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Doctor of Philosophy (Ph.D.); Pharmacology — Chemical Biology

Offered by: Pharmacology and Therapeutics     Degree: Doctor of Philosophy

Program Requirements

Thesis

A thesis for the doctoral degree must constitute original scholarship and must be a distinct contribution to knowledge. It must show familiarity with previous work in the field and must demonstrate ability to plan and carry out research, organize results, and defend the approach and conclusions in a scholarly manner. The research presented must meet current standards of the discipline; as well, the thesis must clearly demonstrate how the research advances knowledge in the field. Finally, the thesis must be written in compliance with norms for academic and scholarly expression and for publication in the public domain.

Required Courses (13 credits)

  • BIOC 610 Seminars in Chemical Biology 1 (1 credit)

    Offered by: Biochemistry (Faculty of Medicine)

    Administered by: Graduate Studies

    Overview

    Biochemistry : First multidisciplinary seminar in chemical biology.

    Terms: Fall 2013, Winter 2014

    Instructors: John R Silvius (Fall) John R Silvius (Winter)

    • Restrictions: Open only to students registered for the M.Sc. or Ph.D. Graduate Option in Chemical Biology.
  • BIOC 611 Seminars in Chemical Biology 3 (1 credit)

    Offered by: Biochemistry (Faculty of Medicine)

    Administered by: Graduate Studies

    Overview

    Biochemistry : Third multidisciplinary seminar in chemical biology.

    Terms: Fall 2013, Winter 2014

    Instructors: John R Silvius (Fall) John R Silvius (Winter)

    • Restrictions: Open only to students registered for the M.Sc. or Ph.D. Graduate Option in Chemical Biology.
  • BIOC 689 Seminars in Chemical Biology 2 (1 credit)

    Offered by: Biochemistry (Faculty of Medicine)

    Administered by: Graduate Studies

    Overview

    Biochemistry : Second multidisciplinary seminar in chemical biology.

    Terms: Fall 2013, Winter 2014

    Instructors: John R Silvius (Fall) John R Silvius (Winter)

    • Restrictions: Open only to students registered for the M.Sc. or Ph.D. Graduate Option in Chemical Biology. Not open to students who have taken CHEM 689.
  • BIOC 690 Seminars in Chemical Biology 4 (1 credit)

    Offered by: Biochemistry (Faculty of Medicine)

    Administered by: Graduate Studies

    Overview

    Biochemistry : Fourth multidisciplinary seminar in chemical biology.

    Terms: Fall 2013, Winter 2014

    Instructors: John R Silvius (Fall) John R Silvius (Winter)

    • Restrictions: Open only to students registered for the M.Sc. or Ph.D. Graduate Option in Chemical Biology. Not open to students who have taken CHEM 690.
  • PHAR 601 Comprehensive (6 credits)

    Offered by: Pharmacology and Therapeutics (Faculty of Medicine)

    Administered by: Graduate Studies

    Overview

    Pharmacology and Therapeutics

    Terms: Winter 2014, Fall 2013

    Instructors: There are no professors associated with this course for the 2013-2014 academic year.

  • PHAR 712 Statistics for Pharmacologists (3 credits)

    Offered by: Pharmacology and Therapeutics (Faculty of Medicine)

    Administered by: Graduate Studies

    Overview

    Pharmacology and Therapeutics : Basic theoretical and practical aspects of statistics for pharmacologists.

    Terms: Winter 2014

    Instructors: Paul Clarke (Winter)

    • Restriction: This course is restricted to graduate students in Pharmacology and Therapeutics. Others require permission of the course coordinator.

Complementary Courses (14 credits)

6 credits, from the following courses:

  • PHAR 562 General Pharmacology 1 (3 credits)

    Offered by: Pharmacology and Therapeutics (Faculty of Science)

    Overview

    Pharmacology and Therapeutics : Topics in pharmacology with an emphasis on molecular aspects and the nervous system; topics include molecular mechanisms of drug-action, cellular targets and rationale for therapeutics.

    Terms: Fall 2013

    Instructors: Guillermina Almazan, Paul Clarke (Fall)

    • Fall
    • Prerequisite: PHAR 301.
    • Restriction: Open to U3 students in the minor, major or honours program in Pharmacology, or with permission of instructor.
  • PHAR 563 General Pharmacology 2 (3 credits)

    Offered by: Pharmacology and Therapeutics (Faculty of Science)

    Overview

    Pharmacology and Therapeutics : Selected topics in pharmacology of the endocrine, metabolic, and cardiovascular systems. Additional topics include: pharmacogenetics/pharmacogenomics, chronopharmacology, molecular structure in pharmacology, epigenetic targets in cancer chemotherapy, and stem cell therapies.

    Terms: Winter 2014

    Instructors: Daniel Bernard (Winter)

    • Winter
    • Prerequisite: PHAR 301.
    • Restriction: Open to U3 students in the minor, major or honours program in Pharmacology, or with permission of instructor.

or, for students who have taken PHAR 562 and PHAR 563 as part of their undergraduate degree, they can replace them with two of the following courses:

  • BIOC 603 Genomics and Gene Expression (3 credits)

    Offered by: Biochemistry (Faculty of Medicine)

    Administered by: Graduate Studies

    Overview

    Biochemistry : Examination of recent developments in analysis of eukaryotic cell genomes and control of gene expression. Molecular genetics; genomics and the bioinformatics of analysis of genomic and functional-genomic data; mechanisms and signal-transduction pathways for regulation of gene expression; applications to human disease.

    Terms: Fall 2013

    Instructors: William Joseph Muller, Imed Eddine Gallouzi, Maxime Bouchard (Fall)

    • Fall
    • Prerequisites: BIOC 454 and permission of instructor.
  • BIOC 604 Macromolecular Structure (3 credits)

    Offered by: Biochemistry (Faculty of Medicine)

    Administered by: Graduate Studies

    Overview

    Biochemistry : X-Ray crystallography, NMR spectroscopy, computational methods and theoretical approaches to the determination and analysis of macromolecular structures. Theory and practical applications will be covered. Examples will include interpretation of structure as it applies to biological functions. In conjunction with the Université de Montréal.

    Terms: Winter 2014

    Instructors: Bhushan Nagar, Thomas Martin Schmeing, Kalle Burgess Gehring (Winter)

    • Winter
    • Prerequisite: BIOC 450 or equivalent
    • Lectures in French and English
    • Offered in the Fall term, in even alternate years.
  • CHEM 504 Drug Design and Development 2 (3 credits)

    Offered by: Chemistry (Faculty of Science)

    Overview

    Chemistry : Computational methods used in drug design and discovery including QSAR, docking/scoring, molecular mechanics and molecular dynamics, QM/MM, library profiling and library design.

    Terms: This course is not scheduled for the 2013-2014 academic year.

    Instructors: There are no professors associated with this course for the 2013-2014 academic year.

    • Winter
    • Prerequisite: CHEM 503 and permission of instructor
    • Restriction: U3 and graduate students. Students can register only with permission of coordinators
  • CHEM 522 Stereochemistry (3 credits)

    Offered by: Chemistry (Faculty of Science)

    Overview

    Chemistry : Stereoisomers, their nomenclature and configuration. Conformational analysis, separation of stereoisomers, and stereocontrol in organic synthesis.

    Terms: Fall 2013

    Instructors: Nicolas Moitessier (Fall)

    • Winter
    • Prerequisite: CHEM 302
    • Restriction: Not open to students who have taken CHEM 623
  • CHEM 591 Bioinorganic Chemistry (3 credits)

    Offered by: Chemistry (Faculty of Science)

    Overview

    Chemistry : The roles of transition and main group elements in biology and medicine will be examined with an emphasis on using tools for structure and genome searching as well as becoming acquainted with experimental spectroscopic methods useful for bioinorganic chemistry such as macromolecular X-ray diffraction, EPR and EXAFS.

    Terms: This course is not scheduled for the 2013-2014 academic year.

    Instructors: There are no professors associated with this course for the 2013-2014 academic year.

    • Winter
    • Prerequisite: CHEM 381
    • Restriction: For Honours and Major Chemistry students or with permission
  • CHEM 621 Reaction Mechanisms in Organic Chemistry (5 credits)

    Offered by: Chemistry (Faculty of Science)

    Administered by: Graduate Studies

    Overview

    Chemistry : A systematic survey of the mechanisms of the most common organic reactions from studies of reactions in the current literature.

    Terms: Fall 2013

    Instructors: Chaojun Li (Fall)

  • CHEM 629 Organic Synthesis (5 credits)

    Offered by: Chemistry (Faculty of Science)

    Administered by: Graduate Studies

    Overview

    Chemistry : An advanced course in the synthesis of organic molecules with an emphasis on stereoselective transformations. Topics will include multiple bond formation, functional group interconversions, carbon-carbon bond formation and stereoselective oxidations and reductions.

    Terms: Winter 2014

    Instructors: Jean-Philip Lumb (Winter)

  • CHEM 655 Advanced NMR Spectroscopy (4 credits)

    Offered by: Chemistry (Faculty of Science)

    Administered by: Graduate Studies

    Overview

    Chemistry : Advanced techniques of nuclear magnetic resonance spectroscopy, Fourier transform methods, multiple pulsing, two-dimensional pulse sequencing.

    Terms: This course is not scheduled for the 2013-2014 academic year.

    Instructors: There are no professors associated with this course for the 2013-2014 academic year.

    • 1 lecture
    • Prerequisite: CHEM 555 or equivalent.
  • PHAR 504 Drug Discovery and Development 2 (3 credits)

    Offered by: Pharmacology and Therapeutics (Faculty of Science)

    Overview

    Pharmacology and Therapeutics : Nobel Prize-winning discoveries as a basis for drug development.

    Terms: Winter 2014

    Instructors: Dusica Maysinger, Lisa Munter (Winter)

    • Winter
    • Prerequisites: PHAR 301 or PHAR 303; or permission of instructor
    • Restriction: U3 and graduate students. Students can register only with permission of coordinators.
  • PHAR 707 Topics in Pharmacology 6 (3 credits)

    Offered by: Pharmacology and Therapeutics (Faculty of Medicine)

    Administered by: Graduate Studies

    Overview

    Pharmacology and Therapeutics : Topics in pharmacology.

    Terms: This course is not scheduled for the 2013-2014 academic year.

    Instructors: There are no professors associated with this course for the 2013-2014 academic year.

    • Prerequisite: Permission of the Instructor.

two of the following courses:

  • PHAR 700 Seminars in Pharmacology (3 credits)

    Offered by: Pharmacology and Therapeutics (Faculty of Medicine)

    Administered by: Graduate Studies

    Overview

    Pharmacology and Therapeutics : This course is organized in conjunction with the weekly Departmental Seminar Series and consists of (1) regular attendance of the weekly Departmental research seminars, (2) active participation in lunch tutorials organized with seminar speakers following the seminar and (3) production of written reports on selected seminars.

    Terms: This course is not scheduled for the 2013-2014 academic year.

    Instructors: There are no professors associated with this course for the 2013-2014 academic year.

    • Prerequisites: PHAR562 and PHAR 563, unless the student has been exempted previously from these courses by the Graduate Teaching Committee.
    • Restriction: Students enrolled in the Departmental graduate program at the level of M.Sc. 2 or Ph.D. are admissible. Exemptions from this restriction are possible if approved by the Graduate Teaching Committee.
  • PHAR 702 Topics in Pharmacology 1 (3 credits)

    Offered by: Pharmacology and Therapeutics (Faculty of Medicine)

    Administered by: Graduate Studies

    Overview

    Pharmacology and Therapeutics : Topics in pharmacology.

    Terms: Fall 2013

    Instructors: Bernard Robaire, Daniel Bernard (Fall)

    • Prerequisite: Permission of the Instructor.
  • PHAR 703 Topics in Pharmacology 2 (3 credits)

    Offered by: Pharmacology and Therapeutics (Faculty of Medicine)

    Administered by: Graduate Studies

    Overview

    Pharmacology and Therapeutics : Topics in pharmacology.

    Terms: This course is not scheduled for the 2013-2014 academic year.

    Instructors: There are no professors associated with this course for the 2013-2014 academic year.

    • Prerequisite: Permission of the Instructor.
  • PHAR 704 Topics in Pharmacology 3 (3 credits)

    Offered by: Pharmacology and Therapeutics (Faculty of Medicine)

    Administered by: Graduate Studies

    Overview

    Pharmacology and Therapeutics : Topics in pharmacology.

    Terms: This course is not scheduled for the 2013-2014 academic year.

    Instructors: There are no professors associated with this course for the 2013-2014 academic year.

    • Prerequisite: Permission of the Instructor.
  • PHAR 705 Topics in Pharmacology 4 (3 credits)

    Offered by: Pharmacology and Therapeutics (Faculty of Medicine)

    Administered by: Graduate Studies

    Overview

    Pharmacology and Therapeutics : Topics in pharmacology.

    Terms: This course is not scheduled for the 2013-2014 academic year.

    Instructors: There are no professors associated with this course for the 2013-2014 academic year.

    • Prerequisite: Permission of the Instructor.
  • PHAR 706 Topics in Pharmacology 5 (3 credits)

    Offered by: Pharmacology and Therapeutics (Faculty of Medicine)

    Administered by: Graduate Studies

    Overview

    Pharmacology and Therapeutics : Topics in pharmacology.

    Terms: This course is not scheduled for the 2013-2014 academic year.

    Instructors: There are no professors associated with this course for the 2013-2014 academic year.

    • Prerequisite: Permission of the Instructor.
  • PHAR 707 Topics in Pharmacology 6 (3 credits)

    Offered by: Pharmacology and Therapeutics (Faculty of Medicine)

    Administered by: Graduate Studies

    Overview

    Pharmacology and Therapeutics : Topics in pharmacology.

    Terms: This course is not scheduled for the 2013-2014 academic year.

    Instructors: There are no professors associated with this course for the 2013-2014 academic year.

    • Prerequisite: Permission of the Instructor.

one of the following courses:

  • CHEM 502 Advanced Bio-Organic Chemistry (3 credits)

    Offered by: Chemistry (Faculty of Science)

    Overview

    Chemistry : This course will cover biologically relevant molecules, particularly nucleic acids, proteins, and their building blocks. In each case, synthesis and biological functions will be discussed. The topics include synthesis of oligonucleotides and peptides; chemistry of phosphates; enzyme structure and function; coenzymes, and enzyme catalysis; polyketides; antiviral and anticancer agents.

    Terms: Winter 2014

    Instructors: Karine Auclair, Laura Pavelka (Winter)

    • Winter
    • Prerequisite: CHEM 302
    • Restriction: Not open to students who have taken CHEM 402.
  • PHAR 503 Drug Discovery and Development 1 (3 credits)

    Offered by: Pharmacology and Therapeutics (Faculty of Science)

    Overview

    Pharmacology and Therapeutics : Chemistry, mechanisms of action, and steps in drug discovery and development.

    Terms: Fall 2013

    Instructors: Dusica Maysinger, Lisa Munter (Fall)

    • Fall
    • Prerequisites: PHAR 301 or PHAR 303; or permission of instructor
Faculty of Medicine—2013-2014 (last updated Jul. 30, 2013) (disclaimer)