INSTRUCTIONS - PROFESSORS: Please print and review this form. Complete or correct the sections, as applicable, from "Supervisor's Name" to "Ethics, safety, and training". Please sign and date near the bottom ("Supervisor's signature").
INSTRUCTIONS - STUDENTS: You may receive this form by email, or you may download it after it has been posted here. Either way, print and review this form. Complete or correct the sections, from "Student's Name" to "Student's Level", and sign ("Student signature"). Ask your supervisor to sign her/his section near the bottom. Take it to the department* corresponding to the course number in Section A; this may or may not be your own department. (* EXCEPTIONS: For NSCI 396 and COGS 396, please bring it to the Interdisciplinary Programs Adviser in Dawson Hall.) Do not register for a '396' course on Minerva until you receive departmental permission. Have a discussion with your supervisor about time/work expectations, keeping in mind that this is a 3-credit course (roughly, 10 hours per week for 12 weeks). Remember that a '396' course is an elective.
INSTRUCTIONS - DEPARTMENTS: After the unit chair/director/designate approves (or not) this project, please notify student. If approved, please give student permission to register on Minerva, and send a copy of this form (with signatures) to the Office for Undergraduate Research in Science (either fax, or internal mail to Dawson Hall 408-A, or PDF scan + email).
QUESTIONS OR FEEDBACK? Contact the Office for Undergraduate Research in Science.
Supervisor's Name: Dr. Morag Park
Supervisor's Email: morag [dot] park [at] mcgill [dot] ca
Supervisor's Phone: 514-398-5749
Supervisor's Website: http://www.mcgill.ca/biochemistry/about-us/department/faculty-members/park
Supervisor's department: Biochemistry
Course number: BIOC 396 (Biochemistry)
Term: Fall 2013-2014
Project start date: Tuesday, September 3, 2013
Project end date: Tuesday, December 3, 2013
Project title: Establishing Mechanisms of Acquired Resistance to Met-inhibitor in Met-addicted Gastric Cancer Cell Lines
Project description (50-100 words suggested): Signaling by the Met hepatocyte growth factor (HGF) receptor tyrosine kinase (RTK), activates several downstream signaling pathways that promote cell migration and invasive growth. As several Met inhibitors are presently in all three phases of clinical trials, and Met signaling is a means of escaping treatment by other targeted small-molecule kinase inhibitors, there exists a great need to determine the mechanisms through which cells may circumvent Met inhibition. The goal is to use genetic and biochemical techniques to identify such resistance mechanisms. This will be essential for developing multi-ponged therapeutic strategies that may prove more efficacious at combatting tumorigenesis.
Prerequisite: 1 term completed at McGill + CGPA of 3.0 or higher; or permission of instructor.
Grading scheme (The final report must be worth at least 50% of final grade): Research report 50%; Laboratory performance 50%
Project status: This project is taken.
How students can apply: Bring a printed copy of this application form and your advising transcript to me during office hours.
Ethics, safety, and training: Supervisors are responsible for the ethics and safety compliance of undergraduate students. This project involves:Biohazardous substances; Handling chemicals.