'Role of PC5/6 in tumorigenesis' - ANAT 396 Undergraduate Research Project Application Form
INSTRUCTIONS - PROFESSORS: Please print and review this form. Complete or correct the sections, as applicable, from "Supervisor's Name" to "Ethics, safety, and training". Please sign and date near the bottom ("Supervisor's signature").
INSTRUCTIONS - STUDENTS: You may receive this form by email, or you may download it from www.mcgill.ca/science/research/ours/396 after it has been posted. Either way, print and review this form. Complete or correct the sections, from "Student's Name" to "Student's Level", and sign ("Student signature). Ask your supervisor to sign her/his section near the bottom. Take it to the department corresponding to the course number; this may or may not be your own department. Do not register for a '396' course on Minerva until you receive departmental permission. Have a discussion with your supervisor about time/work expectations, keeping in mind that this is a 3-credit course (roughly, 10 hours per week for 12 weeks). Remember that a '396' course is an elective.
INSTRUCTIONS - DEPARTMENTS:After the unit chair/director/designate approves (or not) this project, notify student. If approved, please give student permission to register on Minerva, and send a copy of this form (with signatures) to the Office for Undergraduate Research in Science (either fax 514-398-8102, or internal mail to Dawson Hall 408-A, or PDF scan + email).
QUESTIONS OR FEEDBACK? Contact Victor Chisholm by email, or phone 514-398-5964
Supervisor's Name: Dr. Peter Metrakos
Supervisor's Email: peter [dot] metrakos [at] mcgill [dot] ca
Supervisor's department: Anatomy and Cell Biology
Course number: ANAT396 (Anatomy and Cell Biology)
Term: Winter 2011-2012
Project start date: Monday, January 9, 2012
Project end date: Monday, April 16, 2012
Project title: Role of PC5/6 in tumorigenesis
Project description: Cancer progression can be mediated through numerous factors (stromelysins, MT-MMPs, integrins etc.) which are processed by proprotein convertases (PCs). This family of nine serine proteases is represented by: PC1/3, PC2, Furin, PC4, PC5/6, PACE4, PC7, SKI- 1/S1P and PCSK9. Knockout mouse models have stressed the essential or secondary role of PCs in the regulation of homeostasis and development. Many human tumor tissues and transformed cell lines overexpress or silence PC expression. Changes in expression pattern of PCs are found in various human tumors relative to their normal counterpart tissues in: breast tumors; squamous cell carcinoma, small-cell lung carcinoma; adenocarcinomas  small cell carcinoma cell lines [13, 14]; ovarian cancer cells and cell lines ; colon cancer and CRC cell lines. These modifications in PC expression were believed to be at the root cause of the tumorigenic phenotype of the cancers and cell lines.Recent findings in our lab demonstrate that colon cancer cells with reduced PC5/6 expression show less apoptotic capacity and greater adhesion-independent growth potential, suggesting that PC5/6 may protect against local tumour burden. We will further our understanding of the role of PC5/6 in colorectal cancer metastasis by generating an inducible PC5 transgenic mouse model and cell lines. The project consists of generating expression constructs (molecular biology), stable cell lines (cell biology) and protein expression analysis. The work proposed is part of a PhD project in the lab.
Prerequisite: 1 term completed at McGill + CGPA of 3.0 or higher; or permission of instructor.
Grading scheme (The final report must be worth at least 50% of final grade): 50% final report, 50% lab work
Project status: This project is taken. The professor has no more '396' projects this term.
How students can apply: N/A; this project is filled.
Ethics, safety, and training: Supervisors are responsible for the ethics and safety compliance of undergraduate students. This project involves animal subjects
Student's McGill ID:
Student's Email (first [dot] last [at] mail [dot] mcgill [dot] ca):
Student's Level (U0 / U1 / U2 / U3):
Student's signature - I have not applied for another '396' course in this term:
Supervisor's signature - I give my permission for the student identified above to register for this project under my supervision:
Unit chair/director/designate's name:
Unit chair/director/designate's signature - I certify that this project conforms to departmental requirements for 396 courses: