'Effect of low dose methotrexate on human hematopoietic stem and progenitor cells' - MIMM 397 Undergraduate Research Project Application Form

INSTRUCTIONS - PROFESSORS: Please print and review this form. Complete or correct the sections, as applicable, from "Supervisor's Name" to "Ethics, safety, and training". Please sign and date near the bottom ("Supervisor's signature").

INSTRUCTIONS - STUDENTS: You may receive this form by email, or you may download it after it has been posted here. Either way, print and review this form. Complete or correct the sections, from "Student's Name" to "Student's Level", and sign ("Student signature"). Ask your supervisor to sign her/his section near the bottom. Take it to the department* corresponding to the course number in Section A; this may or may not be your own department. (* EXCEPTIONS: For NSCI 396 and COGS 396, please bring it to the Interdisciplinary Programs Adviser in Dawson Hall.) Do not register for a '396' course on Minerva until you receive departmental permission. Have a discussion with your supervisor about time/work expectations, keeping in mind that this is a 3-credit course (roughly, 10 hours per week for 12 weeks). Remember that a '396' course is an elective.

INSTRUCTIONS - DEPARTMENTS: After the unit chair/director/designate approves (or not) this project, please notify student. If approved, please give student permission to register on Minerva, and send a copy of this form (with signatures) to the Office for Undergraduate Research in Science (either fax, or internal mail to Dawson Hall 408-A, or PDF scan + email).

QUESTIONS OR FEEDBACK? Contact the Office for Undergraduate Research in Science.

Supervisor's Name: Ines Colmegna

Supervisor's Email: ines [dot] colmegna [at] mcgill [dot] ca

Supervisor's Phone: 514-602-6679

Supervisor's departments: Microbiology and Immunology; Medicine

Course number: MIMM 397 (Immunology)

Term: Winter 2013-2014

Project start date: Monday, January 7, 2014

Project end date: Friday, April 11, 2014

Project title: Effect of low dose methotrexate on human hematopoietic stem and progenitor cells

Project description (50-100 words suggested): This project will evaluate the effect of methotrexate (MTX), the most commonly used drug modifier of the activity of rheumatic diseases (DMARD) in the treatment of rheumatoid arthritis, on a very specific group of cells: hematopoietic progenitors and stem cells (HSPC) that are responsible for the generation of all the mature cells of the immune system. HSPC that normally circulate in the blood reflect the function of those in the bone marrow. We have shown that HSPC from RA patients have a defect in their function. Importantly we also observed that in those patients treated with methotrexate, the function of HSPC is partially restored.

This project will define: 1- What is the effect of MTX on the function of HSPC; 2- What are potential mechanisms involved in the beneficial effect of MTX on RA-HSPC.

Prerequisite: 1 term completed at McGill + CGPA of 3.0 or higher; or permission of instructor.

Grading scheme (The final report must be worth at least 50% of final grade): Final grade shall be based on laboratory performance as evaluated by the research supervisor (50%) and the final written research report (minimum 10 pages) graded by the supervisor and the course coordinator or the coordinator's delegate (50%).

Other project information: Specific objectives have been discussed with the student (literature review, experimental design-performance and interpretation, integration of new data to existing information). The evaluation will be based on the accomplishment of these points.

Project status: This project is taken. The professor has no more '396' projects this term.

Ethics, safety, and training: Supervisors are responsible for the ethics and safety compliance of undergraduate students. This project involves: Human subjects.

Student's Name:

Student's McGill ID:

Student's McGill Email:

Student's Phone:

Student's Program:

Student's Level (U0 / U1 / U2 / U3):

Student's signature - I certify that this course is with a different supervisor and on a different topic than any previous '396' course I have taken. I have not applied for another '396' course in this term:

Supervisor's signature - I give my permission for the student identified above to register for this project under my supervision:


Unit chair/director/designate's name:

Unit chair/director/designate's signature - I certify that this project conforms to departmental requirements for 396 courses: