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'Identification of Staphylococcal Immune Modulatory Ligands Using Transposonomics' - MIMM 397 Undergraduate Research Project Application Form

INSTRUCTIONS - PROFESSORS: Please print and review this form. Complete or correct the sections, as applicable, from "Supervisor's Name" to "Ethics, safety, and training". Please sign and date near the bottom ("Supervisor's signature").

INSTRUCTIONS - STUDENTS: You may receive this form by email, or you may download it after it has been posted here. Either way, print and review this form. Complete or correct the sections, from "Student's Name" to "Student's Level", and sign ("Student signature"). Ask your supervisor to sign her/his section near the bottom. Take it to the department* corresponding to the course number in Section A; this may or may not be your own department. (* EXCEPTIONS: For NSCI 396 and COGS 396, please bring it to the Interdisciplinary Programs Adviser in Dawson Hall.) Do not register for a '396' course on Minerva until you receive departmental permission. Have a discussion with your supervisor about time/work expectations, keeping in mind that this is a 3-credit course (roughly, 10 hours per week for 12 weeks). Remember that a '396' course is an elective.

INSTRUCTIONS - DEPARTMENTS: After the unit chair/director/designate approves (or not) this project, please notify student. If approved, please give student permission to register on Minerva, and send a copy of this form (with signatures) to the Office for Undergraduate Research in Science (either fax, or internal mail to Dawson Hall 408-A, or PDF scan + email).

QUESTIONS OR FEEDBACK? Contact the Office for Undergraduate Research in Science.


Supervisor's Name: Joaquin Madrenas

Supervisor's Email: joaquin [dot] madrenas [at] mcgill [dot] ca

Supervisor's Phone: 514-398-3914

Supervisor's Website:

Supervisor's department: Microbiology and Immunology

Course number: MIMM 397 (Immunology

Term: Summer 2013

Project start date: Monday, May 1, 2013

Project end date: Tuesday, August 30, 2013

Project title: Identification of Staphylococcal Immune Modulatory Ligands Using Transposonomics

Project description: This project will continue on earlier work published by the lab showing that Staphylococcus aureus can downregulate the T cell response to staphylococcal superantigens by inducing IL-10 secretion in a TLR2-dependent mechanism. We hypothesize that S. aureus contains two types of ligands: ones that induce a predominantly a pro-inflammatory response and others that induce an anti-inflammatory response. Using transposonomics, a novel high throughput technique we have developed, we have identified a panel of mutants with enhanced or reduced IL-10-inducing capacity, compared to the parental strain. The project for this student will focus on characterizing the immuno-modulatory profile of several of these mutants. The student will become familiar with basic microbiology techniques, isolating and stimulating human PBMCs, standard tissue culture techniques, and functional ELISA-based assays.

Prerequisite: 1 term completed at McGill + CGPA of 3.0 or higher; or permission of instructor.

Grading scheme (The final report must be worth at least 50% of final grade): Final grade shall be based on laboratory performance as evaluated by the research supervisor (50%) and the final written research report (minimum 10 pages) graded by the supervisor and the course coordinator or the coordinator's delegate (50%).

Project status: This project is taken; however students may contact the professor to discuss other possible '396' projects this term.

How students can apply: For MIMM: After all parts of this application form are completed, and the hard copy is signed by the professor and the student, bring this application form and your unofficial transcript to Prof. Gregory Marczynski during office hours, who will review/approve as the course coordinator for MIMM 396 (Microbiology) or MIMM 397 (Immunology).

Ethics, safety, and training: Supervisors are responsible for the ethics and safety compliance of undergraduate students. This project involves: Human subjects; Biohazardous substances; Handling chemicals.

Student's Name:


Student's McGill ID:


Student's McGill Email:


Student's Phone:


Student's Program:


Student's Level (U0 / U1 / U2 / U3):


Student's signature - I certify that this course is with a different supervisor and on a different topic than any previous '396' course I have taken. I have not applied for another '396' course in this term:


Supervisor's signature - I give my permission for the student identified above to register for this project under my supervision:


Date:


Unit chair/director/designate's name:


Unit chair/director/designate's signature - I certify that this project conforms to departmental requirements for 396 courses:


Date: