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Roger Prichard - Publications

Urdaneta L, Beech R, Dent J and Prichard R (2014) A dyf-7 haplotype causes sensory neuron defects and is associated with macrocyclic lactone resistance worldwide in the nematode parasite Haemonchus contortus. International Journal For Parasitology In Press:

Nana-Djeunga HC, Bourguinat C, Pion SD, et al. (2014) Reproductive status of Onchocerca volvulus after ivermectin treatment in an ivermectin-naive and a frequently treated population from Cameroon. PLoS Neglected Tropical Diseases 8: e2824.

Turner HC, Walker M, Churcher TS, et al. (2014) Reaching the London Declaration on Neglected Tropical Diseases Goals for Onchocerciasis: An Economic Evaluation of Increasing the Frequency of Ivermectin Treatment in Africa. Clinical Infectious Diseases

van Westerloo DJ, Landman GW, Prichard R, Lespine A and Visser LG (2014) Persistent coma in Strongyloides hyperinfection syndrome associated with persistently increased ivermectin levels. Clin Infect Dis 58: 143-4.

Ashraf S and Prichard RK (2014) Haemonchus contortus microtubules are cold resistant. Molecular And Biochemical Parasitology 193: 20-2.

Kotze A, Hunt P, Skuce P, et al. (2014) Recent advances in candidate-gene and whole-genome approaches to the discovery of anthelmintic resistance markers and the description of drug / receptor interactions. International Journal for Parasitology Drugs and Drug Resistance

Bygarski EE, Prichard RK and Ardelli BF (2014) Resistance to the macrocyclic lactone moxidectin is mediated in part by membrane transporter P-glycoproteins: Implications for control of drug resistant parasitic nematodes. International Journal for Parasitology : Drugs and Drug Resistance 4: 143-51.

Barrere V, Beech RN, Charvet CL and Prichard RK (2014) Novel assay for the detection and monitoring of levamisole resistance in Haemonchus contortus. International Journal for Parasitology 44: 235-41.

Diawara A, Schwenkenbecher JM, Kaplan RM and Prichard RK (2013) Molecular and biological diagnostic tests for monitoring benzimidazole resistance in human soil-transmitted helminths. American Journal of Tropical Medicine and Hygine 88: 1052-61.

Diawara A, Halpenny CM, Churcher TS, et al. (2013) Association between response to albendazole treatment and beta-tubulin genotype frequencies in soil-transmitted helminths. PLoS Neglected Tropical Diseases 7: e2247.

Turner HC, Churcher TS, Walker M, Osei-Atweneboana MY, Prichard RK and Basanez MG (2013) Uncertainty surrounding projections of the long-term impact of ivermectin treatment on human onchocerciasis. PLoS Negl Trop Dis 7: e2169.

Pion SD, Nana-Djeunga HC, Kamgno J, et al. (2013) Dynamics of Onchocerca volvulus microfilarial densities after ivermectin treatment in an ivermectin-naive and a multiply treated population from Cameroon. PLoS Negl Trop Dis 7: e2084.

Hansen TV, Thamsborg SM, Olsen A, Prichard RK and Nejsum P (2013) Genetic variations in the beta-tubulin gene and the internal transcribed spacer 2 region of Trichuris species from man and baboons. Parasit Vectors 6: 236.

Barrere V, Falzon LC, Shakya KP, Menzies PI, Peregrine AS and Prichard RK (2013) Assessment of benzimidazole resistance in Haemonchus contortus in sheep flocks in Ontario, Canada: comparison of detection methods for drug resistance. Veterinary Parasitology 198: 159-65.

Ardelli BF and Prichard RK (2013) Inhibition of P-glycoprotein enhances sensitivity of Caenorhabditis elegans to ivermectin. Veterinary Parasitology 191: 264-75.

Barrere V, Keller K, von Samson-Himmelstjerna G and Prichard RK (2013) Efficiency of a genetic test to detect benzimidazole resistant Haemonchus contortus nematodes in sheep farms in Quebec, Canada. Parasitology International 62: 464-70.

Menez C, Sutra JF, Prichard R and Lespine A (2012) Relative neurotoxicity of ivermectin and moxidectin in Mdr1ab (-/-) mice and effects on mammalian GABA(A) channel activity. PLoS Negl Trop Dis 6: e1883.

McCarthy JS, Lustigman S, Yang GJ, et al. (2012) A research agenda for helminth diseases of humans: diagnostics for control and elimination programmes. PLoS Negl Trop Dis 6: e1601.

Lustigman S, Prichard RK, Gazzinelli A, et al. (2012) A research agenda for helminth diseases of humans: the problem of helminthiases. PLoS Negl Trop Dis 6: e1582.

Prichard RK, Basanez MG, Boatin BA, et al. (2012) A research agenda for helminth diseases of humans: intervention for control and elimination. PLoS Negl Trop Dis 6: e1549.

Basanez MG, McCarthy JS, French MD, et al. (2012) A research agenda for helminth diseases of humans: modelling for control and elimination. PLoS Negl Trop Dis 6: e1548.

Boatin BA, Basanez MG, Prichard RK, et al. (2012) A research agenda for helminth diseases of humans: towards control and elimination. PLoS Negl Trop Dis 6: e1547.

Vercruysse J, Levecke B and Prichard R (2012) Human soil-transmitted helminths: implications of mass drug administration. Curr Opin Infect Dis 25: 703-8.

Yan R, Urdaneta-Marquez L, Keller K, James CE, Davey MW and Prichard RK (2012) The role of several ABC transporter genes in ivermectin resistance in Caenorhabditis elegans. Vet Parasitol 190: 519-29.

Barrere V, Alvarez L, Suarez G, et al. (2012) Relationship between increased albendazole systemic exposure and changes in single nucleotide polymorphisms on the beta-tubulin isotype 1 encoding gene in Haemonchus contortus. Vet Parasitol 186: 344-9.

Nana-Djeunga H, Bourguinat C, Pion SD, et al. (2012) Single nucleotide polymorphisms in beta-tubulin selected in Onchocerca volvulus following repeated ivermectin treatment: possible indication of resistance selection. Mol Biochem Parasitol 185: 10-8.

Prichard R, Menez C and Lespine A (2012) Moxidectin and the avermectins: Consanguinity but not identity. Int J Parasitol Drugs Drug Resist 2: 134-53.

Osei-Atweneboana MY, Boakye DA, Awadzi K, Gyapong JO and Prichard RK (2012) Genotypic analysis of beta-tubulin in Onchocerca volvulus from communities and individuals showing poor parasitological response to ivermectin treatment. Int J Parasitol Drugs Drug Resist 2: 20-8.

Lespine A, Menez C, Bourguinat C and Prichard RK (2012) P-glycoproteins and other multidrug resistance transporters in the pharmacology of anthelmintics: Prospects for reversing transport-dependent anthelmintic resistance. Int J Parasitol Drugs Drug Resist 2: 58-75.

Krecek RC, Penzhorn BL, de Waal DT, Peter RJ, Prichard R and Sumption D (2011) Origin and history to date of the World Association for the Advancement of Veterinary Parasitology (WAAVP) African Foundation. J S Afr Vet Assoc 82: 6-7.

Bourguinat C, Bhan A, Peregrine A, Geary T and Prichard R (2011) Macrocyclic lactone resistance in Dirofilaria immitis: Letter to the Editor. Vet Parasitol 182: 380-381.

Osei-Atweneboana MY, Awadzi K, Attah SK, Boakye DA, Gyapong JO and Prichard RK (2011) Phenotypic evidence of emerging ivermectin resistance in Onchocerca volvulus. PLoS Negl Trop Dis 5: e998.

Osei-Atweneboana MY, Awadzi K, Attah SK, Boakye DA, Gyapong JO and Prichard RK (2011) Phenotypic evidence of emerging ivermectin resistance in Onchocerca volvulus. PLoS Negl Trop Dis 5: e998.

Geary TG, Bourguinat C and Prichard RK (2011) Evidence for macrocyclic lactone anthelmintic resistance in Dirofilaria immitis. Top Companion Anim Med 26: 186-92.

Beech RN, Skuce P, Bartley DJ, Martin RJ, Prichard RK and Gilleard JS (2011) Anthelmintic resistance: markers for resistance, or susceptibility? Parasitology 138: 160-74.

Bourguinat C, Keller K, Bhan A, Peregrine A, Geary T and Prichard R (2011) Macrocyclic lactone resistance in Dirofilaria immitis. Vet Parasitol 181: 388-92.

Bourguinat C, Keller K, Blagburn B, Schenker R, Geary TG and Prichard RK (2011) Correlation between loss of efficacy of macrocyclic lactone heartworm anthelmintics and P-glycoprotein genotype. Vet Parasitol 176: 374-81.

Bourguinat C, Keller K, Prichard RK and Geary TG (2011) Genetic polymorphism in Dirofilaria immitis. Vet Parasitol 176: 368-73.

Vercruysse J, Albonico M, Behnke JM, et al. (2011) Is anthelmintic resistance a concern for the control of human soil-transmitted helminths? Int J Parasitol Drugs Drug Resist 1: 14-27.

Rao VT, Forrester SG, Keller K and Prichard RK (2011) Localisation of serotonin and dopamine in Haemonchus contortus. Int J Parasitol 41: 249-54.

Bourguinat C, Kamgno J, Boussinesq M, Mackenzie CD, Prichard RK and Geary TG (2010) Analysis of the mdr-1 gene in patients co-infected with Onchocerca volvulus and Loa loa who experienced a post-ivermectin serious adverse event. Am J Trop Med Hyg 83: 28-32.

Rao VT, Accardi MV, Siddiqui SZ, Beech RN, Prichard RK and Forrester SG (2010) Characterization of a novel tyramine-gated chloride channel from Haemonchus contortus. Molecular and biochemical parasitology 173: 64-8.

Geary TG, Woo K, McCarthy JS, et al. (2010) Unresolved issues in anthelmintic pharmacology for helminthiases of humans. Int J Parasitol 40: 1-13.

Diawara A, Drake LJ, Suswillo RR, et al. (2009) Assays to detect beta-tubulin codon 200 polymorphism in Trichuris trichiura and Ascaris lumbricoides. PLoS Negl Trop Dis 3: e397.

Taylor MJ, Awadzi K, Basanez MG, et al. (2009) Onchocerciasis Control: Vision for the Future from a Ghanian perspective. Parasit Vectors 2: 7.

Churcher TS, Pion SD, Osei-Atweneboana MY, et al. (2009) Identifying sub-optimal responses to ivermectin in the treatment of River Blindness. Proc Natl Acad Sci U S A 106: 16716-21.

Ardelli BF, Stitt LE, Tompkins JB and Prichard RK (2009) A comparison of the effects of ivermectin and moxidectin on the nematode Caenorhabditis elegans. Vet Parasitol 165: 96-108.

Rao VT, Siddiqui SZ, Prichard RK and Forrester SG (2009) A dopamine-gated ion channel (HcGGR3*) from Haemonchus contortus is expressed in the cervical papillae and is associated with macrocyclic lactone resistance. Mol Biochem Parasitol 166: 54-61.

Churcher TS, Schwab AE, Prichard RK and Basanez MG (2008) An analysis of genetic diversity and inbreeding in Wuchereria bancrofti: implications for the spread and detection of drug resistance. PLoS Negl Trop Dis 2: e211.

de Lourdes Mottier M and Prichard RK (2008) Genetic analysis of a relationship between macrocyclic lactone and benzimidazole anthelmintic selection on Haemonchus contortus. Pharmacogenet Genomics 18: 129-40.

Prichard RK and Geary TG (2008) Drug discovery: fresh hope to can the worms. Nature 452: 157-8.

Blackhall WJ, Prichard RK and Beech RN (2008) P-glycoprotein selection in strains of Haemonchus contortus resistant to benzimidazoles. Vet Parasitol 152: 101-7.

Lespine A, Alvinerie M, Vercruysse J, Prichard RK and Geldhof P (2008) ABC transporter modulation: a strategy to enhance the activity of macrocyclic lactone anthelmintics. Trends Parasitol 24: 293-8.

Bourguinat C, Ardelli BF, Pion SD, et al. (2008) P-glycoprotein-like protein, a possible genetic marker for ivermectin resistance selection in Onchocerca volvulus. Mol Biochem Parasitol 158: 101-11.