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Studying the regulating of regulation of translation of apoptotic factors by 4EHP - BIOC 396 Undergraduate Research Project Application Form

INSTRUCTIONS - PROFESSORS: Please print and review this form. Complete or correct the sections, as applicable, from "Supervisor's Name" to "Ethics, safety, and training". Please sign and date near the bottom ("Supervisor's signature").

INSTRUCTIONS - STUDENTS: You may receive this form by email, or you may download it after it has been posted here. Either way, print and review this form. Complete or correct the sections, from "Student's Name" to "Student's Level", and sign ("Student signature"). Ask your supervisor to sign her/his section near the bottom. Take it to the department* corresponding to the course number in Section A; this may or may not be your own department. (* EXCEPTIONS: For NSCI 396 and COGS 396, please bring it to the Interdisciplinary Programs Adviser in Dawson Hall.) Do not register for a '396' course on Minerva until you receive departmental permission. Have a discussion with your supervisor about time/work expectations, keeping in mind that this is a 3-credit course (roughly, 10 hours per week for 12 weeks). Remember that a '396' course is an elective.

INSTRUCTIONS - DEPARTMENTS: After the unit chair/director/designate approves (or not) this project, please notify student. If approved, please give student permission to register on Minerva, and send a copy of this form (with signatures) to the Office for Undergraduate Research in Science (either fax, or internal mail to Dawson Hall 408-A, or PDF scan + email).

QUESTIONS OR FEEDBACK? Contact the Office for Undergraduate Research in Science.


Supervisor's Name: Nahum Sonenberg

Supervisor's Email: nahum [dot] sonenberg [at] mcgill [dot] ca

Supervisor's Phone: 514-398-7274

Supervisor's Website:

Supervisor's department: Biochemistry

Course number: BIOC 396 (Biochemistry)

Term: Winter 2013-2014

Project start date: Monday, January 20, 2014

Project end date: Friday, April 11, 2014

Project title: Studying the regulating of regulation of translation of apoptotic factors by 4EHP

Project description (50-100 words suggested): Eukaryotic translation initiation factor 4E homologous protein is a translation factor whose absence induces apoptosis and reduces cell growth rate. To find out the mechanism underlying this phenotype, we performed a genome-wide ribosome profiling assay. We have found a number of genes that are regulated by 4EHP at the translational level, among which are some prominent pro-apoptotic markers. The purpose of this project is to firstly validate these findings. Then, we would like to figure out how 4EHP regulates these targets and, if by depletion of those targets, we can rescue the phenotype of 4EHP knockdown.

Prerequisite: 1 term completed at McGill + CGPA of 3.0 or higher; or permission of instructor.

Grading scheme (The final report must be worth at least 50% of final grade): Final grade 50% lab work and 50% final report.

Other project information: Eukaryotic translation initiation factor 4E homologous protein is a translation factor whose absence induces apoptosis and reduces cell growth rate. To find out the mechanism underlying this phenotype, we performed a genome-wide ribosome profiling assay. We have found a number of genes that are regulated by 4EHP at the translational level, among which are some prominent pro-apoptotic markers. The purpose of this project is to firstly validate these findings. Then, we would like to figure out how 4EHP regulates these targets and, if by depletion of those targets, we can rescue the phenotype of the 4EHP knockdown.

Project status: This project is taken. The professor has no more '396' projects this term.

Ethics, safety, and training: Supervisors are responsible for the ethics and safety compliance of undergraduate students. This project involves Biohazardous substances.

Student's Name:


Student's McGill ID:


Student's McGill Email:


Student's Phone:


Student's Program:


Student's Level (U0 / U1 / U2 / U3):


Student's signature - I certify that this course is with a different supervisor and on a different topic than any previous '396' course I have taken. I have not applied for another '396' course in this term:


Supervisor's signature - I give my permission for the student identified above to register for this project under my supervision:


Date:


Unit chair/director/designate's name:


Unit chair/director/designate's signature - I certify that this project conforms to departmental requirements for 396 courses:


Date: