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'Somatic copy-number changes in autoimmunity' - HGEN 396 Undergraduate Research Project Application Form

INSTRUCTIONS - PROFESSORS: Please print and review this form. Complete or correct the sections, as applicable, from "Supervisor's Name" to "Ethics, safety, and training". Please sign and date near the bottom ("Supervisor's signature").

INSTRUCTIONS - STUDENTS: You may receive this form by email, or you may download it after it has been posted here. Either way, print and review this form. Complete or correct the sections, from "Student's Name" to "Student's Level", and sign ("Student signature"). Ask your supervisor to sign her/his section near the bottom. Take it to the department* corresponding to the course number in Section A; this may or may not be your own department. (* EXCEPTIONS: For NSCI 396 and COGS 396, please bring it to the Interdisciplinary Programs Adviser in Dawson Hall.) Do not register for a '396' course on Minerva until you receive departmental permission. Have a discussion with your supervisor about time/work expectations, keeping in mind that this is a 3-credit course (roughly, 10 hours per week for 12 weeks). Remember that a '396' course is an elective.

INSTRUCTIONS - DEPARTMENTS: After the unit chair/director/designate approves (or not) this project, please notify student. If approved, please give student permission to register on Minerva, and send a copy of this form (with signatures) to the Office for Undergraduate Research in Science (either fax, or internal mail to Dawson Hall 408-A, or PDF scan + email).

QUESTIONS OR FEEDBACK? Contact the Office for Undergraduate Research in Science.

Supervisor's Name: Constantin Polychronakos

Supervisor's Email: constantin [dot] polychronakos [at] mcgill [dot] ca

Supervisor's Phone: 514-412-4400 ext. 22866

Supervisor's Website: http://muhc.ca/research/researcher/constantin-polychronakos-md

Supervisor's department: Human Genetics

Course number: HGEN 396 (Human Genetics)

Term: Summer 2013

Project start date: Monday, May 6, 2013

Project end date: Friday, August 30 2013

Project title: Somatic copy-number changes in autoimmunity

Project description: T-lymphocyte mediated autoimmunity is due to loss of self-tolerance by lineages of autoreactive T-cells that proliferate extensively, creating a disease-causing mass of cells out of a handful of original cells whose T-cell receptor recognises autoantigen. During this mitotic cascade, somatic mutations can arise creating mosaicism for copy-number alterations. We are currently studying pathogenic lymphocytes from two such diseases, rheumatoid arthritis and type 1 diabetes by high-resolution microarrays. The student will confirm the microarray findings with MLPA. The project also involves separating T-cell subsets by flow sorting or magnetic beads, short-term primary cell cultures and other basic immunological and molecular biology techniques.

Prerequisite: 1 term completed at McGill + CGPA of 3.0 or higher; or permission of instructor.

Grading scheme (The final report must be worth at least 50% of final grade): Final grade shall be based on an evaluation of laboratory (or equivalent) performance (40%), a final written report (50%), and an oral presentation (10%) by the supervisor. Details of the evaluation scheme will be provided by HGEN to supervisors and applicants.

Other project information: Large genetics-immunology lab with three graduate students, two post-docs and five research personnel.

Project status: This project is open to applicant.

How students can apply: Please contact PI e-mail

Ethics, safety, and training: Supervisors are responsible for the ethics and safety compliance of undergraduate students. This project involves: Animal subjects; Human subjects; Handling chemicals.

Student's Name:

Student's McGill ID:

Student's McGill Email:

Student's Phone:

Student's Program:

Student's Level (U0 / U1 / U2 / U3):

Student's signature - I certify that this course is with a different supervisor and on a different topic than any previous '396' course I have taken. I have not applied for another '396' course in this term:

Supervisor's signature - I give my permission for the student identified above to register for this project under my supervision:


Unit chair/director/designate's name:

Unit chair/director/designate's signature - I certify that this project conforms to departmental requirements for 396 courses: