INSTRUCTIONS - PROFESSORS: Please print and review this form. Complete or correct the sections, as applicable, from "Supervisor's Name" to "Ethics, safety, and training". Please sign and date near the bottom ("Supervisor's signature").
INSTRUCTIONS - STUDENTS: You may receive this form by email, or you may download it after it has been posted here. Either way, print and review this form. Complete or correct the sections, from "Student's Name" to "Student's Level", and sign ("Student signature"). Ask your supervisor to sign her/his section near the bottom. Take it to the department* corresponding to the course number in Section A; this may or may not be your own department. (* EXCEPTIONS: For NSCI 396 and COGS 396, please bring it to the Interdisciplinary Programs Adviser in Dawson Hall.) Do not register for a '396' course on Minerva until you receive departmental permission. Have a discussion with your supervisor about time/work expectations, keeping in mind that this is a 3-credit course (roughly, 10 hours per week for 12 weeks). Remember that a '396' course is an elective.
INSTRUCTIONS - DEPARTMENTS: After the unit chair/director/designate approves (or not) this project, please notify student. If approved, please give student permission to register on Minerva, and send a copy of this form (with signatures) to the Office for Undergraduate Research in Science (either fax, or internal mail to Dawson Hall 408-A, or PDF scan + email).
QUESTIONS OR FEEDBACK? Contact the Office for Undergraduate Research in Science.
Supervisor's Name: Youla S. Tsantrizos
Supervisor's Email: youla [dot] tsantrizos [at] mcgill [dot] ca
Supervisor's Phone: 398-3638
Supervisor's department: Chemistry
Course number: CHEM 396 (Chemistry)
Term: Winter 2013-2014
Project start date: Monday, January 6, 2014
Project end date: Friday, April 11, 2014
Project title: ZMPSTE24 inhibitors as senescence agonists for cancer therapy
Project description (50-100 words suggested): Cellular senescence is a permanent cell cycle arrest that halts oncogenesis and activate efficient anti tumor immune responses. The goal of our research is to identify senescence agonists that are inhibitors of the enzyme ZMPSTE24. One advantage of triggering senescence versus cell death in patients is the possibility that senescent cells organize antitumor immune responses, which has been so far experimentally documented in mouse models. In other words, a senescent agonist can in principle turns a tumor into a tumor vaccine.
Prerequisite: 1 term completed at McGill + CGPA of 3.0 or higher; or permission of instructor.
Grading scheme (The final report must be worth at least 50% of final grade): 25% group presentations (a minimum of one), 25% laboratory performance, 50% final written report
Project status: This project is taken. The professor has no more '396' projects this term.
Ethics, safety, and training: Supervisors are responsible for the ethics and safety compliance of undergraduate students. This project involves handling chemicals.