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'Design and Synthesis of Novel N-BPs' - CHEM 396 Undergraduate Research Project Application Form

INSTRUCTIONS - PROFESSORS: Please print and review this form. Complete or correct the sections, as applicable, from "Supervisor's Name" to "Ethics, safety, and training". Please sign and date near the bottom ("Supervisor's signature").

INSTRUCTIONS - STUDENTS: You may receive this form by email, or you may download it after it has been posted here. Either way, print and review this form. Complete or correct the sections, from "Student's Name" to "Student's Level", and sign ("Student signature"). Ask your supervisor to sign her/his section near the bottom. Take it to the department* corresponding to the course number in Section A; this may or may not be your own department. (* EXCEPTIONS: For NSCI 396 and COGS 396, please bring it to the Interdisciplinary Programs Adviser in Dawson Hall.) Do not register for a '396' course on Minerva until you receive departmental permission. Have a discussion with your supervisor about time/work expectations, keeping in mind that this is a 3-credit course (roughly, 10 hours per week for 12 weeks). Remember that a '396' course is an elective.

INSTRUCTIONS - DEPARTMENTS: After the unit chair/director/designate approves (or not) this project, please notify student. If approved, please give student permission to register on Minerva, and send a copy of this form (with signatures) to the Office for Undergraduate Research in Science (either fax, or internal mail to Dawson Hall 408-A, or PDF scan + email).

QUESTIONS OR FEEDBACK? Contact the Office for Undergraduate Research in Science.

Supervisor's Name: Youla Tsantrizos

Supervisor's Email: youla [dot] tsantrizos [at] mcgill [dot] ca

Supervisor's Phone: (514) 398-3638

Supervisor's Website: http://tsantrizos-group.mcgill.ca

Supervisor's department: Chemistry

Course number: CHEM 396 (Chemistry)

Term: Fall 2013-2014

Project start date: Tuesday, September 3, 2013

Project end date: Tuesday, December 3, 2013

Project title: Design and Synthesis of Novel N-BPs

Project description (50-100 words suggested): It is estimated that more than 250,000 new cases of cancer will be diagnosed in Canada in 2013 (according to the Canadian cancer society) and new molecular tools for the treatment of cancer are desperately needed. Nitrogen-containing bisphosphonates (N-BPs) are clinically validated drugs for the treatment of bone cancer metastasis, which claims the lives of approximately 70% of all breast and prostate cancer patients. N-BPs inhibit the human Farnesyl Pyrophosphate Synthase (hFPPS), an enzyme which is important for cancer proliferation. Currently available N-BPs suffer from poor selectivity and are difficult to administer to patients due to their extremely low oral bioavailability. This CHEM 396 project will involve the design and synthesis of novel N-BPs with improved biopharmaceutical properties to address these issues. In particular we aim to synthesize novel inhibitors for hFPPS based on a spiral indole scaffold that would occupy a larger portion of the enzyme’s active site cavity. The project will involve synthesis and structural characterization of many new compounds, as well as learning about the biochemistry involved in oncogenesis.

Prerequisite: 1 term completed at McGill + CGPA of 3.0 or higher; or permission of instructor.

Grading scheme (The final report must be worth at least 50% of final grade): 25% for lab work; 25% for group participation at meeting and presentations of the research; 50% for final report.

Project status: This project is taken.

Ethics, safety, and training: Supervisors are responsible for the ethics and safety compliance of undergraduate students. This project involves: Biohazardous substances; Handling chemicals

Student's Name:

Student's McGill ID:

Student's McGill Email:

Student's Phone:

Student's Program:

Student's Level (U0 / U1 / U2 / U3):

Student's signature - I certify that this course is with a different supervisor and on a different topic than any previous '396' course I have taken. I have not applied for another '396' course in this term:

Supervisor's signature - I give my permission for the student identified above to register for this project under my supervision:


Unit chair/director/designate's name:

Unit chair/director/designate's signature - I certify that this project conforms to departmental requirements for 396 courses: