'Characterization of FUS/TLS in a culture model of Amyotrophic Lateral Sclerosis' - NSCI 396 Undergraduate Research Project Application Form
INSTRUCTIONS - PROFESSORS: Please print and review this form. Complete or correct the sections, as applicable, from "Supervisor's Name" to "Ethics, safety, and training". Please sign and date near the bottom ("Supervisor's signature").
INSTRUCTIONS - STUDENTS: You may receive this form by email, or you may download it from www.mcgill.ca/science/research/ours/396 after it has been posted. Either way, print and review this form. Complete or correct the sections, from "Student's Name" to "Student's Level", and sign ("Student signature). Ask your supervisor to sign her/his section near the bottom. Take it to the department corresponding to the course number; this may or may not be your own department. Do not register for a '396' course on Minerva until you receive departmental permission. Have a discussion with your supervisor about time/work expectations, keeping in mind that this is a 3-credit course (roughly, 10 hours per week for 12 weeks). Remember that a '396' course is an elective.
INSTRUCTIONS - DEPARTMENTS: After the unit chair/director/designate approves (or not) this project, notify student. If approved, please give student permission to register on Minerva, and send a copy of this form (with signatures) to the Office for Undergraduate Research in Science (either fax 514-398-8102, or internal mail to Dawson Hall 408-A, or PDF scan + email).
QUESTIONS OR FEEDBACK? Contact Victor Chisholm by email, or phone 514-398-5964
Supervisor's Name: Dr. Heather Durham
Supervisor's Email: heather [dot] durham [at] mcgill [dot] ca
Supervisor's Phone: 514-398-8508
Supervisor's department: Neuroscience
Course number: NSCI396 (Neuroscience)
Term: Winter 2011-2012
Project start date: Monday, January 9, 2012
Project end date: Monday, April 16, 2012
Project title: Characterization of FUS/TLS in a culture model of Amyotrophic Lateral Sclerosis
Project description: Recently, mutations in the gene encoding Fused in Sarcoma/ Translated in Liposarcoma (FUS/TLS) were found to cause ALS, a neurodegenerative disease leading to preferential death of motor neurons. This DNA/RNA binding protein is normally found in the nucleus however its various functions in RNA processing and transport to dendrites require shuttling between the nucleus and the cytoplasm. In ALS, FUS is retained in the cytoplasm and forms inclusions. The characterization and toxic cellular effects of ALS causing FUS mutants as well as the dynamics of FUS inclusion formation must be understood in order to develop therapeutic interventions. We have developed a culture model in which motor neurons express mutant FUS. The project involves the characterization of FUS inclusions in motor neurons through co-localization studies as well as determining the dynamics of inclusion formation particularly in the context of neuronal activity through live cell imaging.
Prerequisite: 1 term completed at McGill + CGPA of 3.0 or higher; or permission of instructor.
Grading scheme (The final report must be worth at least 50% of final grade): 50% Lab Performance/Participation + 50% Final Report
Project status: This project is taken.
How students can apply: Send your CV and unofficial transcript to michael [dot] tibshirani [at] mail [dot] mcgill [dot] ca. N/A, this project is taken.
Ethics, safety, and training: Supervisors are responsible for the ethics and safety compliance of undergraduate students. This project involves: biohazardous substances; handling chemicals.
Student's McGill ID:
Student's Email (first [dot] last [at] mail [dot] mcgill [dot] ca):
Student's Level (U0 / U1 / U2 / U3):
Student's signature - I have not applied for another '396' course in this term:
Supervisor's signature - I give my permission for the student identified above to register for this project under my supervision:
Unit chair/director/designate's name:
Unit chair/director/designate's signature - I certify that this project conforms to departmental requirements for 396 courses: