Journal Publications

Grégoire, S., Xiao, L., Nie, J., Zhang, X., Xu, M., Li, J.,Wong, J., Seto, E. and Yang, X.J. (2006) Histone deacetylase 3 interacts with and deacetylates MEF2 transcription factors. Mol. Cell. Biol., in press.

Yang, X.J. and Grégoire, S. (2006) A recurrent phospho-sumoyl switch in transcriptional repression and beyond. Mol. Cell 23, 779-786.

Kim, S., Sprung, R., Chen, Y., Xu, Y., Ball, H., Pei, J., Cheng, T., Kho, Y., Xiao, H., Lin Xiao, L., Grishin, N.V., White, M., Yang, X.J., and Zhao, Y. (2006) Substrate and functional diversity of lysine acetylation revealed by a proteomics survey. Mol. Cell 23, 607-618.

Hernandez, M., Shao, Q., Yang, X.J., Luh, S.P., Kandouz, M., Batist, G., Laird, D.W., and Alaoui-Jamali, M.A. (2006) A histone deacetylation-dependent mechanism for transcriptional repression of the gap junction gene cx43 in prostate cancer cells. Prostate 66:1151-1161.

Grégoire, S., Tremblay, A. M., Xiao, L., Wu, Z., Giguere, V. and Yang, X.J. (2006) Control of MEF2 transcriptional activity by coordinated phosphorylation and sumoylation. J. Biol. Chem. 281, 4423-4433.

Doyon, Y., Cayrou, C., Ullah, M., Landry, A. J., Cote, V., Selleck, W., Lane, W. S., Tan, S., Yang, X. J., and Cote, J. (2006). ING tumor suppressors are critical regulators of chromatin acetylation required for genome expression and perpetuation. Mol. Cell 21, 51-64.

Wang, A.H., Grégoire, S., Zika, E., Xiao, L., Li, C.S., Li, H., Wright, K.L., Ting, J.P., and Yang, X.J. (2005) Identification of the ankyrin-repeat proteins ANKRA and RFXANK as novel partners of class IIa histone deacetylases. J. Biol. Chem. 280, 29117-29127.

Yang, X.J. and Grégoire, S. (2005) Class II histone deacetylases: from sequence to function, regulation and clinical implication. Mol. Cell. Biol. 25, 2873-2884.

Grégoire, S. and Yang, X.J. (2005) Association with class IIa histone deacetylases upregulates the sumoylation of MEF2 transcription factors. Mol. Cell. Biol. 25, 2273-2287.

Yang, X.J. (2004) Multisite protein modification and intramolecular signaling. Oncogene 24, 1653-1662.

Bertos, N.R., Gilquin, B., Chan, M., Yen, T.J., Khochbin, S., and Yang, X.J. (2004) Role of the tetradecapeptide-repeat domain of human histone deacetylase 6 in cytoplasmic retention. J. Biol. Chem. 279, 48246-48254.

Yang, X.J. (2004) Lysine acetylation and the bromodomain: a new partnership for signaling. Bioessays 26, 1076-1087.

Sun, L., Liu, L., Yang, X.J., and Wu, Z. (2004) Akt binds prohibitin 2 and relieves its repression of MyoD and muscle differentiation. J. Cell Sci. 117, 3021-3029.

Liu, F., Dowling, M., Yang, X.J., and Kao, G.D. (2004) Caspase-mediated specific cleavage of human histone deacetylase 4. J. Biol. Chem. 279, 34537-34546.

Yang X.J. (2004) The diverse superfamily of lysine acetyltransferases and their roles in leukemia and other diseases. Nucleic Acids Res. 32, 959-976.

White, J.H., Fernandes, I., Mader, S., and Yang, X.J. (2004) Corepressor recruitment by agonist-bound nuclear receptors. Vitamins & Hormones 68, 123-143.

Zhao, L.Y., Liu, Y., Bertos, N.R., Yang, X.J., and Liao, D. (2003) PCAF is a coactivator for p73-mediated transactivation. Oncogene 22, 8316-29.

Pelletier, N., Champagne, N., Lim, H., and Yang, X.J. (2003) Expression, purification and analysis of the MOZ and MORF histone acetyltransferases. Methods 31, 24-32.

Yang, X.J. and Seto, E. (2003) Collaborative spirit of histone deacetylases in regulating chromatin structure and gene expression. Curr. Opin. Genet. Dev. 13, 143-153.

Chan, J.K., Sun, L., Yang, X.J., Zhu, G., and Wu, Z. (2003) Functional characterization of the amino terminal domain of histone deacetylase HDAC4. J. Biol. Chem., 278, 23515-2352.

Fernandes, I., Bastien, Y., Wai, T., Nygard, K., Lin, R., Cormier, O., Lee, H.S., Eng, F., Betos, N.R., Pelletier, N., Mader, S., Han, V.K.M., Yang, X.J., and White, J.H. (2003) Ligand-dependent nuclear receptor corepressor LCoR functions by histone deacetylase-dependent and -independent mechanisms. Mol. Cell 11, 139-150.

Jin, Y., Zeng, S.X., Dai, M., Yang, X.J., and Lu, H. (2002) MDM2 inhibits PCAF-mediated p53 acetylation. J. Biol. Chem. 277, 30838-30843.

Xu, Q., Yu, L., Liu, L., Cheung, C.F., Li, X., Yee, S.K., Yang, X.J., and Wu, Z. (2002) The p38 MAPK, CaMK and calcineurin-mediated signaling pathways transcriptionally regulate myogenin expression. Mol. Biol. Cell 13, 1940-1952.

Pelletier, N., Champagne, N., Stifani, S., and Yang, X.J. (2002) MOZ and MORF histone acetyltransferases interact with the Runt-domain transcription factor Runx2. Oncogene 21, 2729-2740.

Tong, J.J., Liu, J., Bertos, N.R. and Yang, X.J. (2002) Identification of HDAC10, a novel class II human histone deacetylase containing a leucine-rich domain. Nucleic Acids Res. 30, 1114-1123.

Kruhlak, M.J., Hendzel, M.J., Fischle, W., Bertos, N.R., Hameed, S., Yang, X.J., Verdin, E., and Bazett-Jones, D.P. (2001) Regulation of global acetylation in mitosis through loss of histone acetyltransferases and deacetylases from chromatin. J. Biol. Chem. 276, 38807-38319.

Lai, A., Kennedy, B.K., Barbie, D.A., Bertos, N.R., Yang, X.J., Theberge, M.C., Tsai, S.C., Seto, E., Zhang, Y., Kuzmichev, A., Lane, W. S., Reinberg, D., Harlow, E., and Branton, P.E. (2001) RBP1 recruits the mSIN3 histone deacetylase complex to the 'pocket' of retinoblastoma tumor suppressor family proteins found in limited discrete regions of the nucleus at growth arrest. Mol. Cell. Biol. 21, 2918-2932.

Wang, A.H. and Yang, X.J. (2001) Human histone deacetylase 4 possesses intrinsic nuclear export and import signals. Mol. Cell. Biol. 21, 5992-6005.

Bertos, N.R., Wang, A.H., and Yang, X.J. (2001) Class II histone deacetylases: Structure, function and regulation. Biochem. Cell Biol. 97, 243-252.

Champagne, N., Pelletier, N., and Yang, X.J. (2001) The monocytic leukemia zinc finger protein MOZ is a histone acetyltransferase. Oncogene 20, 404-409.

Saleh, M., Rambaldi, I., Yang, X.J., and Featherstone, M.S. (2000) Cell signalling converts HOX-PBX complexes from repressors to activators of transcription. Mol. Cell. Biol., 20, 8623-8633.

Liu, Y., Colosimo, A.L., Yang, X.J., and Liao, D. (2000) Adenovirus E1B-55-kilodalton oncoprotein inhibits p53 acetylation by PCAF. Mol. Cell. Biol. 20, 5540-5553.

Zhou, X., Richon, V.M., Wang, A.H., Yang, X.J., Rifkind, R.A., and Marks, P.A. (2000) Histone deacetylase 4 associates with extracellular signal-regulated kinases 1 and 2, and its cellular localization is regulated by oncogenic Ras. Proc. Natl. Acad. Sci. USA. 97, 14329-14333.

Wang, A.H., Kruhlak, M.J., Wu, J., Bertos, N.R., Vezmar, M., Posner, B.I., Bazett-Jones, D.P., and Yang, X.J. (2000) Regulation of histone deacetylase 4 by binding of 14-3-3 proteins. Mol. Cell. Biol. 20, 6904-6912.

Wang, A.H., Bertos, N.R., Vezmar, M., Pelletier, N., Crosato, M., Heng, H.H., Th'ng, J., Han, J., and Yang, X.J. (1999) HDAC4, a human histone deacetylase related to yeast HDA1, is a transcriptional corepressor. Mol. Cell. Biol. 19, 7816-7827.

Champagne, N., Bertos, N.R., Pelletier, N., Wang, A. H., Vezmar, M., Yang, Y., Heng, H. H., and Yang, X.J. (1999) Identification of a human histone acetyltransferase related to monocytic leukemia zinc finger protein. J. Biol. Chem. 274, 28528-28536.

Masumi, A., Wang I-M., Lefebvre, B., Yang, X.J., Nakatani, Y., and Ozato, K. (1999) The histone acetylase PCAF is a phorbol-ester inducible coactivator of the IRF family that confers enhanced inteferon responsiveness. Mol. Cell. Biol. 19, 1810-1820.

Krumm A, Madisen L, Yang, X.-J., Goodman R, Nakatani Y, and Groudine, M. (1998) Long-distance transcriptional enhancement by the histone acetyltransferase PCAF. Proc. Natl. Acad. Sci. USA. 95, 13501-13506.

Ogryzko, V.V., Kotani, T., Zhang, X., Schiltz, R.L., Howard, T., Yang, X.-J., Howard, B.H., Qin, J., and Nakatani, Y. (1998) A histone octamer-like structure within the PCAF histone acetylase complex. Cell 94, 35-44.

Blanco, J.C., Minucci, S., Lu, J., Yang, X.-J., Walker, K. K., Chen, H., Evan, R.M., Nakatani, Y., and Ozato, K. (1998) The histone acetylase PCAF is a nuclear receptor coactivator. Genes Dev. 12, 1638-1651.

Cho, H., Orphanides, G., Sun, X., Yang, X.-J., Lees, E., Nakatani, Y., and Reinberg, D. (1998) Isolation of a human RNA polymerase II complex containing factors that modify chromatin structure. Mol. Cell. Biol. 18, 5355-5363.

Smith, E.R., Belote, J.M., Schiltz, R.L., Yang, X.-J., Moore, P.A., Berger, S.L., Nakatani, Y., and Allis, C.D. (1998) Cloning of Drosophila GCN5: conserved features among metazoan GCN5 family members. Nucleic Acids Res. 26, 2948-2954.

Puri, P. L., Sartorelli, V., Yang, X.-J., Hamamori, Y., Ogryzko, V.V., Howrd, B.H., Kedes, L., Wang, J.Y.J., Graessmann, A., Nakatani, Y., and Levrero, M. (1997) Differential roles of p300 and PCAF acetyltransferases in muscle differentiation. Mol. Cell 1, 35-45.

Herrera, J.E., Bergel, M., Yang, X.-J., Nakatani, Y., and Bustin, M. (1997) The histone acetyltransferase activity of human GCN5 and PCAF is stabilized by cofactors. J. Biol. Chem. 272, 27253-27258.

Forsberg, C., Lam, L.T., Yang, X.-J., Nakatani, Y., and Bresnick, E.H. (1997) Human histone acetyltransferase GCN5 exists in a stable macromolecular complex lacking the adapter ADA2. Biochemistry 36, 15918-15924.

Imhof, A., Yang, X.-J., Ogryzko, V.V., Nakatani, Y., Wolffe, A.P., and Ge, H. (1997) Acetylation of general transcription factors by histone acetyltransferases. Curr. Biol. 7, 689-692.

Mizzen, C.A., Yang, X.-J., Kokubo, T., Brownell, J.E., Bannister, A.J. Owen-Hughes, T., Workman, J., Berger, S.L., Kouzarides, T., Nakatani, Y., and Allis, C.D. (1996) The TAFII250 subunit of TFIID has histone acetyltransferase activity. Cell 87, 1261-1270. (The first two authors contributed equally to this work.

Yang, X.-J., Ogryzko, V.V., Nishikawa, J., Howard, B.H., and Nakatani, Y. (1996) A p300/CBP-associated factor that competes with the adenoviral E1A oncoprotein. Nature 382, 319-324.

Kowlessur, D., Yang, X.-J., and Kaufman, S. (1995) Role of the phosphorylation site Ser-16 in the regulation of phenylalanine hydroxylase. Proc. Natl. Acad. Sci. USA. 92, 4743-4747.

Ruvinov, S.B., Yang, X.-J., Parris, K.D., Banik, U., Ahmed, S.A., Miles, E.W., and Sackett, D.L. (1995) The tryptophan synthase alpha2beta2 complex: Alterations in the tunnel probed by the intereaction of Nile Red. J. Biol. Chem. 270, 6357-6379.

Anderson, K.S., Kim, A.Y., Quillen, J.M., Sayers, E., Yang, X.-J., and Miles, E. W. (1995) Kinetic characterization of channel impaired mutants of tryptophan synthase. J. Biol. Chem. 270, 29936-29944.

Yang, X.-J. and Kaufman, S. (1994) High-level expression and deletion mutagenesis of human tryptophan hydroxylase. Proc. Natl. Acad. Sci. USA. 91, 6659-6663.

Schlichting, I., Yang, X.-J., Miles, E.W., Kim, A.Y., and Anderson, K.S. (1994) Structural and kinetic analysis of a channel-impaired mutant of tryptophan synthase. J. Biol. Chem. 269, 26591-26593.

Yang, X.-J. and Miles, E.W. (1993) A novel intersubunit repair mechanism: Critical role of tryptophan synthase beta subunit lysine 167 in ligand-dependent communication in the alpha2beta2 complex. J. Biol. Chem. 268, 22269-22272.

Yang, X.-J. and Miles, E.W. (1992) Threonine 183 and adjacent loop residues in the alpha subunit of tryptophan synthase have critical roles in modulating the activities of the beta subunit in the alpha2beta2 complex. J. Biol. Chem. 267, 7520-7528.

Yang, X.-J., Ruvinov, S.B., and Miles, E.W. (1992) Overexpression and purification of the separate tryptophan synthase alpha and beta subunits from Salmonella typhimurium. Protein Expr. Purif. 3, 347-354.