INSTRUCTIONS - PROFESSORS: Please print and review this form. Complete or correct the sections, as applicable, from "Supervisor's Name" to "Ethics, safety, and training". Please sign and date near the bottom ("Supervisor's signature").
INSTRUCTIONS - STUDENTS: You may receive this form by email, or you may download it after it has been posted here. Either way, print and review this form. Complete or correct the sections, from "Student's Name" to "Student's Level", and sign ("Student signature"). Ask your supervisor to sign her/his section near the bottom. Take it to the department* corresponding to the course number in Section A; this may or may not be your own department. (* EXCEPTIONS: For NSCI 396 and COGS 396, please bring it to the Interdisciplinary Programs Adviser in Dawson Hall.) Do not register for a '396' course on Minerva until you receive departmental permission. Have a discussion with your supervisor about time/work expectations, keeping in mind that this is a 3-credit course (roughly, 10 hours per week for 12 weeks). Remember that a '396' course is an elective.
INSTRUCTIONS - DEPARTMENTS: After the unit chair/director/designate approves (or not) this project, please notify student. If approved, please give student permission to register on Minerva, and send a copy of this form (with signatures) to the Office for Undergraduate Research in Science (either fax, or internal mail to Dawson Hall 408-A, or PDF scan + email).
QUESTIONS OR FEEDBACK? Contact the Office for Undergraduate Research in Science.
Supervisor's Name: Jose Teodoro
Supervisor's Email: jose [dot] teodoro [at] mcgill [dot] ca
Supervisor's Phone: 3273
Supervisor's Website: teodorolab.mcgill.ca
Supervisor's department: Biochemistry
Course number: BIOC 396 (Biochemistry)
Term: Winter 2013-2014
Project start date: Monday, January 6, 2014
Project end date: Friday, April 11, 2014
Project title: Characterizing the Poxvirus PACR protein as an oncolytic agent
Project description (50-100 words suggested): This project will study the (Poxvirus Anaphase promoting Complex Regulator) PACR is a protein encoded by some types of poxvirus that encodes a mimetic of the APC subunit APC11. APC11 is a ubiquitin ligase that is required for proper cell cycle progression. PACR displaces APC11 from the complex and directly inhibits the activity of the APC holoenzyme. We have observed that other viral inhibitors of the APC can have powerful oncolytic properties. In the current project the student will evaluate the activity of PACR as an oncolyitc agent by expressing the protein in a panel of tumor cell lines and analyzing effects such as cell cycle arrest, cell proliferation and apoptosis.
Prerequisite: 1 term completed at McGill + CGPA of 3.0 or higher; or permission of instructor.
Grading scheme (The final report must be worth at least 50% of final grade): Final report 50%, Overall lab performance 50%
Project status: This project is taken. The professor has no more '396' projects this term.
How students can apply / Next steps:
Ethics, safety, and training: Supervisors are responsible for the ethics and safety compliance of undergraduate students. This project involves: Biohazardous substances; Handling chemicals.