INSTRUCTIONS - PROFESSORS: Fill out Sections A & B then submit this form online. (You will receive an email copy of the form. The Office for Undergraduate Research in Science will also post the project online, indicating whether the project is open for students to apply or taken.) DONE
INSTRUCTIONS - STUDENTS: You may receive this form by email, or you may download it after it has been posted. Either way, print this form. Complete and sign Section C on the hardcopy. Ask your supervisor to sign Section D. Take it to the department corresponding to the course number in Section A (this may or may not be your own department). Do not register for a '396' course on Minerva until you receive departmental permission.
INSTRUCTIONS - DEPARTMENTS: After the unit chair/director/designate approves (or not) this project, notify student. If approved, please give student permission to register on Minerva, and fax this form (with signatures) to the Office for Undergraduate Research in Science.
QUESTIONS OR FEEDBACK? Contact Victor Chisholm by email, or phone 514-398-5964.
| SECTION A: SUPERVISOR INFORMATION | |
|---|---|
| Name: | Sandra C. Miller |
| Email: | sandra [dot] miller [at] mcgill [dot] ca (sandra dot miller at mcgill dot ca) |
| Phone: | 514-398-6358 |
| Website: | |
| Supervisor's department: | Anatomy and Cell Biology |
| Course number: | ANAT396 (Anatomy and Cell Biology) |
| SECTION B: PROJECT INFORMATION | |
| Term: | Fall 2010-2011 |
| Project start date: | September 1, 2019 |
| Project end date: | December 3, 2010 |
| Project title: | Effect of ginseng on non-adaptive immunity in aged mice. |
| Project description: | The project consists of enhancing the non-adaptive (NK cell-mediated) immunity of aged, female C3H mice. NK cells are the first line of defense against cancers. C3H mice are an animal model of human breast cancer. Our intention is to administer a known immunostimulant, CVT-E002, a standardized derivative of North American ginseng, via the diet daily (80mg/day/mouse) for 3 weeks. Thus, prior to our ultimate goal of assessing the role of CVT-E002 as an NK stimulant during the actual development of breast cancer in aged female mice of this strain, we must first assess its role as an NK stimulant in normal, aged female mice. After 3 weeks of dietary administration of this agent, we will euthanize CVT-E002-fed mice and identical control mice consuming the same diet but without CVT-E002. To date, it is completely unknown whether or not aged mice fed this derivative will show NK cell enhancement. Upon euthanization at 3 weeks, the blood, spleen, and bone marrow of each mouse will be extracted, and prepared for NK cell assessment via the light microscope, by means of special staining. These organs will be assessed for any quantitative elevation (or lack thereof) of NK cells in CVT-E002-fed mice vs. control. Our hypothesis is that there will be such an elevation, given the evidence of young adult mice of this strain and others. Nevertheless, since the entire immune system of all mammalian species always decline with age, we cannot be dogmatic about the hypothesis, and hence the need for the present study. |
| Prerequisite: | 1 term completed at McGill + CGPA of 3.0 or higher; or permission of instructor. |
| Other prerequisite, if applicable: | |
| Grading scheme (The final report must be worth at least 50% of final grade): | 50% final report and 50% in-course work. |
| Other project information: | |
| Project status - This project is: | Taken. The professor has no more '396' projects this term. |
| How students can apply: | N/A; this project is filled. |
| If other, please specify: | |
| Ethics, safety, and training | |
| Which of the following, if any, is involved? | One or more of the following |
| Animal subjects | [x] |
| Human subjects | [ ] |
| Biohazardous substances | [ ] |
| Radioactive materials | [ ] |
| Handling chemicals | [ ] |
| Using lasers | [ ] |
| Supervisors are responsible for the ethics and safety compliance of undergraduate students. | |
| SECTION C: STUDENT INFORMATION | |
| Do not complete this section unless/until the student is identified. | |
| Name: | |
| McGill ID: | |
| Email (first [dot] last [at] mail [dot] mcgill [dot] ca): | |
| Phone: | |
| Program (E.g., B.Sc. Maj. Chem. Min. Biol.): | |
| Level (U0 / U1 / U2 / U3): | |
| Student signature - I have not applied for another '396' course in this term: | |
| SECTION D: APPROVALS. | |
| Do not complete this section unless/until the student is identified. | |
| Supervisor: I give my permission for the student identified in section C to register for this project under my supervision. | |
| Supervisor's signature: | |
| Date: | |
| Unit chair/director/designate: I certify that this project conforms to departmental requirements for 396 courses. | |
| Unit chair/director/designate's name: | |
| Unit chair/director/designate's signature: | |
| Date: | |