'Mechanisms of Bacterial Antigen Facilitated Cancer Metastasis' - BIOL 396 Undergraduate Research Project Application Form
INSTRUCTIONS - PROFESSORS: Please print and review this form. Complete or correct the sections, as applicable, from "Supervisor's Name" to "Ethics, safety, and training". Please sign and date near the bottom ("Supervisor's signature").
INSTRUCTIONS - STUDENTS: You may receive this form by email, or you may download it after it has been posted here. Either way, print and review this form. Complete or correct the sections, from "Student's Name" to "Student's Level", and sign ("Student signature"). Ask your supervisor to sign her/his section near the bottom. Take it to the department* corresponding to the course number in Section A; this may or may not be your own department. (* EXCEPTIONS: For NSCI 396 and COGS 396, please bring it to the Interdisciplinary Programs Adviser in Dawson Hall.) Do not register for a '396' course on Minerva until you receive departmental permission. Have a discussion with your supervisor about time/work expectations, keeping in mind that this is a 3-credit course (roughly, 10 hours per week for 12 weeks). Remember that a '396' course is an elective.
INSTRUCTIONS - DEPARTMENTS: After the unit chair/director/designate approves (or not) this project, please notify student. If approved, please give student permission to register on Minerva, and send a copy of this form (with signatures) to the Office for Undergraduate Research in Science (either fax, or internal mail to Dawson Hall 408-A, or PDF scan + email).
QUESTIONS OR FEEDBACK? Contact the Office for Undergraduate Research in Science.
Supervisor's Name: Lorenzo Ferri
Supervisor's Email: lorenzo [dot] ferri [at] mcgill [dot] ca
Supervisor's Phone: 514 934 1934 44327
Supervisor's department: Surgery
Course number: BIOL396 (Biology)
Term: Fall 2012-2013
Project start date: Tuesday, September 4, 2012
Project end date: Tuesday, December 4, 2012
Project title: Mechanisms of Bacterial Antigen Facilitated Cancer Metastasis
Project description: Over the past decade there is mounting clinical evidence that post-operative infectious complications following cancer surgery increase recurrence in the form of distant metastasis. The mechanisms for this finding are unclear. Our group has recently demonstrated that many cancer cells express receptors to bacterial antigens termed Toll like receptors (TLRs). The students project will help elucidate the consequences of activation of these receptors on a panel of lung and colon cancers (H59, A549, HT-29, and MC 38) with a series of functional assays including adhesion to ECM components, endothelial cells, transmigration, and parallel plate flow chambers.
Prerequisite: 1 term completed at McGill + CGPA of 3.0 or higher; or permission of instructor.
Grading scheme (The final report must be worth at least 50% of final grade): Final grade shall be based on laboratory performance as evaluated by the research supervisor (50%) and the final written research report (minimum 10 pages) graded by the supervisor and the course coordinator or the coordinator's delegate (50%).
Project status: This project is taken. The professor has no more '396' projects this term.
How students can apply: N/A; this project is filled.
Ethics, safety, and training: Supervisors are responsible for the ethics and safety compliance of undergraduate students. This project involves NEITHER animal subjects, nor human subjects, nor biohazardous substances, nor radioactive materials, nor handling chemicals, nor using lasers.