Dystroglycan-dependent homeostatic plasticity at hippocampal inhibitory synapses - NSCI 396 Undergraduate Research Project Application Form

Supervisor's Name: David Stellwagen

Supervisor's Email: david.stellwagen [at] mcgill.ca

Supervisor's Phone:

Supervisor's Website:

Supervisor's department: Neurology & Neurosurgery

Course number: NSCI 396 (Neuroscience)

Term: Summer 2014

Project start date: May 5th, 2014

Project end date: August 15th, 2014

Project title: Dystroglycan-dependent homeostatic plasticity at hippocampal inhibitory synapses

Project description (50-100 words suggested): Homeostatic plasticity is essential for the regulation and maintenance of stable neural function. It is very important during prolonged periods of high neuronal firing rate. Over time, a high neuronal firing rate is restored to normal levels, in part by compensatory changes in excitatory and inhibitory synaptic strengths. Though many such mechanisms have been characterized for homeostatic plasticity at excitatory synapses, corresponding mechanisms at inhibitory synapses are not as well defined. The goal of this project is to investigate the role of dystroglycan, an important scaffolding molecule found at central GABAergic synapses – in homeostatic plasticity at hippocampal inhibitory synapses.

Prerequisite: 1 term completed at McGill + CGPA of 3.0 or higher; or permission of instructor.

Grading scheme (The final report must be worth at least 50% of final grade): Final grade shall be based on an evaluation of laboratory (or equivalent) performance (40%), a final written report (50%), and an oral presentation (10%) by the supervisor.

Project status: This project is taken. The professor has no more '396' projects this term.

Ethics, safety, and training: Supervisors are responsible for the ethics and safety compliance of undergraduate students. This project involves: Handling chemicals.