Supervisor's Name: Dr. Ciriaco Piccirillo
Supervisor's Email: ciro.piccirillo [at] mcgill.ca
Supervisor's department: Microbiology and Immunology
Course number: MIMM 397 (Immunology)
Term: Winter 2013-2014
Project start date: Monday, January 6, 2014
Project end date: Friday, April 11, 2014
Project title: Identification of novel biomarkers of functional FOXP3+ Treg cells in humans
Project description (50-100 words suggested): Specific markers of FOXP3+ Treg cells in humans are currently lacking. While Treg-associate markers like CD25 and FOXP3 are routinely used to discriminate Treg from conventional effector T cells, these markers become unreliable in instances of immune activation and inflammation as they are readily upregulated on conventional cells. A recently described single-cell platform coupled with whole genome transcriptomics has enabled the Piccirillo lab to identify new cell surface antigens which discriminate these functional subsets. My project will consist in the phenotypic and functional validation of these new Treg markers.
Prerequisite: 1 term completed at McGill + CGPA of 3.0 or higher; or permission of instructor.
Grading scheme (The final report must be worth at least 50% of final grade): Final grade shall be based on laboratory performance as evaluated by the research supervisor (50%) and the final written research report (minimum 10 pages) graded by the supervisor and the course coordinator or the coordinator's delegate (50%).
Project status: This project is taken. The professor has no more '396' projects this term.
How students can apply / Next steps: After all parts of this application form are completed, and the hard copy is signed by the professor and the student, bring this application form and your unofficial transcript to Prof. Gregory Marczynski during office hours, who will review/approve as the course coordinator for MIMM 396 (Microbiology) or MIMM 397 (Immunology).
Ethics, safety, and training: Supervisors are responsible for the ethics and safety compliance of undergraduate students. This project involves: Biohazardous substances; Using lasers.