'Investigate the role of NLRP7 in the genetic susceptibility to sporadic moles' - HGEN 396 Undergraduate Research Project Application Form

INSTRUCTIONS - PROFESSORS: Please print and review this form. Complete or correct the sections, as applicable, from "Supervisor's Name" to "Ethics, safety, and training". Please sign and date near the bottom ("Supervisor's signature").

INSTRUCTIONS - STUDENTS: You may receive this form by email, or you may simply print this webpage. Either way, print and review this form. Complete or correct the sections, from "Student's Name" to "Student's Level", and sign ("Student signature"). Ask your supervisor to sign her/his section near the bottom. Take it to the department* corresponding to the course number in Section A; this may or may not be your own department. (* EXCEPTIONS: For NSCI 396 and COGS 396, please bring it to the Interdisciplinary Programs Adviser in Dawson Hall.) Do not register for a '396' course on Minerva until you receive departmental permission. Have a discussion with your supervisor about time/work expectations, keeping in mind that this is a 3-credit course (roughly, 10 hours per week for 12 weeks). Remember that a '396' course is an elective.

INSTRUCTIONS - DEPARTMENTS: After the unit chair/director/designate approves (or not) this project, please notify student. If approved, please give student permission to register on Minerva, and send a copy of this form (with signatures) to the Office for Undergraduate Research in Science (either fax, or internal mail to Dawson Hall 408-A, or PDF scan + email).

QUESTIONS OR FEEDBACK? Contact the Office for Undergraduate Research in Science.

Supervisor's Name: Rima Slim

Supervisor's Email: rima.slim [at] muhc.mcgill.ca

Supervisor's Phone:

Supervisor's Website: http://slimlab.mcgill.ca/

Supervisor's department: Human Genetics

Course number: HGEN 396 (Human Genetics)

Term: Winter 2013-2014

Project start date: Monday, January 6, 2014

Project end date: Friday, April 11, 2014

Project title: Investigate the role of NLRP7 in the genetic susceptibility to sporadic moles

Project description (50-100 words suggested): A hydatidiform mole is a human pregnancy but with no embryo. Its paradoxical nature has fascinated and puzzled scientists in all civilizations. There are several forms of molar pregnancies. The common form is sporadic and not recurrent. It occurs in 1 in every 600 pregnancies in western societies. Our group identified a causative gene, NLRP7, for a Mendelian form of this condition. Previous work from our group and others indicate that women heterozygous for some mutations are at increased risk for moles and for various other forms of reproductive wastage. The project of the student aims at sequencing the 11 coding exons of NLRP7 in 10 to 20 patients with sporadic moles. The student will learn how to perform PCR, analyze DNA sequences using appropriate software, and annotate them according to official nomenclature. The student will learn to perform his/her work with a Ph.D. trainee or a research assistant and then apply what he/she learned to his/her project. Patients’ materials are ready and the project is well mastered in our laboratory. The project is a good opportunity for students to learn basic molecular genetic methods and contribute to an ongoing project in our laboratory.

Prerequisite: 1 term completed at McGill + CGPA of 3.0 or higher; or permission of instructor.

Grading scheme (The final report must be worth at least 50% of final grade): Final grade shall be based on an evaluation of laboratory (or equivalent) performance (40%), a final written report (50%), and an oral presentation (10%) by the supervisor. Details of the evaluation scheme will be provided by HGEN to supervisors and applicants.

Other project information: Prefer students in U3

Project status: This project is open to applicant.

How students can apply / Next steps: After all of the parts of this application forms are completed and the hard copy is signed by the professor and the student, bring the application form and a copy of your unofficial transcript to the Department of Human Genetics (to the attention of Dr. Patricia N. Tonin, Stewart Biology Building N5.13) during office hours.

Ethics, safety, and training: Supervisors are responsible for the ethics and safety compliance of undergraduate students. This project involves NEITHER animal subjects, nor human subjects, nor biohazardous substances, nor radioactive materials, nor handling chemicals, nor using lasers.

Student's Name:

Student's McGill ID:

Student's McGill Email:

Student's Phone:

Student's Program:

Student's Level (U0 / U1 / U2 / U3):

Student's signature - I certify that this course is with a different supervisor and on a different topic than any previous '396' course I have taken. I have not applied for another '396' course in this term:

Supervisor's signature - I give my permission for the student identified above to register for this project under my supervision:


Unit chair/director/designate's name:

Unit chair/director/designate's signature - I certify that this project conforms to departmental requirements for 396 courses: