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Undergraduate Research Project Application Form

INSTRUCTIONS - PROFESSORS: Fill out Sections A & B then submit this form online. (You will receive an email copy of the form. The Office for Undergraduate Research in Science will also post the project online, indicating whether the project is open for students to apply or taken.) DONE
INSTRUCTIONS - STUDENTS: You may receive this form by email, or you may download it after it has been posted. Either way, print this form. Complete and sign Section C on the hardcopy. Ask your supervisor to sign Section D. Take it to the department corresponding to the course number in Section A (this may or may not be your own department). Do not register for a '396' course on Minerva until you receive departmental permission.
INSTRUCTIONS - DEPARTMENTS: After the unit chair/director/designate approves (or not) this project, notify student. If approved, please give student permission to register on Minerva, and fax this form (with signatures) to the Office for Undergraduate Research in Science at 514-398-8102.
QUESTIONS OR FEEDBACK? Contact Victor Chisholm by email, or phone 514-398-5964.
Name: Josée Dostie
Email: josee [dot] dostie [at] mcgill [dot] ca
Phone: 514-398-4975
Website: http://dostielab.biochem.mcgill.ca/
Supervisor's department: Biochemistry
Supervisor's department (if none of the above)  
Course number: BIOC396 (Biochemistry)
Term: Winter 2010
Project start date: January 4, 2010
Project end date: April 14, 2010
Project title: In vivo 3D modeling of the mouse HoxA cluster
Project description: The goal of this project is to solve the three-dimensional chromatin organization of the mouse HoxA gene cluster. To achieve this goal, the P19 cell line and embryonic stem cells expressing various levels of HoxA genes will be analyzed using 3C (Chromosome Conformation Capture) and 5C (3C-Carbon Copy) technologies. Gene expression will be quantified by real-time qPCR. 3C libraries will be characterized by conventional gel detection and quantification. 5C libraries will be analyzed on custom microarrays. 3C and 5C datasets will be modeled bioinformatically using a number of 3D modeling programs to identify 3D molecular signatures of active and silent HoxA expression.
Prerequisite: 1 term completed at McGill + CGPA of 3.0 or higher; or permission of instructor.
Other prerequisite, if applicable:  
Grading scheme (The final report must be worth at least 50% of final grade): Lab performance (50%), 10-page lab report (50%)
Other project information:
Project status - This project is: Taken; however students may contact the professor to discuss other possible '396' projects this term.
How students can apply: Bring a printed copy of this application form and your advising transcript to me during office hours.
If other, please specify:  
Ethics, safety, and training
Which of the following, if any, is involved? One or more of the following
Animal subjects [ ]
Human subjects [ ]
Biohazardous substances [x]
Radioactive materials [ ]
Handling chemicals [ ]
Using lasers [ ]
Supervisors are responsible for the ethics and safety compliance of undergraduate students.
Do not complete this section unless/until the student is identified.
McGill ID:  
Email (first [dot] last [at] mail [dot] mcgill [dot] ca):  
Program (E.g., B.Sc. Maj. Chem. Min. Biol.):  
Level (U0 / U1 / U2 / U3):
Student signature - I have not applied for another '396' course in this term:  
Do not complete this section unless/until the student is identified.
Supervisor: I give my permission for the student identified in section C to register for this project under my supervision.
Supervisor's signature:  
Unit chair/director/designate: I certify that this project conforms to departmental requirements for 396 courses.
Unit chair/director/designate's name:  
Unit chair/director/designate's signature: