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Translational Research Activities

Joe Miller Lab: The main areas of research past and present include orthopaedic biomaterials and biomechanics, non-cemented implant fixation, porous materials, tissue response, bone remodeling response to total joint prostheses, drug delivery from implants for fixation enhancement, de-mineralized bone matrix for fixation enhancement, implant retrieval analysis, implant design, implant stiffness material testing (static and fatigue), stability measurements of knee and hip implants, hip simulator testing of bearing materials with emphasis on hard/hard bearings such as cobalt-chrome/cobalt-chrome and ceramic/ceramic and highly cross-linked polyethylene.

JTN Wong Lab: Current research is focused on skeletal regeneration and reconstruction using small animal models of implant infection and failure, fracture mal-union and repair, steroid-induced bone disease and genetic-based models of disorders of skeletal development and bone metabolism. The lab supports the research programs of clinician scientists from Trauma (Harvey, Henderson, Berry), Paediatrics (Ouellet, Saran) and Sports (Martineau) and from Haematology/Oncology (Seguin). Current trainees include one post PhD fellow, five post MD MSc or PhD candidates, two post BSc MSc candidates and five undergraduate students from high school, biotechnology and MDCM programs.

ORL-LDI: Efforts to characterize disc degeneration using gross morphology, current MR imaging, and biochemical techniques have been disappointing. Thus, one of the long term goals of our research activities is to develop an objective, accurate, non-invasive diagnostic tool (Quantitative MRI) in the detection and quantification of matrix biochemical composition and integrity and biomechanical changes in early disc degeneration. The inception of such a diagnostic tool will be a foundation for future work in diagnosing and treating spine pathology. A second area of research is focused on intervertebral disc regeneration using autologous mesenchymal stem cells embedded in a support scaffold.

ORL-RVH: The McGill Orthopaedic Research Laboratory was founded in May 1993. The Laboratory is a multidisciplinary research facility dedicated to basic and applied spinal research, focusing on the functional spinal unit, and the single motion segment of the spine. Fundamental and clinician scientists in the field of biomechanics, biochemistry, morphology, and electrophysiology, combine to form a fully integrated multidisciplinary laboratory. The group intends to provide a comprehensive understanding of spinal disorders that will lead to an improvement of current diagnostic and therapeutic tools of spinal pathology.

Shriners-MCH: Current research activities remain focused on the molecular basis and treatment of heritable disorders of the appendicular and axial skeleton including disorders of bone and mineral metabolism, limb length discrepancies, hip dysplasia and scoliosis. The work includes development of novel nanoparticle-based delivery systems for biological repair, cloning and characterization of components of the vitamin D signaling pathway, correlation of genotype-phenotype in non-lethal osteogenesis imperfect, molecular biochemical analysis of scoliotic intervertebral discs and the development of novel surgical implants and approaches for the correction of hip and limb length discrepancies and spine curvature.