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'Characterizing the Poxvirus PACR protein as an oncolytic agent' - BIOC 396 Undergraduate Research Project Application Form

INSTRUCTIONS - PROFESSORS: Please print and review this form. Complete or correct the sections, as applicable, from "Supervisor's Name" to "Ethics, safety, and training". Please sign and date near the bottom ("Supervisor's signature").

INSTRUCTIONS - STUDENTS: You may receive this form by email, or you may download it after it has been posted here. Either way, print and review this form. Complete or correct the sections, from "Student's Name" to "Student's Level", and sign ("Student signature"). Ask your supervisor to sign her/his section near the bottom. Take it to the department* corresponding to the course number in Section A; this may or may not be your own department. (* EXCEPTIONS: For NSCI 396 and COGS 396, please bring it to the Interdisciplinary Programs Adviser in Dawson Hall.) Do not register for a '396' course on Minerva until you receive departmental permission. Have a discussion with your supervisor about time/work expectations, keeping in mind that this is a 3-credit course (roughly, 10 hours per week for 12 weeks). Remember that a '396' course is an elective.

INSTRUCTIONS - DEPARTMENTS: After the unit chair/director/designate approves (or not) this project, please notify student. If approved, please give student permission to register on Minerva, and send a copy of this form (with signatures) to the Office for Undergraduate Research in Science (either fax, or internal mail to Dawson Hall 408-A, or PDF scan + email).

QUESTIONS OR FEEDBACK? Contact the Office for Undergraduate Research in Science.

Supervisor's Name: Jose Teodoro

Supervisor's Email: jose [dot] teodoro [at] mcgill [dot] ca

Supervisor's Phone: 3273

Supervisor's Website: teodorolab.mcgill.ca

Supervisor's department: Biochemistry

Course number: BIOC 396 (Biochemistry)

Term: Winter 2013-2014

Project start date: Monday, January 6, 2014

Project end date: Friday, April 11, 2014

Project title: Characterizing the Poxvirus PACR protein as an oncolytic agent

Project description (50-100 words suggested): This project will study the (Poxvirus Anaphase promoting Complex Regulator) PACR is a protein encoded by some types of poxvirus that encodes a mimetic of the APC subunit APC11. APC11 is a ubiquitin ligase that is required for proper cell cycle progression. PACR displaces APC11 from the complex and directly inhibits the activity of the APC holoenzyme. We have observed that other viral inhibitors of the APC can have powerful oncolytic properties. In the current project the student will evaluate the activity of PACR as an oncolyitc agent by expressing the protein in a panel of tumor cell lines and analyzing effects such as cell cycle arrest, cell proliferation and apoptosis.

Prerequisite: 1 term completed at McGill + CGPA of 3.0 or higher; or permission of instructor.

Grading scheme (The final report must be worth at least 50% of final grade): Final report 50%, Overall lab performance 50%

Project status: This project is taken. The professor has no more '396' projects this term.

How students can apply / Next steps:

Ethics, safety, and training: Supervisors are responsible for the ethics and safety compliance of undergraduate students. This project involves: Biohazardous substances; Handling chemicals.

Student's Name:

Student's McGill ID:

Student's McGill Email:

Student's Phone:

Student's Program:

Student's Level (U0 / U1 / U2 / U3):

Student's signature - I certify that this course is with a different supervisor and on a different topic than any previous '396' course I have taken. I have not applied for another '396' course in this term:

Supervisor's signature - I give my permission for the student identified above to register for this project under my supervision:


Unit chair/director/designate's name:

Unit chair/director/designate's signature - I certify that this project conforms to departmental requirements for 396 courses: