|McIntyre Medical Building
3655 Prom. Sir-William-Osler
Montreal, QC, H3G 1Y6
Email: paul [dot] clarke [at] mcgill [dot] ca
After a childhood in Africa, I was educated in England (MA Cambridge, PhD Kings College London) and received postdoctoral training at NIMH (Bethesda, USA) and UBC.
Addiction research Why are drugs such as nicotine, amphetamine and cocaine so addictive? Clearly, brain dopamine is important here, but does it play a specialized role in reward, or a more general role in helping the organism organize its behaviour? Among addictive drugs, nicotine is especially puzzling; we believe standard animal models do not fully capture the effects of nicotine that motivate tobacco smoking, and we are trying new approaches.
Rat ultrasonic vocalizations Rats seem silent to us, but they are in fact quite vocal - but at frequencies beyond our hearing range. The ultrasonic (20-80 kHz) vocalizations made by adult rats are remarkably varied and may convey complex information. These calls may yet be of use in animal models of human disorders such as drug addiction, depression and anxiety.