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'The role of CdGAP in the developing cortex' - ANAT 396 Undergraduate Research Project Application Form

INSTRUCTIONS - PROFESSORS: Please print and review this form. Complete or correct the sections, as applicable, from "Supervisor's Name" to "Ethics, safety, and training". Please sign and date near the bottom ("Supervisor's signature").

INSTRUCTIONS - STUDENTS: You may receive this form by email, or you may download it after it has been posted here. Either way, print and review this form. Complete or correct the sections, from "Student's Name" to "Student's Level", and sign ("Student signature"). Ask your supervisor to sign her/his section near the bottom. Take it to the department* corresponding to the course number in Section A; this may or may not be your own department. (* EXCEPTIONS: For NSCI 396 and COGS 396, please bring it to the Interdisciplinary Programs Adviser in Dawson Hall.) Do not register for a '396' course on Minerva until you receive departmental permission. Have a discussion with your supervisor about time/work expectations, keeping in mind that this is a 3-credit course (roughly, 10 hours per week for 12 weeks). Remember that a '396' course is an elective.

INSTRUCTIONS - DEPARTMENTS: After the unit chair/director/designate approves (or not) this project, please notify student. If approved, please give student permission to register on Minerva, and send a copy of this form (with signatures) to the Office for Undergraduate Research in Science (either fax, or internal mail to Dawson Hall 408-A, or PDF scan + email).

QUESTIONS OR FEEDBACK? Contact the Office for Undergraduate Research in Science.

Supervisor's Name: Nathalie Lamarche-Vane

Supervisor's Email: nathalie [dot] lamarche [at] mcgill [dot] ca

Supervisor's Phone: 1784

Supervisor's Website:

Supervisor's department: Anatomy and Cell Biology

Course number: ANAT 396 (Anatomy and Cell Biology)

Term: Winter 2013-2014

Project start date: January 6, 2014

Project end date: April 1st, 2014

Project title: The role of CdGAP in the developing cortex

Project description (50-100 words suggested): The family of small Rho GTPases is a subfamily of the Ras superfamily of small GTPases, which act as molecular switches and cycle between an active GTP-bound state and an inactive GDP-bound state. Once activated, they regulate a diverse set of cellular processes linked to the remodeling of the cytoskeleton. Rho GTPases are therefore essential regulators of cell motility and dysregulation of their activities can result in different abnormal phenotypes, particularly, tumor progression and metastasis. Therefore, regulators of Rho GTPases are critical for normal cellular responses and are targets for subversion during oncogenic transformation. CdGAP (Cdc42 GTPase-activating protein) is a GTPase regulator belonging to a novel well-conserved subfamily of RhoGAP proteins, which regulates specifically Rac1 and Cdc42 and modulates numerous cellular processes such as cytoskeleton remodelling and cell migration. More recently, we have demonstrated the implication of CdGAP in the regulation of cell migration, adhesion, and proliferation. Moreover, CdGAP is associated with a rare developmental disease, the Adams-Oliver syndrome. We have generated CdGAP-deficient mice and this project is to characterize the function of CdGAP in the developing cortex. CdGAP is highly expressed in the developing cortex and hippocampus and in this project, dissociated cortical and hippocampal neurons from WT or CdGAP-deficient mice will be analysed by immunofluorescence and defects in axon and/or dendrite formation will be measured.

Prerequisite: 1 term completed at McGill + CGPA of 3.0 or higher; or permission of instructor.

Grading scheme (The final report must be worth at least 50% of final grade): Lab performance 50%; final report 50%.

Project status: This project is taken. The professor has no more '396' projects this term.

How students can apply / Next steps: After all parts of this application form are completed, and the hard copy is signed by the professor and the student, bring this application form and your unofficial transcript to Ms Vittoria Catania during office hours.

Ethics, safety, and training: Supervisors are responsible for the ethics and safety compliance of undergraduate students. This project involves biohazardous substances.

Student's Name:

Student's McGill ID:

Student's McGill Email:

Student's Phone:

Student's Program:

Student's Level (U0 / U1 / U2 / U3):

Student's signature - I certify that this course is with a different supervisor and on a different topic than any previous '396' course I have taken. I have not applied for another '396' course in this term:

Supervisor's signature - I give my permission for the student identified above to register for this project under my supervision:


Unit chair/director/designate's name:

Unit chair/director/designate's signature - I certify that this project conforms to departmental requirements for 396 courses: