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'Characterization of GPNMB cleavage and biological activities of the shed ECD' Undergraduate Research Project Application Form.

INSTRUCTIONS - PROFESSORS: Fill out Sections A & B then submit this form online. (You will receive an email copy of the form. The Office for Undergraduate Research in Science will also post the project online, indicating whether the project is open for students to apply or taken.) DONE

INSTRUCTIONS - STUDENTS: You may receive this form by email, or you may download it, after it has been posted. Either way, print this form. Complete and sign Section C on the hardcopy. Ask your supervisor to sign Section D. Take it to the department corresponding to the course number in Section A (this may or may not be your own department). Do not register for a '396' course on Minerva until you receive departmental permission. Have a discussion with your supervisor about time/work expectations, keeping in mind that this is a 3-credit course (roughly, 10 hours per week for 12 weeks). Remember that a '396' course is an elective.

INSTRUCTIONS - DEPARTMENTS: After the unit chair/director/designate approves (or not) this project, notify student. If approved, please give student permission to register on Minerva, and fax this form (with signatures) to the Office for Undergraduate Research in Science.

QUESTIONS OR FEEDBACK? Contact Victor Chisholm by email, or phone 514-398-5964.

SECTION A: SUPERVISOR INFORMATION

Name: Peter Siegel

Email: peter [dot] siegel [at] mcgill [dot] ca (peter dot siegel at mcgill dot ca)

Phone: (514) 398-4259

Website:

Supervisor's department: Biochemistry

Supervisor's department (if none of the above)

Course number: BIOC396 (Biochemistry)

SECTION B: PROJECT INFORMATION

Term: Winter 2010-2011

Project start date: January 4, 2011

Project end date: April 8, 2011

Project title: Characterization of GPNMB cleavage and biological activities of the shed ECD.

Project description: The project will focus on the creation of mutants of GPNMB that cannot be processed to release the extracellular domain. In addition, experiments designed to determine whether the shed GPNMB ECD can promote the invasiveness of breast cancer cells will be tested. The project will involve tissue culture, in vitro invasion assays, mutagenesis experimets and the characterization of these mutants for their ability to be processed and the ECD shed into the media of cells.

Prerequisite: 1 term completed at McGill + CGPA of 3.0 or higher; or permission of instructor.

Other prerequisite, if applicable:

Grading scheme (The final report must be worth at least 50% of final grade): 50% evaluation based on work in the lab and 50% based on the submitted lab report.

Other project information:

Project status - This project is: Taken. The professor has no more '396' projects this term.

How students can apply: N/A; this project is filled.

If other, please specify:

Ethics, safety, and training

Which of the following, if any, is involved? One or more of the following

Animal subjects [ ]

Human subjects [ ]

Biohazardous substances [x]

Radioactive materials [ ]

Handling chemicals [ ]

Using lasers [ ]

Supervisors are responsible for the ethics and safety compliance of undergraduate students.

SECTION C: STUDENT INFORMATION

Do not complete this section unless/until the student is identified.

Name:

McGill ID:

Email (first [dot] last [at] mail [dot] mcgill [dot] ca):

Phone:

Program (E.g., B.Sc. Maj. Chem. Min. Biol.):

Level (U0 / U1 / U2 / U3):

Student signature - I have not applied for another '396' course in this term:

SECTION D: APPROVALS.

Do not complete this section unless/until the student is identified.

Supervisor: I give my permission for the student identified in section C to register for this project under my supervision.

Supervisor's signature:

Date:

Unit chair/director/designate: I certify that this project conforms to departmental requirements for 396 courses.

Unit chair/director/designate's name:

Unit chair/director/designate's signature:

Date: