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'New Labelled Malaria Pigment Models' - CHEM 396 Undergraduate Research Project Application Form.

INSTRUCTIONS - PROFESSORS: Please print and review this form. Complete or correct the sections, as applicable, from "Supervisor's Name" to "Ethics, safety, and training". Please sign and date near the bottom ("Supervisor's signature").

INSTRUCTIONS - STUDENTS: You may receive this form by email, or you may download it from www.mcgill.ca/science/research/ours/396 after it has been posted. Either way, print and review this form. Complete or correct the sections, from "Student's Name" to "Student's Level", and sign ("Student signature). Ask your supervisor to sign her/his section near the bottom. Take it to the department corresponding to the course number; this may or may not be your own department. Do not register for a '396' course on Minerva until you receive departmental permission. Have a discussion with your supervisor about time/work expectations, keeping in mind that this is a 3-credit course (roughly, 10 hours per week for 12 weeks). Remember that a '396' course is an elective.

INSTRUCTIONS - DEPARTMENTS: After the unit chair/director/designate approves (or not) this project, please notify student. If approved, please give student permission to register on Minerva, and fax this form (with signatures) to the Office for Undergraduate Research in Science at 514-398-8102. The Office for Undergraduate Research in Science will later post the project online at www.mcgill.ca/science/research/ours/396/listing, indicating whether the project is open for students to apply or taken.

QUESTIONS OR FEEDBACK? Contact Victor Chisholm by email, or phone 514-398-5964

Supervisor's Name: Scott Bohle

Supervisor's Email: Scott [dot] Bohle [at] McGill [dot] CA

Supervisor's Phone: 514-398-7409

Supervisor's Website: http://bohle-group.mcgill.ca/

Supervisor's department: Chemistry

Course number: CHEM396 (Chemistry)

Term: Fall 2011-2012

Project start date: Wednesday, September 1, 2011

Project end date: Tuesday, December 6, 2011

Project title: New Labelled Malaria Pigment Models

Project description: New iron -57 labelled derivatives of malaria pigment will be prepared and used to test for the nature of heme-antimalarial drug interactions.  Know methods of iron metallation of protoporphyrin-IX will be tested and optimized and the products characterized by UV, IR, and Raman spectroscopy.  Once these new substrates are in hand they will be used for the synthesis of labeled malaria pigment which will then be characterized by the same array of methods.  This project will ultimately lead into the characterization malaria pigment by NRVS spectroscopy to assess the nature of the iron/antimalarial drug interaction.

Prerequisite: 1 term completed at McGill + CGPA of 3.0 or higher; or permission of instructor.

Grading scheme (The final report must be worth at least 50% of final grade): Laboratory performance, 50%; final report, 50%.

Project status - This project is: Taken; however students may contact the professor to discuss other possible '396' projects this term.

How students can apply: Bring a printed copy of this application form and your advising transcript to me during office hours.

Ethics, safety, and training: Supervisors are responsible for the ethics and safety compliance of undergraduate students. Which of the following, if any, is involved? None of the above (NEITHER animal subjects, nor human subjects, nor biohazardous substances, nor radioactive materials, nor handling chemicals, nor using lasers)

Student's Name:

Student's McGill ID:

Student's Email (first [dot] last [at] mail [dot] mcgill [dot] ca):

Student's Phone:

Student's Program:

Student's Level (U0 / U1 / U2 / U3):

Student's signature - I have not applied for another '396' course in this term:

Supervisor's signature - I give my permission for the student identified above to register for this project under my supervision:

Date:

Unit chair/director/designate's name:

Unit chair/director/designate's signature - I certify that this project conforms to departmental requirements for 396 courses:

Date: