montreal will announce the public release of N-TB, an android mobile based application for the nutritional assessment and counseling of adult patients with TB. This app, endorsed by the Revised National Tuberculosis Control Programme and WHO India, was included in the new initiatives unveiled by Prime Minister Narendra Modi during the Delhi End TB Summit held in March. Download the App for free on Google Play
Great job at knowledge synthesis by TB Centre researchers:
Just got designated as a ‘Highly cited paper’ by the Web of Science, meaning it is among the top 1% of papers of similar age in the field of clinical medicine! Read it here: http://go.nature.com/2Da2w2q
McGill authors topped the rankings as first and corresponding authors in systematic reviews and meta-analyses in TB research.
According to a study, McGill researchers account for 6% of the world's best cited TB papers which is very high ranking! The 100 top-cited tuberculosis research https://www.atsjournals.org/doi/10.1164/rccm.201707-1489PPstudies (International Union Against Tuberculosis and Lung Disease) Download
Post Doctoral Fellowship Positions in Tuberculosis Research Available:
Recent TB Articles/Publications
Comparison of different treatments for isoniazid resistant tuberculosis: an individual patient data meta-analysis. The Lancet Respiratory Medicine
Cracking the Vaccine Code. Am J Respir Crit Care Med
Tuberculosis: a Persistent Health Challenge for India. Current Epid Reports
- Ego is the Enemy, especially for Academics
- Avis de recherche: chefs de file pour un monde exempt de tuberculose
- A new app for nutritional assessment & counselling of patients with TB
- Hope rises for a world free of TB
- India's tuberculosis research contributions get international recognition
- Eniethi’nikonhraiéntho’: “We’ll plant a seed in their minds”
- Meet RIPK3: Good Cop, Bad Cop, all rolled in one
- Re-programming innate immune cells to fight tuberculosis
- The stigma of Tuberculosis is a harsh reminder of the social injustices faced by women
- Childhood tuberculosis: Montreal researchers advancing the fight
- McGill International TB Centre supports innovative initiatives in high-burden regions
- Click here for more
Our centre brings together over 20 investigators with expertise spanning epidemiology, policy setting, economic analyses, implementation research, meta-analyses, qualitative research to basic science in microbiology, host genetics and immune response.
The work is done both at an academic centre and with a number of collaborating groups around the world. On these pages, we introduce the faculty members who are members of our centre and describe our training programs for students. Find out why our Centre is a world leader in the interdisciplinary study of TB and how we work together to unravel the many mysteries of this recalcitrant disease.