'Manipulation of the life cycle of Aspergillus fumigatus: a novel therapeutic strategy' - MIMM 396 Undergraduate Research Project Application Form
INSTRUCTIONS - PROFESSORS: Please print and review this form. Complete or correct the sections, as applicable, from "Supervisor's Name" to "Ethics, safety, and training". Please sign and date near the bottom ("Supervisor's signature").
INSTRUCTIONS - STUDENTS: You may receive this form by email, or you may download it after it has been posted here. Either way, print and review this form. Complete or correct the sections, from "Student's Name" to "Student's Level", and sign ("Student signature"). Ask your supervisor to sign her/his section near the bottom. Take it to the department* corresponding to the course number in Section A; this may or may not be your own department. (* EXCEPTIONS: For NSCI 396 and COGS 396, please bring it to the Interdisciplinary Programs Adviser in Dawson Hall.) Do not register for a '396' course on Minerva until you receive departmental permission. Have a discussion with your supervisor about time/work expectations, keeping in mind that this is a 3-credit course (roughly, 10 hours per week for 12 weeks). Remember that a '396' course is an elective.
INSTRUCTIONS - DEPARTMENTS: After the unit chair/director/designate approves (or not) this project, please notify student. If approved, please give student permission to register on Minerva, and send a copy of this form (with signatures) to the Office for Undergraduate Research in Science (either fax, or internal mail to Dawson Hall 408-A, or PDF scan + email).
QUESTIONS OR FEEDBACK? Contact the Office for Undergraduate Research in Science.
Supervisor's Name: Donald Sheppard
Supervisor's Email: donald [dot] sheppard [at] mcgill [dot] ca
Supervisor's Phone: 1759
Supervisor's department: Microbiology and Immunology
Course number: MIMM 396 (Microbiology)
Term: Fall 2013-2014
Project start date: Tuesday, September 3, 2013
Project end date: Tuesday, December 3, 2013
Project title: Manipulation of the life cycle of Aspergillus fumigatus: a novel therapeutic strategy
Project description (50-100 words suggested): Aspergillus fumigatus is an ubiquitous fungus that causes an often fatal invasive pneumonia in immunocompromised patients. The success of the fungus is linked to its ability to limit vegetative growth and efficiently sporulate to disperse high numbers of asexual spores in the environment, while switching to vegetative growth in the host. We hypothesize that forcing sporulation during infection will suppress vegetative growth and impair virulence. In this project, the student will focus on studying the link between sporulation and virulence in A. fumigatus through the construction of a mutant strain in which the master regulator of sporulation will be placed under the control of an inducible promotor to force sporulation during infection. The in vitro and in vivo phenotypes of these mutants will be studied for growth defects and morphological changes.
Prerequisite: 1 term completed at McGill + CGPA of 3.0 or higher; or permission of instructor.
Grading scheme (The final report must be worth at least 50% of final grade): The final grade will be based on an evaluation by the supervisor of laboratory performance (50%) and a final written report (50%).
Project status: This project is taken; however students may contact the professor to discuss other possible '396' projects this term.
How students can apply: N/A; this project is filled.
Ethics, safety, and training: Supervisors are responsible for the ethics and safety compliance of undergraduate students. This project involves: Animal subjects; Biohazardous substances.