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Genetic analyses of proposed hereditary factors in ovarian cancers - HGEN 396 Undergraduate Research Project Application Form

INSTRUCTIONS - PROFESSORS: Please print and review this form. Complete or correct the sections, as applicable, from "Supervisor's Name" to "Ethics, safety, and training". Please sign and date near the bottom ("Supervisor's signature").

INSTRUCTIONS - STUDENTS: You may receive this form by email, or you may download it after it has been posted here. Either way, print and review this form. Complete or correct the sections, from "Student's Name" to "Student's Level", and sign ("Student signature"). Ask your supervisor to sign her/his section near the bottom. Take it to the department* corresponding to the course number in Section A; this may or may not be your own department. (* EXCEPTIONS: For NSCI 396 and COGS 396, please bring it to the Interdisciplinary Programs Adviser in Dawson Hall.) Do not register for a '396' course on Minerva until you receive departmental permission. Have a discussion with your supervisor about time/work expectations, keeping in mind that this is a 3-credit course (roughly, 10 hours per week for 12 weeks). Remember that a '396' course is an elective.

INSTRUCTIONS - DEPARTMENTS: After the unit chair/director/designate approves (or not) this project, please notify student. If approved, please give student permission to register on Minerva, and send a copy of this form (with signatures) to the Office for Undergraduate Research in Science (either fax, or internal mail to Dawson Hall 408-A, or PDF scan + email).

QUESTIONS OR FEEDBACK? Contact the Office for Undergraduate Research in Science.

Supervisor's Name: Patricia Tonin

Supervisor's Email: patricia [dot] tonin [at] mcgill [dot] ca

Supervisor's Phone: (514) 934-1934 ext. 44069

Supervisor's Website: www.toninlab.mcgill.ca

Supervisor's department: Human Genetics

Supervisor's department (if none of the above):

Course number: HGEN 396 (Human Genetics)

Term: Summer 2014

Project start date: TBD - Between May-Aug 2014

Project end date: TBD - Between May-Aug 2014

Project title: Genetic analyses of proposed hereditary factors in ovarian cancers

Project description (50-100 words suggested): About 10-20% of ovarian cancers are due to the inheritance of germline mutations in the breast and ovarian cancer susceptibility genes, BRCA1 and BRCA2. Recently, new genetic factors have been proposed to confer risk to hereditary ovarian cancer. Though rarely mutated they collectively may account for up to 5% of hereditary cases. Our group has identified a new candidate genes using whole exome genome sequencing of familial ovarian cancer cases that do not harbor mutations in BRCA1 or BRCA2. The objective of the research project would be use bioinformatics resources to select one of the gene candidates identified by exome sequencing and genotype the variant in a set of well-defined ovarian cancer specimens in order to assay the frequency of the variant and assess its relevance as a candidate. The student will be paired with an experienced post-doctoral fellow who will train the student in applying bioinformatics resources for genomic sequencing derived data and performing genotyping assays.

Prerequisite: 1 term completed at McGill + CGPA of 3.0 or higher; or permission of instructor.

Grading scheme (The final report must be worth at least 50% of final grade): Final grade shall be based on an evaluation of laboratory (or equivalent) performance (40%), a final written report (50%), and an oral presentation (10%) by the supervisor. Details of the evaluation scheme will be provided by HGEN to supervisors and applicants

Other project information: For further information about research areas in the lab view www.toninlab.mcgill.ca

Project status: This project is taken.

How students can apply / Next steps: After all of the parts of this application forms are completed and the hard copy is signed by the professor and the student, bring the application form and a copy of your unofficial transcript to the Department of Human Genetics (to the attention of Dr. Patricia N. Tonin, Stewart Biology Building N5.13) during office hours.

Ethics, safety, and training: Supervisors are responsible for the ethics and safety compliance of undergraduate students. This project involves: Biohazardous substances; Handling chemicals.

Student's Name:

Student's McGill ID:

Student's McGill Email:

Student's Phone:

Student's Program:

Student's Level (U0 / U1 / U2 / U3):

Student's signature - I certify that this course is with a different supervisor and on a different topic than any previous '396' course I have taken. I have not applied for another '396' course in this term:

Supervisor's signature - I give my permission for the student identified above to register for this project under my supervision:


Unit chair/director/designate's name:

Unit chair/director/designate's signature - I certify that this project conforms to departmental requirements for 396 courses: