'Examining the gating properties of purinergic P2X4 receptors' - PHGY 396 Undergraduate Research Project Application Form

Supervisor's Name: Anmar Khadra

Supervisor's Email: anmar.khadra [at] mcgill.ca

Supervisor's Phone: 514-398-1743

Supervisor's Website: www.medicine.mcgill.ca/physio/khadralab/

Supervisor's department: Physiology

Course number: PHGY 396 (Physiology)

Term: Winter 2013-2014

Project start date: Monday, January 6, 2014

Project end date: Friday, April 11, 2014

Project title: Examining the gating properties of purinergic P2X4 receptors.

Project description (50-100 words suggested): P2X4 receptors are ATP-gated non-selective cation channels. They play roles in neurotransmission, inflammation and chronic pain, and possess three ATP-binding sites that, when occupied, lead to receptor activation and channel opening. The gating properties of these receptors are incompletely understood. In this project, we plan to use biophysical and mathematical approaches to understand the gating properties of these receptors, including sensitization and desensitization, under various ionic conditions. Using Markov Chain Monte Carlo methods, we will conduct systematic model comparisons and parameter optimization methods to determine the most likely model and parameter set(s) based on data.

Prerequisite: 1 term completed at McGill + CGPA of 3.0 or higher; or permission of instructor.

Grading scheme (The final report must be worth at least 50% of final grade): Oral presentation 10%; Performance in the project: 40%; Final report: 50%

Project status: This project is taken; however students may contact the professor to discuss other possible '396' projects this term.

How students can apply / Next steps: Bring a printed copy of this application form and your advising transcript to me during office hours.

Ethics, safety, and training: Supervisors are responsible for the ethics and safety compliance of undergraduate students. This project involves NEITHER animal subjects, nor human subjects, nor biohazardous substances, nor radioactive materials, nor handling chemicals, nor using lasers.