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'Role of CNVs in Radiation Treatment of Prostate Cancer' - HGEN 396 Undergraduate Research Project Application Form

INSTRUCTIONS - PROFESSORS: Please print and review this form. Complete or correct the sections, as applicable, from "Supervisor's Name" to "Ethics, safety, and training". Please sign and date near the bottom ("Supervisor's signature").

INSTRUCTIONS - STUDENTS: You may receive this form by email, or you may download it after it has been posted here. Either way, print and review this form. Complete or correct the sections, from "Student's Name" to "Student's Level", and sign ("Student signature"). Ask your supervisor to sign her/his section near the bottom. Take it to the department* corresponding to the course number in Section A; this may or may not be your own department. (* EXCEPTIONS: For NSCI 396 and COGS 396, please bring it to the Interdisciplinary Programs Adviser in Dawson Hall.) Do not register for a '396' course on Minerva until you receive departmental permission. Have a discussion with your supervisor about time/work expectations, keeping in mind that this is a 3-credit course (roughly, 10 hours per week for 12 weeks). Remember that a '396' course is an elective.

INSTRUCTIONS - DEPARTMENTS: After the unit chair/director/designate approves (or not) this project, please notify student. If approved, please give student permission to register on Minerva, and send a copy of this form (with signatures) to the Office for Undergraduate Research in Science (either fax, or internal mail to Dawson Hall 408-A, or PDF scan + email).

QUESTIONS OR FEEDBACK? Contact the Office for Undergraduate Research in Science.

Supervisors' Names: Issam El Naqa, Colin Crist

Supervisor's Email: issam [dot] elnaqa [at] mcgill [dot] ca

Supervisor's Phone: 514-934-1934 ext. 45302, 514-340-8222 ext 8541

Supervisor's Website:

Supervisors' departmentd: Human Genetics; Oncology

Course number: HGEN 396 (Human Genetics)

Term: Winter 2013-2014

Project start date: January 7, 2014

Project end date: May 1, 2014

Project title: Role of CNVs in Radiation Treatment of Prostate Cancer

Project description (50-100 words suggested): Quality of life for patients with prostate cancer undergoing radiation therapy (RT) is compromised by the need for aggressive treatment regimes to achieve better tumour control. However, radiation-induced normal tissue toxicities constitute a major complication risk that negatively impact the quality of life of these patients and derail application of promising hypofractionation (HRT) regimens.  Variation in RT sensitivity is known to be an inherited genetic trait. Copy number variants (CNVs) are less numerous than SNPs but they  affect larger portions of the genome and are frequently associated with inflammatory diseases. Using state-of-the art molecular biology techniques and bioinformatics tools, we will investigate the role of CNVs and their ability to explain RT sensitivity compared with known SNPs and dose-volume metrics in favorable risk prostate cancer patients who received HRT.

Prerequisite: 1 term completed at McGill + CGPA of 3.0 or higher; or permission of instructor.

Grading scheme (The final report must be worth at least 50% of final grade): 50% Report; 40% Lab performance; 10% Oral Presentation

Project status: This project is taken. The professor has no more '396' projects this term.

Ethics, safety, and training: Supervisors are responsible for the ethics and safety compliance of undergraduate students. This project involves: Human subjects; Biohazardous substances.

Student's Name:

Student's McGill ID:

Student's McGill Email:

Student's Phone:

Student's Program:

Student's Level (U0 / U1 / U2 / U3):

Student's signature - I certify that this course is with a different supervisor and on a different topic than any previous '396' course I have taken. I have not applied for another '396' course in this term:

Supervisor's signature - I give my permission for the student identified above to register for this project under my supervision:


Unit chair/director/designate's name:

Unit chair/director/designate's signature - I certify that this project conforms to departmental requirements for 396 courses: