Transgenerational epigenetic effects in carriers of chromosomal translocations - HGEN 396 Undergraduate Research Project Application Form
INSTRUCTIONS - PROFESSORS: Please print and review this form. Complete or correct the sections, as applicable, from "Supervisor's Name" to "Ethics, safety, and training". Please sign and date near the bottom ("Supervisor's signature").
INSTRUCTIONS - STUDENTS: You may receive this form by email, or you may download it after it has been posted here. Either way, print and review this form. Complete or correct the sections, from "Student's Name" to "Student's Level", and sign ("Student signature"). Ask your supervisor to sign her/his section near the bottom. Take it to the department* corresponding to the course number in Section A; this may or may not be your own department. (* EXCEPTIONS: For NSCI 396 and COGS 396, please bring it to the Interdisciplinary Programs Adviser in Dawson Hall.) Do not register for a '396' course on Minerva until you receive departmental permission. Have a discussion with your supervisor about time/work expectations, keeping in mind that this is a 3-credit course (roughly, 10 hours per week for 12 weeks). Remember that a '396' course is an elective.
INSTRUCTIONS - DEPARTMENTS: After the unit chair/director/designate approves (or not) this project, please notify student. If approved, please give student permission to register on Minerva, and send a copy of this form (with signatures) to the Office for Undergraduate Research in Science (either fax, or internal mail to Dawson Hall 408-A, or PDF scan + email).
QUESTIONS OR FEEDBACK? Contact the Office for Undergraduate Research in Science.
Supervisor's Name: Anna Naumova
Supervisor's Email: anna [dot] naoumova [at] mcgill [dot] ca
Supervisor's Phone: 8888-35906
Supervisor's department: Human Genetics
Course number: HGEN 396 (Human Genetics)
Term: Winter 2013-2014
Project start date: Monday, January 6, 2014
Project end date: Friday, April 11, 2014
Project title: Transgenerational epigenetic effects in carriers of chromosomal translocations
Project description (50-100 words suggested): During prophase I of meiosis homologous chromosomes pair, synapse and recombine. However, chromosomal rearrangements interfere with chromosomal synapsis. The result of failure to synapse is that unsynapsed regions are silenced by epigenetic mechanisms. This phenomenon is termed meiotic silencing. The question that my laboratory is interested in is if the epigenetic marks of meiotic silencing persist through gametogenesis and are transmitted to embryos causing gene silencing in embryos and abnormal development. The independent study research project will require the student to conduct RNA fluorescent in situ hybridization (RNA FISH) on mouse gametes and preimplantation embryos to identify regions that have lost gene expression as a result of meiotic silencing.
Prerequisite: 1 term completed at McGill + CGPA of 3.0 or higher; or permission of instructor.
Grading scheme (The final report must be worth at least 50% of final grade): Final grade shall be based on an evaluation of laboratory (or equivalent) performance (40%), a final written report (50%), and an oral presentation (10%) by the supervisor. Details of the evaluation scheme will be provided by HGEN to supervisors and applicants.
Other project information: The student should have a good knowledge of basic chemistry, genetics, and molecular biology, manual dexterity and enthusiasm for research. The project will require mouse handling.
Project status: This project is taken; however students may contact the professor to discuss other possible '396' projects this term.
How students can apply / Next steps: For HGEN: After all of the parts of this application forms are completed and the hard copy is signed by the professor and the student, bring the application form and a copy of your unofficial transcript to the Department of Human Genetics (to the attention of Dr. Patricia N. Tonin, Stewart Biology Building N5.13) during office hours.
Ethics, safety, and training: Supervisors are responsible for the ethics and safety compliance of undergraduate students. This project involves: Animal subjects; Handling chemicals.