Defining the VPS-34 complex that regulates TBC-2 - ANAT 396 Undergraduate Research Project Application Form
INSTRUCTIONS - PROFESSORS: Please print and review this form. Complete or correct the sections, as applicable, from "Supervisor's Name" to "Ethics, safety, and training". Please sign and date near the bottom ("Supervisor's signature").
INSTRUCTIONS - STUDENTS: You may receive this form by email, or you may download it after it has been posted here. Either way, print and review this form. Complete or correct the sections, from "Student's Name" to "Student's Level", and sign ("Student signature"). Ask your supervisor to sign her/his section near the bottom. Take it to the department* corresponding to the course number in Section A; this may or may not be your own department. (* EXCEPTIONS: For NSCI 396 and COGS 396, please bring it to the Interdisciplinary Programs Adviser in Dawson Hall.) Do not register for a '396' course on Minerva until you receive departmental permission. Have a discussion with your supervisor about time/work expectations, keeping in mind that this is a 3-credit course (roughly, 10 hours per week for 12 weeks). Remember that a '396' course is an elective.
INSTRUCTIONS - DEPARTMENTS: After the unit chair/director/designate approves (or not) this project, please notify student. If approved, please give student permission to register on Minerva, and send a copy of this form (with signatures) to the Office for Undergraduate Research in Science (either fax, or internal mail to Dawson Hall 408-A, or PDF scan + email).
QUESTIONS OR FEEDBACK? Contact the Office for Undergraduate Research in Science.
Supervisor's Name: Christian Rocheleau
Supervisor's Email: christian [dot] rocheleau [at] mcgill [dot] ca
Supervisor's Phone: 514-398-3979
Supervisor's Website: www.rocheleaulab.com
Supervisor's department: Anatomy and Cell Biology
Course number: ANAT 396 (Anatomy and Cell Biology)
Term: Winter 2013-2014
Project start date: Monday, January 6, 2014
Project end date: Friday, April 11, 2014
Project title: Defining the VPS-34 complex that regulates TBC-2
Project description (50-100 words suggested): TBC-2 is a RAB-5 GTPase Activating Protein and hence an important regulator of endosome maturation. TBC-2 is recruited to endosome membranes in a VPS-34 dependent manner. VPS-34 can function in several different protein complexes. The aim of this study is to identify which complex components contribute to TBC-2 membrane recruitment. The student will use RNA-mediated interference and C. elegans genetics to test candidate genes for roles in TBC-2 recruitment. In addition to learning techniques in C. elegans culture and genetics, the student will use epifluorescence microscopy to analysis the subcellular localization of TBC-2 and other endosomal proteins.
Prerequisite: 1 term completed at McGill + CGPA of 3.0 or higher; or permission of instructor.
Grading scheme (The final report must be worth at least 50% of final grade): Final grade shall be based on an evaluation of laboratory performance (40%), a final written report of 10 pages double spaced (50%), and an oral presentation (10%) at a lab meeting.
Project status: This project is taken. The professor has no more '396' projects this term.
Ethics, safety, and training: Supervisors are responsible for the ethics and safety compliance of undergraduate students. This project involves: Biohazardous substances.