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'Reactive oxygen species as mediators in Nod1 or Nod2 signalling' - MIMM 397 Undergraduate Research Project Application Form.

INSTRUCTIONS - PROFESSORS: Fill out Sections A & B then submit this form online. (You will receive an email copy of the form. The Office for Undergraduate Research in Science will also post the project online at http://www.mcgill.ca/science/research/ours/396/listing/, indicating whether the project is open for students to apply or taken.)

INSTRUCTIONS - STUDENTS: You may receive this form by email, or you may download it from www.mcgill.ca/science/research/ours/396/listing/ after it has been posted. Either way, print this form. Complete and sign Section C on the hardcopy. Ask your supervisor to sign Section D. Take it to the department corresponding to the course number in Section A (this may or may not be your own department). Do not register for a '396' course on Minerva until you receive departmental permission. Have a discussion with your supervisor about time/work expectations, keeping in mind that this is a 3-credit course (roughly, 10 hours per week for 12 weeks). Remember that a '396' course is an elective.

INSTRUCTIONS - DEPARTMENTS: After the unit chair/director/designate approves (or not) this project, notify student. If approved, please give student permission to register on Minerva, and fax this form (with signatures) to the Office for Undergraduate Research in Science at 514-398-8102.

QUESTIONS OR FEEDBACK? Contact Victor Chisholm by email, or phone 514-398-5964.

SECTION A: SUPERVISOR INFORMATION

Name:

Jorg Fritz

Email:

jorg [dot] fritz [at] mcgill [dot] ca

Phone:

514-398-1707

Website:

http://www.mcgill.ca/microimm/members/professors/fritz

Supervisor's department:

Microbiology and Immunology

Course number:

MIMM 397 (Immunology)

SECTION B: PROJECT INFORMATION

Term:

Summer 2011

Project start date:

02 May 2011

Project end date:

31 August 2011

Project title:

Reactive oxygen species as mediators in Nod1 or Nod2 signalling

Project description:

We hypothesize that the synergy of Nod1 and Nod2 with IFN-γ exerts critical antimicrobial activity through the induction oxidative stress signals leading to the production of chemokines such as CCL5/RANTES, CXCL9/MIG and CXCL10/IP-10, thereby facilitating the priming and recruitment of Ag-specific T cells to the site of infection for enhanced pathogen clearance. This project aims to define the induction of reactive oxygen species by Nod1- or Nod2-stimulating microbial constituents and its influence on chemokines production.

Prerequisite:

1 term completed at McGill + CGPA of 3.0 or higher; or permission of instructor.

Grading scheme (The final report must be worth at least 50% of final grade):

Final grade shall be based on laboratory performance as evaluated by the research supervisor (50%) and the final written research report (minimum 10 pages) graded by the supervisor and the course coordinator or the coordinator's delegate (50%).

Project status - This project is:

Taken. The professor has no more '396' projects this term.

How students can apply:

N/A; this project is filled.

Ethics, safety, and training

Which of the following, if any, is involved?

One or more of the following

Animal subjects

[x]

Human subjects

[ ]

Biohazardous substances

[x]

Radioactive materials

[ ]

Handling chemicals

[x]

Using lasers

[ ]

Supervisors are responsible for the ethics and safety compliance of undergraduate students.

SECTION C: STUDENT INFORMATION

Do not complete this section unless/until the student is identified.

Name:

 

McGill ID:

 

Email (first [dot] last [at] mail [dot] mcgill [dot] ca):

 

Phone:

 

Program (E.g., B.Sc. Maj. Chem. Min. Biol.):

 

Level (U0 / U1 / U2 / U3):

 

Student signature - I have not applied for another '396' course in this term:

 

SECTION D: APPROVALS.

Do not complete this section unless/until the student is identified.

Supervisor: I give my permission for the student identified in section C to register for this project under my supervision.

Supervisor's signature:

 

Date:

 

Unit chair/director/designate: I certify that this project conforms to departmental requirements for 396 courses.

Unit chair/director/designate's name:

 

Unit chair/director/designate's signature:

 

Date: