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'Assessing intestinal fibrosis in a mouse infection model' - MIMM 397 Undergraduate Research Project Application Form

INSTRUCTIONS - PROFESSORS: Please print and review this form. Complete or correct the sections, as applicable, from "Supervisor's Name" to "Ethics, safety, and training". Please sign and date near the bottom ("Supervisor's signature").

INSTRUCTIONS - STUDENTS: You may receive this form by email, or you may download it after it has been posted here. Either way, print and review this form. Complete or correct the sections, from "Student's Name" to "Student's Level", and sign ("Student signature"). Ask your supervisor to sign her/his section near the bottom. Take it to the department* corresponding to the course number in Section A; this may or may not be your own department. (* EXCEPTIONS: For NSCI 396 and COGS 396, please bring it to the Interdisciplinary Programs Adviser in Dawson Hall.) Do not register for a '396' course on Minerva until you receive departmental permission. Have a discussion with your supervisor about time/work expectations, keeping in mind that this is a 3-credit course (roughly, 10 hours per week for 12 weeks). Remember that a '396' course is an elective.

INSTRUCTIONS - DEPARTMENTS: After the unit chair/director/designate approves (or not) this project, please notify student. If approved, please give student permission to register on Minerva, and send a copy of this form (with signatures) to the Office for Undergraduate Research in Science (either fax, or internal mail to Dawson Hall 408-A, or PDF scan + email).

QUESTIONS OR FEEDBACK? Contact the Office for Undergraduate Research in Science.


Supervisor's Name: Samantha Gruenheid

Supervisor's Email: samantha [dot] gruenheid [at] mcgill [dot] ca

Supervisor's Phone: 514-398-2138

Supervisor's Website: www.mcgill.ca/complextraits/scientists/samantha-gruenheid

Supervisor's department: Microbiology and Immunology

Course number: MIMM 397 (Immunology)

Term: Winter 2013-2014

Project start date: Monday, January 6, 2014

Project end date: Friday, April 11, 2014

Project title: Assessing intestinal fibrosis in a mouse infection model

Project description (50-100 words suggested): Our lab has identified a specific mouse strain which is highly susceptible to infection with the intestinal pathogen Citrobacter rodentium. This leads to rapid mortality following infection with virulent C. rodentium strains. In further characterizing this model, we have found that when these same highly susceptible mice are infected with an attenuated pathogen (one that is harmless in normal mice), they develop a striking thickening of the cecum and proximal large intestine. We hypothesize that this is due to the development of intestinal fibrosis. The student will test this hypothesis by assaying tissues from infected and control mice for collagen deposition (a hallmark of fibrosis), using the Sircol collagen assay.

Prerequisite: 1 term completed at McGill + CGPA of 3.0 or higher; or permission of instructor.

Grading scheme (The final report must be worth at least 50% of final grade): Final grade shall be based on laboratory performance as evaluated by the research supervisor (50%) and the final written research report (minimum 10 pages) graded by the supervisor and the course coordinator or the coordinator's delegate (50%).

Other project information: The student will not work directly with live animals, only with tissues.

Project status: This project is taken. The professor has no more '396' projects this term.

How students can apply / Next steps: After all parts of this application form are completed, and the hard copy is signed by the professor and the student, bring this application form and your unofficial transcript to Prof. Gregory Marczynski during office hours, who will review/approve as the course coordinator for MIMM 396 (Microbiology) or MIMM 397 (Immunology).

Ethics, safety, and training: Supervisors are responsible for the ethics and safety compliance of undergraduate students. This project involves: Animal subjects; Biohazardous substances.

Student's Name:


Student's McGill ID:


Student's McGill Email:


Student's Phone:


Student's Program:


Student's Level (U0 / U1 / U2 / U3):


Student's signature - I certify that this course is with a different supervisor and on a different topic than any previous '396' course I have taken. I have not applied for another '396' course in this term:


Supervisor's signature - I give my permission for the student identified above to register for this project under my supervision:


Date:


Unit chair/director/designate's name:


Unit chair/director/designate's signature - I certify that this project conforms to departmental requirements for 396 courses:


Date: