'Association between Carotid Plaque Adipokine levels and Plaque Stability' - BIOC 396 Undergraduate Research Project Application Form
INSTRUCTIONS - PROFESSORS: Please print and review this form. Complete or correct the sections, as applicable, from "Supervisor's Name" to "Ethics, safety, and training". Please sign and date near the bottom ("Supervisor's signature").
INSTRUCTIONS - STUDENTS: You may receive this form by email, or you may download it after it has been posted here. Either way, print and review this form. Complete or correct the sections, from "Student's Name" to "Student's Level", and sign ("Student signature"). Ask your supervisor to sign her/his section near the bottom. Take it to the department* corresponding to the course number in Section A; this may or may not be your own department. (* EXCEPTIONS: For NSCI 396 and COGS 396, please bring it to the Interdisciplinary Programs Adviser in Dawson Hall.) Do not register for a '396' course on Minerva until you receive departmental permission. Have a discussion with your supervisor about time/work expectations, keeping in mind that this is a 3-credit course (roughly, 10 hours per week for 12 weeks). Remember that a '396' course is an elective.
INSTRUCTIONS - DEPARTMENTS: After the unit chair/director/designate approves (or not) this project, please notify student. If approved, please give student permission to register on Minerva, and send a copy of this form (with signatures) to the Office for Undergraduate Research in Science (either fax, or internal mail to Dawson Hall 408-A, or PDF scan + email).
QUESTIONS OR FEEDBACK? Contact the Office for Undergraduate Research in Science.
Supervisor's Name: Jacques Genest
Supervisor's Email: Jacques [dot] genest [at] mcgill [dot] ca
Supervisor's department: Biochemistry
Course number: BIOC 396 (Biochemistry)
Term: Winter 2012-2013
Project start date: Monday, January 7, 2013
Project end date: Tuesday, April 16, 2013
Project title: Association between Carotid Plaque Adipokine levels and Plaque Stability
Project description:Adipokines are signaling proteins secreted mainly by adipose tissue but also inflammatory cells. Adipokines play active roles in both metabolism and inflammation. Resistin and chemerin are two newly identified pro-inflammatory adipokines. However, their role in atherosclerosis is not well defined. The objective of this project is to determine the association between plaque expression of resistin and chemerin and stability of carotid plaques.
cDNA will be reverse transcribed from isolated mRNA from human carotid plaque specimens. Resistin, chemerin, and chemerin receptor will be measured by qPCR, immunohistochemistry, and western blotting. To date we have recruited 160 patients. Stability of carotid plaques has been previously assessed by two vascular pathologists. Statistical analyses will be performed to evaluate the association between plaque adipokine expression and plaque stability.
Prerequisite: 1 term completed at McGill + CGPA of 3.0 or higher; or permission of instructor.
Grading scheme (The final report must be worth at least 50% of final grade): Final grade will be based upon final report (at least 50%) and laboratory performance.
Project status: This project is taken. The professor has no more '396' projects this term.
How students can apply: N/A; this project is filled.
Ethics, safety, and training: Supervisors are responsible for the ethics and safety compliance of undergraduate students. This project involves: Handling chemicals.