Characterizing the capacity of mammary tumours to suppress dendritic cell function - MIMM 397 Undergraduate Research Project Application Form

Supervisor's Name: Dr. Connie Michele Krawczyk

Supervisor's Email: connie.krawczyk [at] mcgill.ca

Supervisor's Phone:

Supervisor's Website:

Supervisor's department: Microbiology and Immunology

Course number: MIMM 397 (Immunology

Term: Winter 2013-2014

Project start date: Monday, January 6, 2014

Project end date: Friday, April 11, 2014

Project title: Characterizing the capacity of mammary tumours to suppress dendritic cell function.

Project description (50-100 words suggested): It is well-understood that tumour cells can create an immunosuppressive environment which promotes their growth. Dendritic cells, which are important for the activation of immunity, are known to be suppressed by some tumours. What is not known is the relationship between dendritic cell suppression and anti-tumour immunity, and whether dendritic cell suppression itself contributes to and reinforces the immunosuppressive microenvironment. We will examine the relationship between tumour cells and dendritic cells. Dendritic cells will be exposed to factors that are secreted by tumour cells and examined for their ability to become activated, and stimulate the activation of T cells.Prerequisite: 1 term completed at McGill + CGPA of 3.0 or higher; or permission of instructor.

Grading scheme (The final report must be worth at least 50% of final grade): Final grade shall be based on laboratory performance as evaluated by the research supervisor (50%) and the final written research report (minimum 10 pages) graded by the supervisor and the course coordinator or the coordinator's delegate (50%).

Project status: This project is taken. The professor has no more '396' projects this term.

How students can apply / Next steps: After all parts of this application form are completed, and the hard copy is signed by the professor and the student, bring this application form and your unofficial transcript to Prof. Gregory Marczynski during office hours, who will review/approve as the course coordinator for MIMM 396 (Microbiology) or MIMM 397 (Immunology).

Ethics, safety, and training: Supervisors are responsible for the ethics and safety compliance of undergraduate students. This project involves NEITHER animal subjects, nor human subjects, nor biohazardous substances, nor radioactive materials, nor handling chemicals, nor using lasers.