'Characterization of miRNA expression in differentially activated DCs.' - MIMM 397 Undergraduate Research Project Application Form

Supervisor's Name: Connie Krawczyk

Supervisor's Email: connie.krawczyk [at] mcgill.ca

Supervisor's Phone: 514 398 1376

Supervisor's Website:

Supervisor's department: Microbiology and Immunology

Course number: MIMM 397 (Immunology)

Term: Fall 2013-2014

Project start date: Tuesday, September 3, 2013

Project end date: Tuesday, December 3, 2013

Project title: Characterization of miRNA expression in differentially activated DCs.

Project description (50-100 words suggested): Dendritic cells become differentially activated depending on the type of stimulus they encounter. The activation phenotype depends on regulation of gene expression at both the level of transcription and translation. Recently, miRNAs have been shown to key regulators of gene expression by either silencing mRNA translation or targeting mRNA for degradation. We propose to characterize the differential expression of miRNAs following treatment of dendritic cells with various stimuli. miRNAs of interested will be identified and followed up for functional analysis.

Prerequisite: 1 term completed at McGill + CGPA of 3.0 or higher; or permission of instructor.

Grading scheme (The final report must be worth at least 50% of final grade): Final grade shall be based on laboratory performance as evaluated by the research supervisor (50%) and the final written research report (minimum 10 pages) graded by the supervisor and the course coordinator or the coordinator's delegate (50%).

Project status: This project is taken. The professor has no more '396' projects this term.

Ethics, safety, and training: Supervisors are responsible for the ethics and safety compliance of undergraduate students. This project involves: Animal subjects; Biohazardous substances.