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'Processing of Caspase-6 by inflammatory Caspases' - ANAT 396 Undergraduate Research Project Application Form

INSTRUCTIONS - PROFESSORS: Please print and review this form. Complete or correct the sections, as applicable, from "Supervisor's Name" to "Ethics, safety, and training". Please sign and date near the bottom ("Supervisor's signature").

INSTRUCTIONS - STUDENTS: You may receive this form by email, or you may download it from www.mcgill.ca/science/research/ours/396 after it has been posted. Either way, print and review this form. Complete or correct the sections, from "Student's Name" to "Student's Level", and sign ("Student signature). Ask your supervisor to sign her/his section near the bottom. Take it to the department corresponding to the course number; this may or may not be your own department. Do not register for a '396' course on Minerva until you receive departmental permission. Have a discussion with your supervisor about time/work expectations, keeping in mind that this is a 3-credit course (roughly, 10 hours per week for 12 weeks). Remember that a '396' course is an elective.

INSTRUCTIONS - DEPARTMENTS: After the unit chair/director/designate approves (or not) this project, please notify student. If approved, please give student permission to register on Minerva, and fax this form (with signatures) to the Office for Undergraduate Research in Science at 514-398-8102. The Office for Undergraduate Research in Science will later post the project online at www.mcgill.ca/science/research/ours/396/listing, indicating whether the project is open for students to apply or taken.

QUESTIONS OR FEEDBACK? Contact Victor Chisholm by email, or phone 514-398-5964

Supervisor's Name: Andrea LeBlanc

Supervisor's Email: andrea [dot] leblanc [at] mcgill [dot] ca

Supervisor's Phone: 514-340-8222 ext 4976

Supervisor's Website: http://ladydavis.ca/en/andrealeblanc

Supervisor's department: Anatomy and Cell Biology; Neurology and Neurosurgery

Course number: ANAT396 (Anatomy and Cell Biology)

Term: Winter 2011-2012

Project start date: Monday, January 9, 2012

Project end date: Monday, April 16, 2012

Project title: Processing of Caspase-6 by inflammatory Caspases.

Project description: The goal of this project is to determine if inflammatory caspases process Caspase-6 at one or all of the three processing sites and lead to Caspase-6 activation. The student will use recombinant active enzymes to add to in vitro translated pro-Caspase-6. The student will then run a western blot with several antibodies to assess cleavage of Caspase-6. Lastly, the student will determine if the inflammatory caspases activate caspase-6 by using a fluorogenic substrate caspase activity assay. Each of the techniques and all of the tools for this project are established and present in the laboratory or can be commercially obtained. The result of these experiments will allow us to determine upstream activators of Caspase-6 in Alzheimer disease.

Prerequisite: 1 term completed at McGill + CGPA of 3.0 or higher; or permission of instructor.

Grading scheme (The final report must be worth at least 50% of final grade): Final grade shall be based on laboratory performance as evaluated by the research supervisor (50%) and the final written research report (minimum 10 pages) graded by the supervisor and the course coordinator or the coordinator's delegate (50%).

Other project information: Applicant should read our manuscripts on Caspase-6 and review the field of inflammatory caspases.

Project status: This project is taken. The professor has no more '396' projects this term.

How students can apply: N/A; this project is filled.

Ethics, safety, and training: Supervisors are responsible for the ethics and safety compliance of undergraduate students. This project involves NEITHER animal subjects, nor human subjects, nor biohazardous substances, nor radioactive materials, nor handling chemicals, nor using lasers.

Student's Name:

Student's McGill ID:

Student's Email (first [dot] last [at] mail [dot] mcgill [dot] ca):

Student's Phone:

Student's Program:

Student's Level (U0 / U1 / U2 / U3):

Student's signature - I have not applied for another '396' course in this term:

Supervisor's signature - I give my permission for the student identified above to register for this project under my supervision:

Date:

Unit chair/director/designate's name:

Unit chair/director/designate's signature - I certify that this project conforms to departmental requirements for 396 courses:

Date: