Effects of antidepressants on the expression of DCC - NSCI 396 Undergraduate Research Project Application Form

Supervisor's Name: Cecilia Flores

Supervisor's Email: cecilia.flores [at] mcgill.ca

Supervisor's Phone: (514) 761-6131 ext office: 2814

Supervisor's Website: http://ceciliafloreslab.com/

Supervisor's department: Psychiatry, Neurology and Neurosurgery

Course number: NSCI 396 (Neuroscience)

Term: Summer 2014

Project start date: May 1, 2014

Project end date: August 31, 2014

Project title: Effects of antidepressants on the expression of DCC

Project description (50-100 words suggested): Adolescence is a critical period in which the prefrontal cortex (PFC) undergoes substantial maturational changes. Our group has demonstrated that altered expression of dcc during adolescence leads to morphological and functional reorganization of the PFC. Dysfunction of the PFC is associated with the development of psychiatric disorders, including depression. Remarkably, vulnerability for these disorders is heightened during adolescence. The aim of this project is to evaluate if antidepressant exposure during adolescence regulates the short-term and long-term expression of DCC, leading to functional changes in the PFC.

Prerequisite: 1 term completed at McGill + CGPA of 3.0 or higher; or permission of instructor.

Grading scheme (The final report must be worth at least 50% of final grade): 50% Lab work; 50% Final report

Project status: This project is taken. The professor has no more '396' projects this term.

Ethics, safety, and training: Supervisors are responsible for the ethics and safety compliance of undergraduate students. This project involves: Animal subjects.