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Our group studies psychiatric disorders with a focus on neurodevelopmental disorders, using Next-Generation sequencing technology and stem cell biology.

There are three main themes in the lab:

1) Identification of genetic variation/mutations associated with neurodevelopmental disorders.  This involves recruiting patients and their families, collecting DNA samples, and using high throughput technologies to identify potentially causative genetic alterations.

2) Molecular studies of gene dosage.  Molecular studies in our group focus on understanding why genetic dosage (amount of gene product) of some genes is fundamental to proper development of the nervous system.

3) Epigenetic studies of addiction, mood disorders, or suicidal behavior.  Using human brain tissue from the brain bank at the Douglas Hospital, we study modifications to the genome that may be related to suicide, mood, or drugs of abuse such as cocaine.

 

Karyotype of normal human chromosomes