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Neurodevelopmental disorders (NDDs) such as autism or intellectual disability remain a disease category where no therapeutic intervention exists beyond symptom management or behavioral therapies.  Breakthroughs in genome sequencing, human stem cell biology, and small molecule screening provide a unique opportunity to understand and possibly treat neurodevelopmental disorders.  The lab focuses on NDDs caused by reduced gene dosage and NDDs associated with genes with a known role in metabolism.   Our hope is to model genetically defined disorders, to identify cellular and molecular phenotypes relevant to disease, and to develpp drug screening assays based on these phenotypes.