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The Chair’s Missive

Dr. John Orlowski




As the calendar year turns over, despite being in the middle of our academic year, it is perhaps a good a time as any to briefly reflect on changes in the Department and highlight some upcoming exciting events as we build and shape the future of the Department.  

The heart of any organization is its people, and thus it was with much regret that we fondly bade farewell to two of our gifted and well-liked junior faculty members (Drs. Julia Desbarats and Peter Swain) who chose to leave McGill to pursue other opportunities.   However, for every yin there is a yang as our academic ranks were reinvigorated by the successful hiring of three very talented individuals, Drs. Gergely Lukacs, Russell (Rusty) Jones (also a member of the Goodman Cancer Centre), and Melissa Vollrath (also a member of the Department of Neurology and Neurosurgery). Their recruitment brings much needed strength and excitement in several emerging areas of scientific inquiry: (1) molecular mechanisms that underlie protein folding and trafficking as it relates to health and disease (Dr. Lukacs); (2) cellular energy metabolism & immunology (Dr. Jones); (3) and the molecular, cellular and electrophysiological basis of mechanotransduction in the auditory and vestibular systems (Dr. Vollrath).  In addition, though there is an apparent University-wide “hiring freeze”, recruitment nevertheless will continue to be a priority for the coming year(s) as we, along with other basic biomedical departments, seek to fill a limited number of positions made available to the Faculty of Medicine for the various Research Themes of the newly inaugurated Bellini Life Sciences Complex and Goodman Cancer Centre.  I hope to have more to say on faculty recruitment in the very near future. 

While on the topic of the Bellini Life Sciences Complex, as you all know Dr. Alvin Shrier is the Leader responsible for developing the Cell Information Systems Theme which occupies the first floor of the Bellini Building.  As part of this process, Drs. Pejmun Haghighi, Alvin Shrier (partly), Gergely Lukacs (partly) and I have moved our laboratories (or certain operational aspects) over to this wonderful new facility where we join some of our colleagues (Anne McKinney and Derek Bowie) from the Department of Pharmacology and Experimental Therapeutics! The Microscopy and FACS facilities are up and running in the new space, and we will soon be adding three new state-of-the-art microscopes for live cell imaging as well as other applications.  This promises to be a very exciting time as we build bridges between disciplines and tackle new challenges in health science research. 

Aside from changes in our academic ranks, we have also experienced a change in the Office Staff with the recent departure of our administrative wizard, Ms. Wendy Marshall, who has taken a personal leave-of-absence.  While the odds of finding a comparable replacement seemed lower than winning the 6/49 lottery, fortune smiled upon us with the arrival of Ms. Terry Kaluta who brings with her an impressive array of organization and managerial skills and a deep understanding of the way McGill works.   Needless-to-say, we remain in excellent hands!

This coming year we also face a considerable administrative challenge as, at the request of the Faculty of Medicine, we undertake the first cyclic review of the Department’s activities – past and present time - in over 15 years.  This is an important and major undertaking that will require the input from all levels of the Department as we examine our individual and collective accomplishments, and develop our vision for the future.  You will hear more about this endeavour in the weeks to come.

As we march into the winter semester, I wish to bring to your attention a number of exciting events being hosted by the Department.  These include the Departmental Faculty Shop-Talk Soiree to be held on Feb 12th at the Faculty Club, the annual F.C. MacIntosh  Lectureship given by Dr. Walter Boron from Case Western Reserve University (March 20th),  and our undergraduate (March 27th) and graduate (May 8th) research day symposiums.  These are wonderful occasions that highlight the scientific excellence of our students, faculty and invited colleagues and should not be missed, so marked them on your calendars!

In closing, the health of the Department remains strong and vibrant as we meet our various research, teaching and administrative responsibilities.  I wish you all continued success throughout the coming year.


The Department 
 

The Fall term was pretty smooth sailing and the students kept the staff in the General Office, Maria and Lauren and Sonia busy.  All teaching labs went well under the direction of Domnica and Rosy.  And this coming term will be even better as the lab has all new computers purchased under the Science Undergrad Lab Improvement Funding received from the Faculty of Science and matched by the Faculty of Medicine.  Anna-Maria took great care of our seminar guest speakers and continues to do a fantastic job of assisting Dr. Orlowski.  Wendy took a leave of absence this past fall and Terry is attempting to fill her shoes while she’s away 

In November the department had an evening retreat at the Faculty Club and Dr. Prem Ponka presented what his research has been focusing on these days.  We also had a representative from the Teaching and Learning Office, Mr. Adam Finkelstein, present on different teaching methods being used.  Another retreat is planned for mid February with planned speakers to be Dr. Cathy Cullen and Dr. Ellis Cooper.


The December holiday party was very well attended and a fun time was had by all.  It was delightful to see the children enjoying their toys specially delivered by Santa!

 


 


Kudos 

·         Said Izreig, doctoral student (Dr. Jones’ Lab) recently won the JBC/Herbert Tabor Young Investigator Award at a recent FASEB Meeting AMPK: Biological Action and Therapeutic Perspectives held in Barga, Italy for his presentation entitled:” Repression of LKB1 by miR-17-92 is required for Myc- driven metabolism in B-cell lymphoma”. 

·         Bojing (Blaire) Jia (Dr. Brown’s Lab) won the 2nd prize in the Cellular and Molecular Biology category at the Undergraduate Research Conference (URC) of the Faculty of Science. 

·         Dr. Eric Cook’s Canada Research Chair was renewed for another 5 year term

·         Dr. Eric Cook and Dr. Julio Martinez-Trujilo received three year grants from the EJLB Foundation under the Scholar Research Program.

·         Dr. John White and his co-PI Marcel Behr (MGH) received a $250,000 grant (over two years) from an internal McGill call for proposals on nutrition to study the molecular genetic events underlying the suppression by vitamin D of Mycobacterium tuberculosis replication in infected macrophages.

·         Dr. Alvin Shrier was awarded a three year China-Canada research grant to collaborate with Dr. Liu and Jiang at the Sun Yat-Sen University.

·         Dr. Renaud Robert, postdoc fellow (Dr. Hanrahan’s Lab) was recently awarded a Chemical Biology Training Program Postdoctoral Fellowship and the McGill internal fellowship Mc Laughlin.

·         Pierre Lesimple, postdoc fellow (Dr. Hanrahan’s Lab), was recently awarded a Montreal Chest Institute - Research Centre  (MCI-RC) Fellowship.

·         Valerie Walker (Dr. Shrier’s Lab) recently won a prize for her poster at the first GRASP meeting held this past fall. Grasp is a new FRSQ Team headed by Kalle Gehring which was recently funded.

·         M.  Kodiha (Dr. Stochaj’s Lab) (2008) Recipient of the Canadian Cardiovascular Society Academy (CCSA) “Have-a-Heart Bursary” program award.


Graduate Program News 
 

The Graduate program has 56 graduate students registered; a number which is stable:  40 PhD, 14 Masters and 21 Post-Doctoral.  A Program recruitment information session was held in October 2008; invited were undergraduate students from science programs at McGill and other Montreal area Universities.  We’re always looking for graduate students!  Please refer to our website so see which of our faculty members have openings. 

Defences

Mr. Nick Masse (Dr. Cook’s Lab) presented his oral defence on Thursday, December 18, 2008The title of his presentation: How neural activity underlies visual motion perception.

New Grads September 2009

Melody Aghourian (M.Sc.) - Dr. M. Blostein's lab
Genevieve Bates (Qualifying term) - Dr. A-M. Lauzon's lab
Ari Bitton (M.Sc.) - Dr. J. White's lab 
Drew Countryman (Ph.D.) - Dr. J. Hanrahan's Lab
Lamine Diallo (Qualifying yr)
Catherine Gross (M.Sc.) - Dr. S. Musallam's lab 
Navid Khosravi (M.Sc.) - Dr. M. Chacron's lab
Faisal Naqib (M.Sc.) - Dr. Christopher Pack's lab
Bryan Ross (M.Sc.) - Dr. C. Rohlicek's lab
Aliona Rudchenko (Ph.D.) - Dr. E. Cooper's lab
Greg Stacey (Ph.D.) - Dr. S. Musallam's lab 
Georgios Tsoulfas (M.Sc.) - Dr. S. Musallam's lab

New Postdoctoral Fellows

Dr. Katrin Vonderschen    -    Dr. M. Chacron's lab   

New Graduate Students January 2009

Genevieve Bates (MSc) - Dr. Anne-Marie Lauzon
Alex Hodge  (M.Sc.) - Drs. A. Shrier & L. Glass
Diana Mitchell (M.Sc.) - Dr. K. Cullen
Asmae Moursli - Qualifying term
Melissa Savard (Ph.D.) - Dr. M. Chacron
Adeline Wohlhuter (Ph.D.) - Dr. J. Hanrahan

New Postdoctoral Fellows January 2009

Dr. Bryan Tripp - Dr. E. Cook's lab


PULS (Physiology Undergraduate League of Students) News 
 

Contributor:  Nicholas Avdimiretz, PULS Vice-President

The past period:

Congratulations PULS, the Physiology Undergraduate League of Students, for winning 1st place (for the second year in a row) in the SUS Charity Fair 2008 Interdepartmental Competition. PULS raised over $6,000 for Leucan, a non-profit organization that benefits cancer-stricken children and their families. PULS would like to extend a big thank you to all the Physiology students and staff who made this charitable contribution possible.

The future period:

JUMPS:  The Journal of Undergraduate McGill Physiology Students is a yearly scientific journal written and edited by McGill Physiology students. The journal is only in its second year of publication however it has already attracted much attention. The 2008-2009 edition will be published mid-March. If you are a student and would like to see your research project or review published, or if you are interested in an editing position, contact puls [at] sus [dot] mcgill [dot] ca for more information.

Wine & Cheese:  PULS would like to get the Physiology Faculty members involved with their wine & cheese event, held at the beginning of March. Similar to previous years, the event will involve a silent auction for charity in which students bid on spending time with their favourite professors. This year, PULS would like to invite all Physiology professors to attend the event, and possibly give a short speech about their research initiatives and recent publications. PULS will be contacting faculty members later in the semester.

Professor of the Year Award:  PULS would like to make all Physiology professors aware of the Dr. Ann Wechsler Award for Excellence in Teaching of Physiology, awarded on Physiology Undergraduate Research Day. This award recognizes the outstanding skills and excellence of professors in the Department of Physiology. Students will begin nominations and voting this semester.

Ski Trip:  The annual Physiology Ski Trip to Mont St. Anne is scheduled for the weekend of January 23rd. PULS will be coordinating transportation, equipment, and lodging. Everyone is welcome to attend.


News from Dr. Thomas M.S. Chang’s Lab 
 

In September, Dr. Chang was a Plenary Lecturer on “therapeutic application of artificial cells in nanomedicine” at the 4th Annual Symposium of the American Academy of Nanomedicine, Washington D.C.(Potomac).  Then in October was an opening keynote lecturer on “Artificial Cells containing stem cells for regenerative medicine” at the Session on Regenerative Medicine of the 6th Annual International Conference on Drug Discovery Science and Technology, Beijing, China.  On way to this meeting he visited his hometown Shantou University to be appointed Guest Professor at a special ceremony and to lecture to their Multidisciplinary Research Centre and as well to the medical students.

He has just been appointed to the board of directors of the American Academy of Nanomedicine and has been invited to be one of the founding members to participate in the organization of the new International Academy of Nanomedicine and to be on its board of directors.  Most likely you will not see him much in the first two months of the new year since he will be concentrating on the time consuming work of preparing the renewal application for his 5 year CIHR operating grant.

Google has placed his 2007 monograph on Artificial Cells on their website for all to freely preview the complete book; the link can be found on his website at www.artcell.mcgill.ca. A search for “artificial cells” shows more than 50,000 hits and is listed as either 1st or 2nd. 

Ms. Wei He has just completed her research project with Professor Chang for her M.Ss. in McGill’s Biotechnology Program and did well in her final oral.

Dr. HongLi Zhu from the NorthWest University, Xian,China has been in this laboratory since September as  a visiting scholar for 1 year.


News from Dr. Eric Cook’s Lab 
 

Post doctoral fellow Bryan Tripp joined the lab in December.  Bryan received his PhD from the University of Waterloo.

Graduate student Nick Masse completed his PhD and is now a post doc at the MRC Laboratory of Molecular Biology in Cambridge England.


News from Dr. Leon Glass’s Lab 
 

At the 2008 SIAM Meeting on the Life Sciences in Montreal in August 2008, Roy Wilds presented work from the paper "Evolution of Complex Dynamics", describing the connection between neutral mutations and increased evolvability in a model of genetic networks.

Former PhD student Eric Libby completed a AAAS Mass Media Science & Engineering Fellowship in the Summer of 2008 and will start a postdoctoral fellowship in New Zealand in February 2009.

Invited Lectures:

Leon Glass - SIAM Meeting on the Life Sciences, Montreal, August 2008; EMBC Annual Meeting, Vancouver, BC, August 2008 (Plenary Lecture); XVIII International Conference of the Cardiovascular Systems Dynamics Society, Saint Louis, MO, September 2008; Dynamical Systems in Physiological Modeling, Purdue University, West Lafayette, Indiana, October 2008 (Plenary Lecture); NHLBI-VCU Workshop on Workshop on Differential Equation Models in Cardiovascular and Cardiopulmonary Modeling and Simulations, October 2008.


News from Dr. John W. Hanrahan’s Lab
 

Welcome to:

Drew Countryman, Ph.D. student.

Presentations:

 

December 2008 - Invited Seminar, Cystic Fibrosis Center, University of North Carolina at Chapel Hill, also went horseback riding (photo) & horse survived.
October 2008 - Symposium Chair and Brown bag lunch organizer, North American Cystic Fibrosis Conference, Orlando, FL.
September 2008 - Invited Seminar, Cystic Fibrosis Center, University of Iowa, IA.
July 2008 - Invited Seminar, Department of Physiology and Biophysics, Dalhousie University, Halifax, NS.
July 2008 - Invited Seminar, Cell, Development & Biomedicine, University of East Anglia, Norwich, UK.
July 2008 - Speaker, The Physiological Society, Cambridge, UK



Dr. Robert: “Correction of ∆F508-CFTR trafficking defect by the bioavailable compound JMCG811” at the Symposium Québec-France, Réseau en Santé Respiratoire du Québec (RSRQ), Québec, Canada, December 3-5, 2008.

Best Wishes to:

Ian Bates, postdoc fellow in the lab who accepted a position at Zeiss as Imaging specialist.
Catalin Pavel, visiting graduate student from the Univ. Copenhagen who accepted a position at Olympus as a technical specialist.
Good luck in your new positions!

More good news:

Congratulations and best wishes to Na Liu on the birth of her son, Jason Cheng, on July 4, 2008 weighing 3.2 kg. 
Congratulations and best wishes to Alexandra Evagelidis on the birth of her daughter, Katherine on December 9, 2008 weighing 8lbs 03oz.

News from Dr. Michael C. Mackey’s Lab

Student news:  Raluca Apostu attended a Summer School on Stochastic Differential Equation Models with Applications to the Insulin-Glucose System and to Neuronal Modeling, Denmark, August 2008.  Catherine Foley defended her doctoral dissertation (Mathematics) with flying colors this past summer and had a splendid graduation at the November convocation.  Mary Walsh (This Hour has 22 Minutes) came to honour her with a rousing address much enjoyed by all of us. Lennart Hilbert, a Physics student from the University of Bremen (Prof. dr. Peter Richter), is visiting our group for three months working on aspects of Brownian motors.

Dr. Mackey’s news:  Reentry into the McGill scene was not easy for me after a year away.  The month of July was spent hosting all of our children, spouses, and grandchildren which was interesting, fun (and somewhat emotionally exhausting) all at the same time.  I had (thankfully) a good 10 days in Dresden at an August workshop on irreversibility at one of the Max Planck institutes to recover.  Teaching started in September, of course, and my colleague Dr. Tyran arrived late September for a 5 week period in which we worked on a problem involving modeling  protein bursting in bacteria.  When she left, Dr. Santillan came from Mexico for the month of November and we worked on extensions of our research involving Brownian motors.

 


News from Dr. Prem Ponka’s Lab 
 

Congratulations to:

Dr. Daniel Vyoral (former postdoctoral fellow) who was promoted to the rank of Associate Professor at the Faculty of Medicine, Charles University, Prague.

Carlos Sarmento who successfully completed his MSc dissertation “Assessment of New Iron Chelating Agents for Treatment of Iron Overload” and Tanya Kahawita who successfully completed her MSc dissertation “Evidence for physical Interaction of Endosomes with Mitochondria in Erythroid Cells”.

Dr. Ponka was appointed to the Scientific Council, First Faculty of Medicine, Charles University, Prague.

Welcome to:

Jesse Eisenberg, a physiology student who is enrolled in PHGY 461 and Arielle Mendel an Arts & Science student with a specialization in physiology who is enrolled in PHGY 396.

Speaking engagements:

Invited Speaker at the NIH/NIDDK sponsored Workshop on Heme Regulation during Erythropoiesis, Bethesda, September 16-17, 2008, Bethesda; the title of his talk was “Iron and Heme: Their Exquisite Relationship Makes Blood Red”.

Featured Speaker in the series of regular soirées known as “Chair for Dr. Faust” at the Academic Club of the First Faculty of Medicine, Charles University, Prague, September 24, 2008.

Invited Speaker at the East Coast Iron Club 2008 at The State University of New York at Buffalo, October 31, 2008; the title of his talk was: “Iron Metabolism in Erythroid Cells, Cells Forgotten by 'Iron People', is Unique”.

Invited Speaker at the Department of Biochemistry, University of Vermont College of Medicine, November 7, 2008; the title of his talk was “Iron and Heme: Our Friends and Foes”.

Invited Speaker at the XIV Biennial Meeting of the Society for Free Radical Research International (14th SFRR), Beijing, China, October 18-22, 2008; the title of his talk was “New Advances in Iron Metabolism”

Chair of the Scientific Committee on Iron and Heme at the American Society of Hematology Meeting (San Francisco, CA, December 6-9, 2008) entitled “...why our Blood is Red” (John Donne, 1572-1631). The title of his talk was “The Path of Iron from Plasma Transferrin to Hemoglobin in Developing Red Blood Cells”

Oral presentation at the 50th Annual Meeting of the American Society of Hematology Meeting, San Francisco, CA, December 6-9, 2008 entitled “Nramp1 Promotes Efficient Macrophage Recycling of Iron Following Phenylhydrazine-Induced Hemolytic Anemia” (presented by Shan Soe-Lin).

Poster presentation at the 50th Annual Meeting of the American Society of Hematology Meeting, San Francisco, CA, December 6-9, 2008 entitled “Role of heme oxygenase 1 in erythroid differentiation” (presented by Daniel Garcia-Santos).

Poster presentation at the 50th Annual Meeting of the American Society of Hematology Meeting, San Francisco, CA, December 6-9, 2008 entitled “A closer look at cellular iron metabolism in IRP2 deficient erythroblasts” (presented by Matthias Schranzhofer).

Grant Reviewer: Erythrocyte & Leukocyte Biology (ELB) Study Section, National Institutes of Health, Bethesda, June 19, 2008.

 


Recent Publications/Abstracts  
 

Publications:

Mehaffey, W.H., Ellis, L.D., Krahe, R., Dunn, R.J., Chacron, M.J. (2008). Ionic and Neuromodulatory Regulation of Burst Discharge Controls Frequency Tuning. Journal of Physiology (Paris) doi: 10.1016/j.physparis.2008.10.019.

Krahe, R., Bastian, J., Chacron, M.J. (2008). Temporal processing across multiple topographic maps in the electrosensory system. Journal of Neurophysiology 100: 852-867.

Chacron, M.J., Bastian, J. (2008). Population Coding by Electrosensory Neurons. Journal of Neurophysiology 99: 1825-1835

M. Mase, L. Glass, F. Ravelli. A model for mechano--electrical feedback effects on atrial flutter interval variability. Bulletin of Mathematical Biology, 70, 1326-47 (2008)

C. Lerma, N. Wessel, A. Schirdewan, J. Kurths, L. Glass. Ventricular arrhythmias and changes of heart rate preceding ventricular tachycardia in patients with an implantable cardioverter defibrillator. Medical & Biological Engineering & Computing 46, 715-727 (2008)

R. Wilds, S. A. Kauffman, L. Glass. Evolving complex dynamics. Chaos 18, 033109 (2008) (7 pages)

S. Cardin, P. Pelletier, E. Libby, S. Le Bouter, L. Xiao, S. Kaab, S. Demolombe, L. Glass, S. Nattel. Marked differences between atrial and ventricular gene-expression remodeling in dogs with experimental heart failure. Journal of Molecular and Cellular Cardiology 45, 821-831 (2008)

L. Glass. Book Review of  Genomic Signal Processing by Ilya Shmulevich and Edward R. Dougherty, SIAM Review 50, 604-606 (2008) 

L. Glass, Response to Macklem's Viewpoint “Emergent phenomena'' Journal of Applied Physiology 104, 1850 (2008).

Luo Y, McDonald K, Hanrahan JW 2008. Trafficking of immature ΔF508 CFTR to the plasma membrane and its detection by biotinylation. Biochem J. doi:10.1042/BJ20081869

Michoud MC, Robert R, Hassan M, Moynihan B, Haston C, Govindaraju V, Ferraro P, Hanrahan JW and Martin JG 2008. Role of the CFTR channel in human airway smooth muscle. Am. J. Respir. Cell. Mol. Biol. doi:10.1165/rcmb.2006-0444OC

Seavilleklein G, Amer N, Evagelidis A, Chappe F, Hanrahan JW and Chappe V 2008. PKC phosphorylation modulates PKA-dependent binding of the R domain to other domains of CFTR. Am J Physiol Cell Physiol., 295(5):C1366-75.

Chappe FG, Loewen ME, Hanrahan JW and Chappe VM 2008. VIP increases CFTR levels in the apical membrane of Calu-3 cells through a PKC-dependent mechanism. J Pharmacol Exp Ther., 327(1):226-38.

Ianowski JP, Choi JY, Wine JJ and Hanrahan JW 2008. Substance P stimulates CFTR-dependent fluid secretion by mouse tracheal submucosal glands. Pflugers Arch., 457(2):529-37.

Wang B, Heath-Engel H, Zhang D, Nguyen N, Thomas DY, Hanrahan JW and Shore GC 2008. BAP31 associates with the Sec61 translocon and promotes retrotranslocation of CFTRΔF508 from the endoplasmic reticulum via the Derlin-1 complex. Cell 133:1080-92.

Hanrahan JW 2008. CFTR-dependent anion transport in airway epithelia. In Epithelial Transport Physiology, Chapter 5, ed. G.A. Gerenscer, The Humana Press, Totawa, NJ, in press

M. Santillan and M. C. Mackey. “Quantitative approaches to the study of bistability in the lac operon of Escherichia coli", J. Roy. Soc. Interface (2008),5,S29-40.

M.C. Mackey and M. Tyran-Kaminska. “Dynamics and    density evolution in piecewise deterministic growth processes", Annales Polonici Mathematici (2008), 94 111-129.

Soe-Lin S, Sheftel AD, Wasyluk B, Ponka P. “Nramp1 equips macrophages for efficient iron recycling.” Exp Hematol 36: 929-937, 2008.

Zhang A-S, Canonne-Hergaux F, Gruenheid S, Gros P, Ponka P.  “The use of Nramp-2-transfected Chinese hamster ovary cells and reticulocytes from mk/mk mice to study iron transport mechanisms.” Exp Hematol 36: 1227-1235, 2008.

Simunek T, Sterba M, Popelova O, Kaiserova H, Adamcova M, Hroch M, Ponka P, Gersl V.  “Anthracycline toxicity to cardiomyocytes or cancer cells is differently affected by iron chelation with salicylaldehyde isonicotinoyl hydrazone.”  Br J Pharmacol. 155: 138-148, 2008.

Whitnall M. Suryo Rahmanto Y, Sutak R, Xu X, Becker EM, Mikhael M, Ponka P*, Richardson DR.  “The MCK mouse heart model of Friedreich’s Ataxia: Marked alterations in iron-regulated proteins and iron chelation limits cardiac hypertrophy.” Proc Natl Acad Sci USA 105: 9757-9762, 2008. *Corresponding author.

Rathore KI, Kerr BJ, Redensek A, López-Vales R, Jeong SY, Ponka P, David S. “Ceruloplasmin protects injured spinal cord from iron-mediated oxidative damage.” J Neurosci. 28: 12736-12747, 2008.

Jeong SY, Rathore KI, Ponka P, Arosio P, David S. “Alteration in Iron Homeostasis Contributes to Disease Progression in a Mouse Model of Amyotrophic Lateral Sclerosis.” J Neurosci (in press).

M. Kodiha, C.M. Brown, U. Stochaj (2008). Analysis of signaling events by combining high throughput screening technology with computer based image analysis. Science Signaling 1:p12.

 


Abstracts:

Robert R., Carlile G.W.*, Liao J., Balghi H., Lesimple P., Liu N., Kus B., Rotin D., Thomas D.Y. and Hanrahan J.W. Correction of ∆F508-CFTR trafficking defect by the bioavailable compound JMCG811 (2008). Pediatric Pulmonology, supplement 31, NACFC, Orlando, USA, October 23-25.

Anjos S.M., Robert R., Carlile G.W., Hanrahan J.W. & Thomas D.Y. Poly ADP-Ribose Polymerase-1 inhibitors correct DF508CFTR trafficking (2008). Pediatric Pulmonology, supplement 31, NACFC, Orlando, USA, October 23-25.

LeSimple P., Robert R., Liao J., Gruenert D.C. & Hanrahan J.W. Wild-type CFTR enhances the barrier function of airway epithelial cell monolayers (2008). Pediatric Pulmonology, supplement 31, NACFC, Orlando, USA, October 23-25.

Shan J., Liao J., Robert R. & Hanrahan J.W. Bicarbonate and fluid secretion by Calu-3 airway epithelial cells (2008). Pediatric Pulmonology, supplement 31, NACFC, Orlando, USA, October 23-25.

Sampson H., Carlile G.W., Robert R., Hanrahan J.W. & Thomas D.Y. The use of differential scanning fluorimetry to identify NBD1-interacting F508del-CFTR correctors (2008). Pediatric Pulmonology, supplement 31, NACFC, Orlando, USA, October 23-25.

Bates I., Luo Y., Pavel C., Evagelidis A., Robert R. & Hanrahan J.W. Membrane insertion and PKC-induced clustering of CFTR imaged using pH sensitive GFP (2008). Pediatric Pulmonology, supplement 31, NACFC, Orlando, USA, October 23-25.

Zhang D., Balghi H., Teske K., Liao J., Carlile G.W., Robert R., Luo Y., Hanrahan J.W. & Thomas D.Y. Nanomolar concentrations of ouabain induce CFTR expression and correct the trafficking of DF508-CFTR channels in human epithelial cells (2008). Pediatric Pulmonology, supplement 31, NACFC, Orlando, USA, October 23-25.

Petrof B., Divangahi M., Balghi H., Danialou G., Robert R., Haston C., Hanrahan J.W. & Radzioch D. Diaphragm skeletal muscle lacking CFTR shows a hyperinflammatory phenotype with exaggerated atrophy and force loss during Pseudomonas infection (2008). Pediatric Pulmonology, supplement 31, NACFC, Orlando, USA, October 23-25.

P. Bański, M. Kodiha, N. Crampton, D. Mahboubi, U. Stochaj (2008) Hsc70 accumulates in nucleoli of mammalian cells following recovery from heat shock. 1st Annual GRASP Symposium, Montreal, November 2008.

M. Kodiha, P. Bański, D. Ho-Wo-Cheong, H. Mahboubi, L. Johns, N. Crampton, U. Stochaj (2008) Dissecting the mechanisms of stress-induced nuclear accumulation of nuclear transport factors with new quantitative imaging techniques. ASCB-meeting, San Francisco, December 2008.

M. Kodiha, P. Bański, D. Ho-Wo-Cheong, R. Umar, U. Stochaj (2008) A novel quantitative immunofluorescence approach to study the subcellular distribution of proteins. 1st Annual GRASP Symposium, Montreal, November 2008.