Quantitative assessment of neuroanatomical correlates of pathology in Alzheimer's Disease mouse models - ANAT 396 Undergraduate Research Project Application Form
INSTRUCTIONS - PROFESSORS: Please print and review this form. Complete or correct the sections, as applicable, from "Supervisor's Name" to "Ethics, safety, and training". Please sign and date near the bottom ("Supervisor's signature").
INSTRUCTIONS - STUDENTS: You may receive this form by email, or you may download it after it has been posted here. Either way, print and review this form. Complete or correct the sections, from "Student's Name" to "Student's Level", and sign ("Student signature"). Ask your supervisor to sign her/his section near the bottom. Take it to the department* corresponding to the course number in Section A; this may or may not be your own department. (* EXCEPTIONS: For NSCI 396 and COGS 396, please bring it to the Interdisciplinary Programs Adviser in Dawson Hall.) Do not register for a '396' course on Minerva until you receive departmental permission. Have a discussion with your supervisor about time/work expectations, keeping in mind that this is a 3-credit course (roughly, 10 hours per week for 12 weeks). Remember that a '396' course is an elective.
INSTRUCTIONS - DEPARTMENTS: After the unit chair/director/designate approves (or not) this project, please notify student. If approved, please give student permission to register on Minerva, and send a copy of this form (with signatures) to the Office for Undergraduate Research in Science (either fax, or internal mail to Dawson Hall 408-A, or PDF scan + email).
QUESTIONS OR FEEDBACK? Contact the Office for Undergraduate Research in Science.
Supervisor's Name: Thomas Stroh
Supervisor's Email: thomas [dot] stroh [at] mcgill [dot] ca
Supervisor's Phone: 514-398-2719
Supervisor's department: Anatomy and Cell Biology; Neurology and Neurosurgery
Course number: ANAT 396 (Anatomy and Cell Biology)
Term: Winter 2013-2014
Project start date: Monday, January 6, 2014
Project end date: Friday, April 11, 2014
Project title: Quantitative assessment of neuroanatomical correlates of pathology in Alzheimer's Disease mouse models
Project description (50-100 words suggested): In transgenic mouse models of Alzheimer's disease (AD) we will study the impact of the angiotensin type II receptor subtype AT2 in the brain on the manifestation and progression of AD as measured by the expression pattern the microtubule-associated protein tau and the histoarchitecture and volume of the dorsal hippocampus. To this end, the student will employ standard neuroanatomical techniques such as cryosectioning, cresyl violet staining and immunostaining of frozen sections. The histological parameters of the thus produced samples will be quantitatively analyzed using high-resolving microscopy and unbiased stereology. The student will thus learn key techniques of quantitative neuroanatomy.
Prerequisite: 1 term completed at McGill + CGPA of 3.0 or higher; or permission of instructor.
Grading scheme (The final report must be worth at least 50% of final grade): Final grade shall be based on laboratory performance as evaluated by the research supervisor (50%) and the final written research report (minimum 10 pages) graded by the supervisor and the course coordinator or the coordinator's delegate (50%).
Other project information: The brain tissue is already present in fixed and deep frozen form in the laboratory. For the student conducting the research that means there is no requirement to conduct animal procedures.
Project status: This project is taken. The professor has no more '396' projects this term.
Ethics, safety, and training: Supervisors are responsible for the ethics and safety compliance of undergraduate students. This project involves: Handling chemicals.