'Functional study of PKLR mutations and association with malaria resistance' - BIOC 396 Undergraduate Research Project Application Form
INSTRUCTIONS - PROFESSORS: Please print and review this form. Complete or correct the sections, as applicable, from "Supervisor's Name" to "Ethics, safety, and training". Please sign and date near the bottom ("Supervisor's signature").
INSTRUCTIONS - STUDENTS: You may receive this form by email, or you may download it after it has been posted here. Either way, print and review this form. Complete or correct the sections, from "Student's Name" to "Student's Level", and sign ("Student signature"). Ask your supervisor to sign her/his section near the bottom. Take it to the department* corresponding to the course number in Section A; this may or may not be your own department. (* EXCEPTIONS: For NSCI 396 and COGS 396, please bring it to the Interdisciplinary Programs Adviser in Dawson Hall.) Do not register for a '396' course on Minerva until you receive departmental permission. Have a discussion with your supervisor about time/work expectations, keeping in mind that this is a 3-credit course (roughly, 10 hours per week for 12 weeks). Remember that a '396' course is an elective.
INSTRUCTIONS - DEPARTMENTS: After the unit chair/director/designate approves (or not) this project, please notify student. If approved, please give student permission to register on Minerva, and send a copy of this form (with signatures) to the Office for Undergraduate Research in Science (either fax, or internal mail to Dawson Hall 408-A, or PDF scan + email).
QUESTIONS OR FEEDBACK? Contact the Office for Undergraduate Research in Science.
Supervisor's Name: Philippe Gros
Supervisor's Email: philippe [dot] gros [at] mcgill [dot] ca
Supervisor's Phone: 514-398-7291
Supervisor's Website: http://www.mcgill.ca/biochemistry/about-us/department/faculty-members/gros
Supervisor's department: Biochemistry
Course number: BIOC 396 (Biochemistry)
Term: Fall 2013-2014
Project start date: Tuesday, September 3, 2013
Project end date: Tuesday, December 3, 2013
Project title: Functional study of PKLR mutations and association with malaria resistance
Project description (50-100 words suggested): PKLR encodes for the erythrocyte-specific isoform of the pyruvate kinase (PK-R) enzyme. Mutations that alter the functional activity of this enzyme result in PK-deficiency, the most common cause of nonspherocytic hemolytic anemia. Recently, PK-deficiency was associated with resistance to malaria. Several PKLR mutations were identified within two populations living in malaria endemic regions. By examining the effect of these mutations on PK-R activity, we seek to determine whether these mutations have a deleterious effect on enzyme function resulting in PK-deficiency, which may be associated with resistance to malaria.
Prerequisite: 1 term completed at McGill + CGPA of 3.0 or higher; or permission of instructor.
Grading scheme (The final report must be worth at least 50% of final grade): 50% Laboratory performance, 50% Written report
Project status: This project is taken; however students may contact the professor to discuss other possible '396' projects this term.
Ethics, safety, and training: Supervisors are responsible for the ethics and safety compliance of undergraduate students. This project involves handling chemicals.