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John Dalton - Publications

Skinner-Adams, TS, Peatey, CL, Anderson, K, Trenholme, KR, Krige, D, Brown, CL, Stack, C, Nsangou, DM, Mathews, RT, Thivierge, K, Dalton, JP and Gardiner, DL (2012)
The aminopeptidase inhibitor CHR-2863 is an orally bioavailable inhibitor of murine malaria. Antimicrobial agents and chemotherapy
Poreba, M, McGowan, S, Skinner-Adams, TS, Trenholme, KR, Gardiner, DL, Whisstock, JC, To, J, Salvesen, GS, Dalton, JP and Drag, M (2012)
Fingerprinting the substrate specificity of M1 and M17 aminopeptidases of human malaria, Plasmodium falciparum. PloS one 7 e31938.
Dalton, JP, Demanga, CG, Reiling, SJ, Wunderlich, J, Eng, JW and Rohrbach, P (2012)
Large-scale growth of the Plasmodium falciparum malaria parasite in a wave bioreactor. International journal for parasitology 42 215-20.
Jones, PM, Robinson, MW, Dalton, JP and George, AM (2011)
The Plasmodium falciparum malaria M1 alanyl aminopeptidase (PfA-M1): insights of catalytic mechanism and function from MD simulations. PloS one 6 e28589.
McVeigh, P, Maule, AG, Dalton, JP and Robinson, MW (2012)
Fasciola hepatica virulence-associated cysteine peptidases: a systems biology perspective. Microbes and infection / Institut Pasteur 14 301-10.
Stack, C, Dalton, JP and Robinson, MW (2011)
The phylogeny, structure and function of trematode cysteine proteases, with particular emphasis on the Fasciola hepatica cathepsin L family. Advances in experimental medicine and biology 712 116-35.
Robinson, MW, Donnelly, S, Hutchinson, AT, To, J, Taylor, NL, Norton, RS, Perugini, MA and Dalton, JP (2011)
A family of helminth molecules that modulate innate cell responses via molecular mimicry of host antimicrobial peptides. PLoS pathogens 7 e1002042.
Robinson, MW, Corvo, I, Jones, PM, George, AM, Padula, MP, To, J, Cancela, M, Rinaldi, G, Tort, JF, Roche, L and Dalton, JP (2011)
Collagenolytic activities of the major secreted cathepsin L peptidases involved in the virulence of the helminth pathogen, Fasciola hepatica. PLoS neglected tropical diseases 5 e1012.
Trenholme, K. R., Brown, C. L., Skinner-Adams, T. S., Stack, C., Lowther, J., To, J., Robinson, M. W., Donnelly, S. M., Dalton, J. P., Gardiner, D. L. (2010)
Aminopeptidases of malaria parasites: new targets for chemotherapy. Infectious disorders drug targets 10 217-225.
Sripa, J., Laha, T., To, J., Brindley, P. J., Sripa, B., Kaewkes, S., Dalton, J. P., Robinson, M. W. (2010)
Secreted cysteine proteases of the carcinogenic liver fluke, Opisthorchis viverrini: regulation of cathepsin F activation by autocatalysis and trans-processing by cathepsin B. Cellular microbiology 12 781-795.
Skinner-Adams, T. S., Stack, C. M., Trenholme, K. R., Brown, C. L., Grembecka, J., Lowther, J., Mucha, A., Drag, M., Kafarski, P., McGowan, S., Whisstock, J. C., Gardiner, D. L., Dalton, J. P. (2010)
Plasmodium falciparum neutral aminopeptidases: new targets for anti-malarials. Trends in biochemical sciences 35 53-61.
Robinson, M. W., Hutchinson, A. T., Donnelly, S., Dalton, J. P. (2010)
Worm secretory molecules are causing alarm. Trends in Parasitology 26 371-372.
Robinson, M. W., Hutchinson, A. T., Dalton, J. P., Donnelly, S. (2010)
Peroxiredoxin: a central player in immune modulation. Parasite immunology 32 305-313.
Mucha, A., Drag, M., Dalton, J. P., Kafarski, P. (2010)
Metallo-aminopeptidase inhibitors. Biochimie 92 1509-1529.
Moran, B. W., Anderson, F. P., Ruth, D. M., Fagain, C. O., Dalton, J. P., Kenny, P. T. (2010)
Fluorobenzoyl dipeptidyl derivatives as inhibitors of the Fasciola hepatica cysteine protease cathepsin L1. Journal of enzyme inhibition and medicinal chemistry 25 1-12.
Mendes, R. E., Perez-Ecija, R. A., Zafra, R., Buffoni, L., Martinez-Moreno, A., Dalton, J. P., Mulcahy, G., Perez, J. (2010)
Evaluation of hepatic changes and local and systemic immune responses in goats immunized with recombinant Peroxiredoxin (Prx) and challenged with Fasciola hepatica. Vaccine 28 2832-2840.
McGowan, S., Oellig, C. A., Birru, W. A., Caradoc-Davies, T. T., Stack, C. M., Lowther, J., Skinner-Adams, T., Mucha, A., Kafarski, P., Grembecka, J., Trenholme, K. R., Buckle, A. M., Gardiner, D. L., Dalton, J. P., Whisstock, J. C. (2010)
Structure of the Plasmodium falciparum M17 aminopeptidase and significance for the design of drugs targeting the neutral exopeptidases. Proceedings of the National Academy of Sciences of the United States of America 107 2449-2454.
Golden, O., Flynn, R. J., Read, C., Sekiya, M., Donnelly, S. M., Stack, C., Dalton, J. P., Mulcahy, G. (2010)
Protection of cattle against a natural infection of Fasciola hepatica by vaccination with recombinant cathepsin L1 (rFhCL1). Vaccine 28 5551-5557.
El Ridi, R., Tallima, H., Mahana, N., Dalton, J. P. (2010)
Innate immunogenicity and in vitro protective potential of Schistosoma mansoni lung schistosomula excretory--secretory candidate vaccine antigens. Microbes and infection / Institut Pasteur 12 700-709.
Donnelly, S., O'Neill, S. M., Stack, C. M., Robinson, M. W., Turnbull, L., Whitchurch, C., Dalton, J. P. (2010)
Helminth cysteine proteases inhibit TRIF-dependent activation of macrophages via degradation of TLR3. The Journal of biological chemistry 285 3383-3392.
Robinson, M. W., Menon, R., Donnelly, S. M., Dalton, J. P., Ranganathan, S. (2009)
An integrated transcriptomics and proteomics analysis of the secretome of the helminth pathogen Fasciola hepatica: proteins associated with invasion and infection of the mammalian host. Molecular & cellular proteomics : MCP 8 1891-1907.
Robinson, M. W., Dalton, J. P. (2009)
Zoonotic helminth infections with particular emphasis on fasciolosis and other trematodiases. Philosophical transactions of the Royal Society of London. Series B, Biological sciences 364 2763-2776.
Rinaldi, G., Morales, M. E., Alrefaei, Y. N., Cancela, M., Castillo, E., Dalton, J. P., Tort, J. F., Brindley, P. J. (2009)
RNA interference targeting leucine aminopeptidase blocks hatching of Schistosoma mansoni eggs. Molecular and Biochemical Parasitology 167 118-126.
Pinlaor, P., Kaewpitoon, N., Laha, T., Sripa, B., Kaewkes, S., Morales, M. E., Mann, V. H., Parriott, S. K., Suttiprapa, S., Robinson, M. W., To, J., Dalton, J. P., Loukas, A., Brindley, P. J. (2009)
Cathepsin F cysteine protease of the human liver fluke, Opisthorchis viverrini. PLoS Neglected Tropical Diseases 3 e398.
Miller, C. M., Smith, N. C., Ikin, R. J., Boulter, N. R., Dalton, J. P., Donnelly, S. (2009)
Immunological interactions between 2 common pathogens, Th1-inducing protozoan Toxoplasma gondii and the Th2-inducing helminth Fasciola hepatica. PLoS One 4 e5692.
McGowan, S., Porter, C. J., Lowther, J., Stack, C. M., Golding, S. J., Skinner-Adams, T. S., Trenholme, K. R., Teuscher, F., Donnelly, S. M., Grembecka, J., Mucha, A., Kafarski, P., Degori, R., Buckle, A. M., Gardiner, D. L., Whisstock, J. C., Dalton, J. P. (2009)
Structural basis for the inhibition of the essential Plasmodium falciparum M1 neutral aminopeptidase. Proceedings of the National Academy of Sciences of the United States of America 106 2537-2542.
Maric, S., Donnelly, S. M., Robinson, M. W., Skinner-Adams, T., Trenholme, K. R., Gardiner, D. L., Dalton, J. P., Stack, C. M., Lowther, J. (2009)
The M17 leucine aminopeptidase of the malaria parasite Plasmodium falciparum: importance of active site metal ions in the binding of substrates and inhibitors. Biochemistry 48 5435-5439.
Lowther, J., Robinson, M. W., Donnelly, S. M., Xu, W., Stack, C. M., Matthews, J. M., Dalton, J. P. (2009)
The importance of pH in regulating the function of the Fasciola hepatica cathepsin L1 cysteine protease. PLoS Neglected Tropical Diseases 3 e369.
Kasny, M., Mikes, L., Hampl, V., Dvorak, J., Caffrey, C. R., Dalton, J. P., Horak, P. (2009)
Chapter 4. Peptidases of trematodes. Advances in Parasitology 69 205-297.
Goh, F., Irvine, K. M., Lovelace, E., Donnelly, S., Jones, M. K., Brion, K., Hume, D. A., Kotze, A. C., Dalton, J. P., Ingham, A., Sweet, M. J. (2009)
Selective induction of the Notch ligand Jagged-1 in macrophages by soluble egg antigen from Schistosoma mansoni involves ERK signalling. Immunology 127 326-337.
Gardiner, D. L., Skinner-Adams, T. S., Brown, C. L., Andrews, K. T., Stack, C. M., McCarthy, J. S., Dalton, J. P., Trenholme, K. R. (2009)
Plasmodium falciparum: new molecular targets with potential for antimalarial drug development. Expert review of anti-infective therapy 7 1087-1098.
Dalton, J. P., Brindley, P. J., Donnelly, S., Robinson, M. W. (2009)
The enigmatic asparaginyl endopeptidase of helminth parasites. Trends in Parasitology 25 59-61.
Stack, C. M., Caffrey, C. R., Donnelly, S. M., Seshaadri, A., Lowther, J., Tort, J. F., Collins, P. R., Robinson, M. W., Xu, W., McKerrow, J. H., Craik, C. S., Geiger, S. R., Marion, R., Brinen, L. S., Dalton, J. P. (2008)
Structural and functional relationships in the virulence-associated cathepsin L proteases of the parasitic liver fluke, Fasciola hepatica. The Journal of biological chemistry 283 9896-9908.
Robinson, M. W., Tort, J. F., Lowther, J., Donnelly, S. M., Wong, E., Xu, W., Stack, C. M., Padula, M., Herbert, B., Dalton, J. P. (2008)
Proteomics and phylogenetic analysis of the cathepsin L protease family of the helminth pathogen Fasciola hepatica: expansion of a repertoire of virulence-associated factors. Molecular & cellular proteomics : MCP 7 1111-1123.
Robinson, M. W., Dalton, J. P., Donnelly, S. (2008)
Helminth pathogen cathepsin proteases: it's a family affair. Trends in biochemical sciences 33 601-608.
McGonigle, L., Mousley, A., Marks, N. J., Brennan, G. P., Dalton, J. P., Spithill, T. W., Day, T. A., Maule, A. G. (2008)
The silencing of cysteine proteases in Fasciola hepatica newly excysted juveniles using RNA interference reduces gut penetration. International Journal for Parasitology 38 149-155.
Donnelly, S., Stack, C. M., O'Neill, S. M., Sayed, A. A., Williams, D. L., Dalton, J. P. (2008)
Helminth 2-Cys peroxiredoxin drives Th2 responses through a mechanism involving alternatively activated macrophages. The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 22 4022-4032.
Teuscher, F., Lowther, J., Skinner-Adams, T. S., Spielmann, T., Dixon, M. W., Stack, C. M., Donnelly, S., Mucha, A., Kafarski, P., Vassiliou, S., Gardiner, D. L., Dalton, J. P., Trenholme, K. R. (2007)
The M18 aspartyl aminopeptidase of the human malaria parasite Plasmodium falciparum. The Journal of biological chemistry 282 30817-30826.
Stack, C. M., Lowther, J., Cunningham, E., Donnelly, S., Gardiner, D. L., Trenholme, K. R., Skinner-Adams, T. S., Teuscher, F., Grembecka, J., Mucha, A., Kafarski, P., Lua, L., Bell, A., Dalton, J. P. (2007)
Characterization of the Plasmodium falciparum M17 leucyl aminopeptidase. A protease involved in amino acid regulation with potential for antimalarial drug development. The Journal of biological chemistry 282 2069-2080.
Stack, C. M., Donnelly, S., Lowther, J., Xu, W., Collins, P. R., Brinen, L. S., Dalton, J. P. (2007)
The major secreted cathepsin L1 protease of the liver fluke, Fasciola hepatica: a Leu-12 to Pro-12 replacement in the nonconserved C-terminal region of the prosegment prevents complete enzyme autoactivation and allows definition of the molecular events in prosegment removal. The Journal of biological chemistry 282 16532-16543.
Skinner-Adams, T. S., Lowther, J., Teuscher, F., Stack, C. M., Grembecka, J., Mucha, A., Kafarski, P., Trenholme, K. R., Dalton, J. P., Gardiner, D. L. (2007)
Identification of phosphinate dipeptide analog inhibitors directed against the Plasmodium falciparum M17 leucine aminopeptidase as lead antimalarial compounds. Journal of medicinal chemistry 50 6024-6031.
Parkinson, M., O'Neill, S. M., Dalton, J. P. (2007)
Endemic human fasciolosis in the Bolivian Altiplano. Epidemiology and infection 135 669-674.
Parkinson, M., O'Neill S, M., Dalton, J. P. (2007)
Controlling fasciolosis in the Bolivian Altiplano. Trends in Parasitology 23 238-239.
Kasny, M., Mikes, L., Dalton, J. P., Mountford, A. P., Horak, P. (2007)
Comparison of cysteine peptidase activities in Trichobilharzia regenti and Schistosoma mansoni cercariae. Parasitology 134 1599-1609.
Flynn, R. J., Irwin, J. A., Olivier, M., Sekiya, M., Dalton, J. P., Mulcahy, G. (2007)
Alternative activation of ruminant macrophages by Fasciola hepatica. Veterinary immunology and immunopathology 120 31-40.
Sekiya, M., Mulcahy, G., Irwin, J. A., Stack, C. M., Donnelly, S. M., Xu, W., Collins, P., Dalton, J. P. (2006)
Biochemical characterisation of the recombinant peroxiredoxin (FhePrx) of the liver fluke, Fasciola hepatica. FEBS letters 580 5016-5022.
McManus, D. P., Dalton, J. P. (2006)
Vaccines against the zoonotic trematodes Schistosoma japonicum, Fasciola hepatica and Fasciola gigantica. Parasitology 133 Suppl S43-61.
Gardiner, D. L., Trenholme, K. R., Skinner-Adams, T. S., Stack, C. M., Dalton, J. P. (2006)
Overexpression of leucyl aminopeptidase in Plasmodium falciparum parasites. Target for the antimalarial activity of bestatin. The Journal of biological chemistry 281 1741-1745.
Donnelly, S., Dalton, J. P., Loukas, A. (2006)
Proteases in helminth- and allergen- induced inflammatory responses. Chemical immunology and allergy 90 45-64.
Stack, C. M., Dalton, J. P., Cunneen, M., Donnelly, S. (2005)
De-glycosylation of Pichia pastoris-produced Schistosoma mansoni cathepsin B eliminates non-specific reactivity with IgG in normal human serum. Journal of immunological methods 304 151-157.
Khaznadji, E., Collins, P., Dalton, J. P., Bigot, Y., Moire, N. (2005)
A new multi-domain member of the cystatin superfamily expressed by Fasciola hepatica. International Journal for Parasitology 35 1115-1125.
Donnelly, S., O'Neill, S. M., Sekiya, M., Mulcahy, G., Dalton, J. P. (2005)
Thioredoxin peroxidase secreted by Fasciola hepatica induces the alternative activation of macrophages. Infection and immunity 73 166-173.
Mulcahy, G., O'Neill, S., Donnelly, S., Dalton, J. P. (2004)
Helminths at mucosal barriers--interaction with the immune system. Advanced drug delivery reviews 56 853-868.
McCarthy, E., Stack, C., Donnelly, S. M., Doyle, S., Mann, V. H., Brindley, P. J., Stewart, M., Day, T. A., Maule, A. G., Dalton, J. P. (2004)
Leucine aminopeptidase of the human blood flukes, Schistosoma mansoni and Schistosoma japonicum. International Journal for Parasitology 34 703-714.
Irwin, J. A., Morrissey, P. E., Ryan, J. P., Walshe, A., O'Neill, S. M., Carrington, S. D., Matthews, E., Fitzpatrick, E., Mulcahy, G., Corfield, A. P., Dalton, J. P. (2004)
Glycosidase activity in the excretory-secretory products of the liver fluke, Fasciola hepatica. Parasitology 129 465-472.
Collins, P. R., Stack, C. M., O'Neill, S. M., Doyle, S., Ryan, T., Brennan, G. P., Mousley, A., Stewart, M., Maule, A. G., Dalton, J. P., Donnelly, S. (2004)
Cathepsin L1, the major protease involved in liver fluke (Fasciola hepatica) virulence: propetide cleavage sites and autoactivation of the zymogen secreted from gastrodermal cells. The Journal of biological chemistry 279 17038-17046.