(1) Antigen presentation in the context of MHC-I in cells actively infected by Toxoplasma gondii
Primary astrocytes infected with transgenic T. gondii parasites secreting the model antigen ovalbumin in the vacuole. Blue (DAPI): astrocyte nuclei and parasite nuclear and apicoplast DNA. Green: complexes [MHC-I/OVA epitope] labeled by the specific monoclonal antibody 25-D1.16 (kindly provided by R. Germain).
Note that only infected cells present OVA in the context of MHC-I (Dzierszinski et al., in preparation).
Research at the Institute of Parasitologyfocuses on the interaction between host and parasitic disease organisms with a view to controlling infection by these organisms. Many different perspectives brought by the staff provide a unique opportunity to examine aspects of infection ranging from the cellular mechanisms which govern this process, the immune response of the host, immunosuppression mechanisms used by parasites to assist infection and the epidemiology of parasitic diseases.
There are currently 11 research labs at the Institute of Parasitology.