'Glucose Transporter Expression in SCG' - PHGY 396 Undergraduate Research Project Application Form
INSTRUCTIONS - PROFESSORS: Please print and review this form. Complete or correct the sections, as applicable, from "Supervisor's Name" to "Ethics, safety, and training". Please sign and date near the bottom ("Supervisor's signature").
INSTRUCTIONS - STUDENTS: You may receive this form by email, or you may download it after it has been posted here. Either way, print and review this form. Complete or correct the sections, from "Student's Name" to "Student's Level", and sign ("Student signature"). Ask your supervisor to sign her/his section near the bottom. Take it to the department* corresponding to the course number in Section A; this may or may not be your own department. (* EXCEPTIONS: For NSCI 396 and COGS 396, please bring it to the Interdisciplinary Programs Adviser in Dawson Hall.) Do not register for a '396' course on Minerva until you receive departmental permission. Have a discussion with your supervisor about time/work expectations, keeping in mind that this is a 3-credit course (roughly, 10 hours per week for 12 weeks). Remember that a '396' course is an elective.
INSTRUCTIONS - DEPARTMENTS: After the unit chair/director/designate approves (or not) this project, please notify student. If approved, please give student permission to register on Minerva, and send a copy of this form (with signatures) to the Office for Undergraduate Research in Science (either fax, or internal mail to Dawson Hall 408-A, or PDF scan + email).
QUESTIONS OR FEEDBACK? Contact the Office for Undergraduate Research in Science.
Supervisor's Name: Dr. Ellis Cooper
Supervisor's Email: ellis [dot] cooper [at] mcgill [dot] ca
Supervisor's Phone: 514 398 4334
Supervisor's department: Physiology
Course number: PHGY 396 (Physiology)
Term: Winter 2013-2014
Project start date: Monday, January 6, 2014
Project end date: Friday, April 11, 2014
Project title: Glucose Transporter Expression in SCG
Project description (50-100 words suggested): In mammalian cells, glucose is taken up through facilitative glucose transporters (GLUTs) and metabolized for energy. Excess extracellular glucose is toxic to cells and most individuals suffering from diabetes develop severe complications, particularly in the sympathetic nervous system. Conceivably, glucose uptake could be regulated by targeting GLUTs. However, it is unknown which of the fourteen GLUT members are expressed in sympathetic neurons. Recent results indicate that GLUT1, GLUT3, GLUT6, GLUT8, and GLUT13 are expressed in superior cervical ganglia (SCG) neurons, with GLUT3 being predominantly expressed. This project aims to extend this research by investigating GLUT expression in diabetic mouse models using both qPCR and immunochemistry. We aim to determine what regulates GLUT expression in sympathetic neurons and how expression may be affected in hyperglycaemic conditions.
Prerequisite: 1 term completed at McGill + CGPA of 3.0 or higher; or permission of instructor.
Grading scheme (The final report must be worth at least 50% of final grade): The final grade will be based on an evaluation of laboratory performance (50%) and a final written report (50%) by the supervisor.
Project status: This project is taken. The professor has no more '396' projects this term.
Ethics, safety, and training: Supervisors are responsible for the ethics and safety compliance of undergraduate students. This project involves: Animal subjects; Handling chemicals.